المؤلفون: Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pierrot, Emannuelle Clappier, Charles G. Mullighan, Ana R. Grosso, J. Andrés Yunes, João T. Barata

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/83e6d6932423405685472917e2af4d77

المؤلفون: Nigel J. Pyne, Susan Pyne

المصدر: Frontiers in Oncology, Vol 8 (2018)

مصطلحات موضوعية: Sphingosine 1-phosphate, breast cancer, Sphingosine 1-phosphate receptor, sphingosine kinase, disease specific survival, cell growth, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2018.00417/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/53b5d11736c44cbe8aea4d2ebc61afe6

المؤلفون: Sun-Hye Shin, Hee-Yeon Kim, Hee-Soo Yoon, Woo-Jae Park, David R. Adams, Nigel J. Pyne, Susan Pyne, Joo-Won Park

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 21, p 8371 (2020)

مصطلحات موضوعية: psoriasis, HWG-35D, sphingosine kinase, sphingosine-1-phosphate, T helper type 17 differentiation, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1422-0067/21/21/8371; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/1f4ba4832f314af19f71c708a3affd1c

المؤلفون: Ling-Wei Hii, Felicia Fei-Lei Chung, Chun Wai Mai, Zong Yang Yee, Hong Hao Chan, Vijay Joseph Raja, Noah Elias Dephoure, Nigel J. Pyne, Susan Pyne, Chee-Onn Leong

المصدر: Cells, Vol 9, Iss 4, p 886 (2020)

مصطلحات موضوعية: cancer stem cells, sphingosine kinase, STAT1, mammospheres, drug synergism, sphingolipids, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/4/886; https://doaj.org/toc/2073-4409

URL الوصول: https://doaj.org/article/9ced413142d1486c84837cbe544b8c98

المؤلفون: Nigel J. Pyne, Susan Pyne, David G. Watson, Robert Bittman, Evgeny Berdyshev, Irina Gorshkova, Francesca Tonelli, Viswanathan Natarajan, Manal Alossaimi

المصدر: Biomolecules, Vol 3, Iss 2, Pp 316-333 (2013)

مصطلحات موضوعية: Sphingosine kinase inhibitors, lyso-phosphatidylinositol, sphingolipids, diadenosine 5′,5′′′-P1,P3-triphosphate, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2218-273X/3/2/316; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/a246bb63785c461c9259b124ddc26ac9

المؤلفون: Nigel J. Pyne, Susan Pyne

المصدر: Molecules, Vol 22, Iss 3, p 344 (2017)

مصطلحات موضوعية: sphingosine 1-phosphate, sphingosine 1-phosphate receptor 1, G-protein coupled receptor megaplex, receptor tyrosine kinase, immune trafficking, neovascularisation, cardiovascular, cancer, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/22/3/344; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/68fca0d74a9445cc96a225cdc78f1f7a

المؤلفون: Susan Pyne, Nigel J Pyne

المصدر: IUPHAR/BPS Guide to Pharmacology CITE. 2023

مصطلحات موضوعية: General Medicine, General Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a22d7b5c7f0549f1ce1f3923b741b7
https://doi.org/10.2218/gtopdb/f776/2023.1

المؤلفون: Federico Torta, Jeongah Oh, Mariam Alsanafi, Susan Pyne, David R. Adams, Ryan D. R. Brown, Nigel J. Pyne

المصدر: Cell Biochemistry and Biophysics

مصطلحات موضوعية: 0301 basic medicine, Ceramide, Fenretinide, Biophysics, Apoptosis, Polubiquitination, Biochemistry, Antioxidants, QH301, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, QD, Inducer, Cytotoxicity, Original Paper, Chemistry, Autophagy, Cell Biology, General Medicine, Dihydroceramide desaturase, Cell biology, De novo synthesis, 030104 developmental biology, 030220 oncology & carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4652a3ab193d4d94d81478e2ec478e3b
https://doi.org/10.1007/s12013-021-00990-1

المؤلفون: Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong

المصدر: Alexander, Stephen Ph; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair; Peters, John A; Veale, Emma L; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Pawson, Adam J; Southan, Christopher; Davies, Jamie A; Boison, Detlev; Burns, Kathryn Elisa; Dessauer, Carmen; Gertsch, Jürg; Helsby, Nuala Ann; Izzo, Angelo A; Koesling, Doris; Ostrom, Rennolds; ... (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British journal of pharmacology, 178(Suppl. 1), S313-S411. Wiley 10.1111/bph.15542 <http://dx.doi.org/10.1111/bph.15542>

مصطلحات موضوعية: Pharmacology, RM, Clinical pharmacology, Databases, Pharmaceutical, Computer science, Receptors, Cytoplasmic and Nuclear, 610 Medicine & health, Ligands, Ion Channels, Receptors, G-Protein-Coupled, law.invention, law, Summary information, Humans, 570 Life sciences, biology, Catalytic receptors, RC

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121ee1cf530f801dfca85582efb2536
https://boris.unibe.ch/161549/1/bph.15542.pdf

المؤلفون: Nigel J. Pyne, Rothwelle J. Tate, Federico Torta, David R. Adams, Jeongah Oh, Susan Pyne, Ryan D. R. Brown, Margaret R. Cunningham, Ben E.P. Veerman

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, translocation, Chromosomal translocation, plasma membrane, Biochemistry, chemistry.chemical_compound, AUC, area under the curve, Mice, Sph, sphingosine, Sphingosine, R-loop, regulatory loop, structural biology, PA, phosphatidic acid, ERK, extracellular signal–regulated protein kinase, PLAs, proximity ligation assays, chemistry.chemical_classification, biology, Chemistry, PS, phosphatidylserine, CTD, C-terminal domain, Cell biology, Amino acid, Phosphotransferases (Alcohol Group Acceptor), Protein Transport, Sphingosine kinase 1, PLD2, phospholipase D2, PM, plasma membrane, MCF-7 Cells, Female, fluorescence, FIPI, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide hydrochloride, Research Article, PMA, phorbol 12-myristate 13-acetate, LBL-1, lipid-binding loop 1, hSK1, human SK1, Breast Neoplasms, SK1, sphingosine kinase 1, RS, RC0254, 03 medical and health sciences, Membrane Microdomains, Animals, Humans, enzyme mechanism, Sphingosine-1-phosphate, NTD, N-terminal domain, Sphingosine-1-phosphate (S1P), PLD, phospholipase D, Molecular Biology, S1P, sphingosine-1-phosphate, 030102 biochemistry & molecular biology, Phospholipase D, Cell Membrane, Cell Biology, Lipid signaling, QR, 030104 developmental biology, mSK1, mouse SK1, Phorbol, biology.protein, BuMe, butanol:methanol, mutagenesis in vitro, lipid signaling, FCS, fetal calf serum, Lysophospholipids, Protein Multimerization, DAPI, 4′,6-diamidino-2-phenylindole

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3396474707d566c93b76fdd17ca71c
http://europepmc.org/articles/PMC8135045