المؤلفون: Mikhail Krasavin, Alexey Lukin, Daria Bagnyukova, Nikolay Zhurilo, Ihor Zahanich, Sergey Zozulya

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 29-36 (2017)

مصطلحات موضوعية: Agonists, cLogP, free fatty acid receptor 1, GPR40, potency, total polar surface area, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/5d8999bb7c674341b63a5e6d5a3ae0a5

المؤلفون: Alexander Safrygin, Elena Zhuravel, Alexey Lukin, Mikhail Krasavin, Anna Bakholdina, Maxim Gureev, Nikolay Zhurilo, Sergey Zozulya, Oleksandra Onopchenko

المصدر: Archiv der PharmazieREFERENCES. 354(4)

مصطلحات موضوعية: Agonist, Stereochemistry, Hydrochloride, medicine.drug_class, Pharmaceutical Science, 01 natural sciences, Receptors, G-Protein-Coupled, In silico docking, chemistry.chemical_compound, Structure-Activity Relationship, Piperidines, Heterocyclic Compounds, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Sulfones, Insulin secretion, Benzofurans, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Rat Insulinoma, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Propanoic acid, FASIGLIFAM, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14101c003a5ef5eaa4b79fdbadb38f34
https://pubmed.ncbi.nlm.nih.gov/33270252

المؤلفون: Alexey Lukin, Natalya Kalinchenkova, Nikolay Zhurilo, Mikhail Krasavin, Tatiana Vedekhina

المصدر: Tetrahedron Letters. 59:2732-2735

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Reagent, Organic Chemistry, Drug Discovery, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Transformation (music), 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9bca044c53593a8d0b8bfdb7d14d534e
https://doi.org/10.1016/j.tetlet.2018.05.075

المؤلفون: Alexei Lukin, Petro Borysko, Daniel Moore, Sergey Zozulya, Anna Bakholdina, Oleksandra Onopchenko, Nikolay Zhurilo, Irina G. Tikhonova, Mikhail Krasavin

المصدر: European Journal of Medicinal Chemistry. 140:229-238

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, CHO Cells, 01 natural sciences, Molecular Docking Simulation, Receptors, G-Protein-Coupled, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Thiadiazoles, Free fatty acid receptor 1, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Chinese hamster ovary cell, Organic Chemistry, General Medicine, biology.organism_classification, 0104 chemical sciences, 030104 developmental biology, Biochemistry, Drug Design

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1a4d5b96170cfc82246f5eb238dccc
https://doi.org/10.1016/j.ejmech.2017.09.019

المؤلفون: Mikhail Krasavin, Alexey Lukin, Nikolay Zhurilo, Daria Bagnyukova

المصدر: Letters in Organic Chemistry. 13:491-495

مصطلحات موضوعية: Agonist, Scale (ratio), 010405 organic chemistry, Chemistry, medicine.drug_class, Organic Chemistry, Parallel computing, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Block (telecommunications), Core (graph theory), medicine, Gram

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bd4e220edc12a1eb2ff1a809cc7dea85
https://doi.org/10.2174/1570178613666160805115331

المؤلفون: Ihor Zahanich, Nikolay Zhurilo, Daniel Moore, Irina G. Tikhonova, Sergey Zozulya, Mikhail Krasavin, Alexey Kovalenko, Alexey Lukin

المصدر: Krasavin, M, Lukin, A, Zhurilo, N, Kovalenko, A, Zahanich, I, Zozulya, S, Moore, D & Tikhonova, I G 2016, ' Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold ', Bioorganic & Medicinal Chemistry, vol. 24, no. 13, pp. 2954–2963 . https://doi.org/10.1016/j.bmc.2016.04.065

مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Carboxamide, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, SDG 3 - Good Health and Well-being, Free fatty acid receptor 1, Thiadiazoles, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Potency, Receptor, Molecular Biology, ADME, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Amides, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Microsomes, Liver, biology.protein, Molecular Medicine, Lead compound, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89595fe64d7deb19d841e9564b325a41
https://doi.org/10.1016/j.bmc.2016.04.065

المؤلفون: Darya Bagnyukova, Natalya Kalinchenkova, Mikhail Krasavin, Nikolay Zhurilo, Alexey Lukin

المصدر: Tetrahedron Letters. 57:3311-3314

مصطلحات موضوعية: Aqueous solution, 010405 organic chemistry, Organic Chemistry, Alcohol, Sulfuric acid, Prins reaction, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0935ed27c710c99412ebdaebe159752f
https://doi.org/10.1016/j.tetlet.2016.06.054

المؤلفون: Alexey Lukin, Mikhail Krasavin, Nikolay Zhurilo, Dmitry Tovpeko, Tatiana Vedekhina

المصدر: RSC Advances. 6:57956-57959

مصطلحات موضوعية: chemistry.chemical_compound, 010405 organic chemistry, Stereochemistry, Chemistry, General Chemical Engineering, Polymer chemistry, General Chemistry, 010402 general chemistry, Protecting group, 01 natural sciences, 0104 chemical sciences, Triazine, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4bcc0ba260f829e8877a515b2044c91c
https://doi.org/10.1039/c6ra12664b

المؤلفون: Markus M. Forsberg, Irene Burghardt, Natalia Kalinchenkova, Jarkko Rautio, Denys Pogoryelov, Igor Konstantinov, Lilia Weizel, Ewgenij Proschak, Mikhail Krasavin, Jukka Leppänen, Darya Bagnyukova, Konstantin Falahati, Jan S. Kramer, Nikolay Zhurilo, Seppo Auriola, Jouni Ihalainen, Victor Hernandez-Olmos, Alexey Lukin, Markus Hartmann, Dmitry Dar'in

المساهمون: Publica

مصطلحات موضوعية: 0301 basic medicine, Epoxide hydrolase 2, Stereochemistry, Biochemistry, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Hydrolase, Humans, Urea, Spiro Compounds, Enzyme Inhibitors, Molecular Biology, IC50, Epoxide Hydrolases, Chemistry, Organic Chemistry, Recombinant Proteins, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Solubility, Lipophilicity, Enantiomer, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d6dc05a12197785600e1612b214988
https://publica.fraunhofer.de/handle/publica/256703

المؤلفون: Alexander N. Prutkov, Mikhail V. Chudinov, Irina D. Konstantinova, Andrey V. Matveev, Vitaly I. Shvets, Anatoly I. Miroshnikov, Olga S. Smirnova, Nikolay Zhurilo, Lyubov E. Grebenkina, Natalya V. Pulkova

المصدر: Bioorganicmedicinal chemistry letters. 28(1)

مصطلحات موضوعية: Cell Survival, viruses, Hepacivirus, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Herpesvirus 1, Human, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Drug Discovery, Chlorocebus aethiops, Ribavirin, Influenza A virus, medicine, Animals, Humans, Molecular Biology, Vero Cells, Cell survival, biology, 010405 organic chemistry, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Virology, digestive system diseases, 0104 chemical sciences, chemistry, Vero cell, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba805ac12a12aaed9453652a8f711af
https://pubmed.ncbi.nlm.nih.gov/29173944