المؤلفون: O'Connell, GD, Nims, RJ, Green, J, Cigan, AD, Ateshian, GA, Hung, CT

مصطلحات موضوعية: Bioengineering, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Musculoskeletal, Animals, Cartilage, Cattle, Cells, Cultured, Chondroitin ABC Lyase, Collagen, Dose-Response Relationship, Drug, Glycosaminoglycans, Regeneration, Time Factors, Tissue Engineering, Cartilage tissue engineering, chondroitinase ABC, collagen, glycosaminoglycans, articular cartilage, enzymatic digestion, dose dependence, Biochemistry and Cell Biology, Biomedical Engineering

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1732g7mm

المؤلفون: Albro MB, Cigan AD, Nims RJ, Yeroushalmi KJ, Oungoulian SR, Hung CT, Ateshian GA, Albro, M B, Cigan, A D, Nims, R J, Yeroushalmi, K J, Oungoulian, S R, Hung, C T, Ateshian, G A

المصدر: Osteoarthritis & Cartilage; Nov2012, Vol. 20 Issue 11, p1374-1382, 9p

المؤلفون: Savadipour A; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Nims RJ; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Rashidi N; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Garcia-Castorena JM; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110.; Division of Biology and Biomedical Sciences, Biochemistry, Biophysics, and Structural Biology Program, Washington University in St. Louis, St. Louis, MO 63110., Tang R; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Marushack GK; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Oswald SJ; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110., Liedtke WB; Department of Neurology, Duke University, Durham, NC 27705.; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010., Guilak F; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63110.; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110.; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO 63110.; Division of Biology and Biomedical Sciences, Biochemistry, Biophysics, and Structural Biology Program, Washington University in St. Louis, St. Louis, MO 63110.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 25; Vol. 120 (30), pp. e2221958120. Date of Electronic Publication: 2023 Jul 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Chondrocytes*/metabolism , Osteoarthritis*/metabolism, Humans ; Ion Channels/metabolism ; Joints ; Mechanotransduction, Cellular ; Calcium Signaling

المؤلفون: Nims RJ; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Shriners Hospitals for Children - Saint Louis, St. Louis, MO, 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Pferdehirt L; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Shriners Hospitals for Children - Saint Louis, St. Louis, MO, 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, 63105, USA., Guilak F; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA; Shriners Hospitals for Children - Saint Louis, St. Louis, MO, 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, 63105, USA. Electronic address: guilak@wustl.edu.

المصدر: Current opinion in biotechnology [Curr Opin Biotechnol] 2022 Feb; Vol. 73, pp. 374-379. Date of Electronic Publication: 2021 Nov 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9100492 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0429 (Electronic) Linking ISSN: 09581669 NLM ISO Abbreviation: Curr Opin Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Engineering* , Mechanotransduction, Cellular*, Animals ; Biophysics ; Mammals ; Signal Transduction/genetics ; Synthetic Biology

المؤلفون: Savadipour A; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Shriners Hospitals for Children, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, USA., Nims RJ; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Shriners Hospitals for Children, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA., Katz DB; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Shriners Hospitals for Children, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA., Guilak F; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Shriners Hospitals for Children, St. Louis, MO, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.

المصدر: Connective tissue research [Connect Tissue Res] 2022 Jan; Vol. 63 (1), pp. 69-81. Date of Electronic Publication: 2021 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0365263 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8438 (Electronic) Linking ISSN: 03008207 NLM ISO Abbreviation: Connect Tissue Res Subsets: MEDLINE

مواضيع طبية MeSH: Cartilage, Articular*/metabolism , Transient Receptor Potential Channels*/metabolism, Animals ; Cells, Cultured ; Chondrocytes/metabolism ; Chondrogenesis ; Glycosaminoglycans/metabolism ; Hydrostatic Pressure ; Swine ; TRPV Cation Channels/metabolism

المؤلفون: Klimak M; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Nims RJ; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Pferdehirt L; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Collins KH; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Harasymowicz NS; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Oswald SJ; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Setton LA; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA., Guilak F; Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA; Shriners Hospitals for Children - St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University, St. Louis, MO 63110, USA. Electronic address: guilak@wustl.edu.

المصدر: Acta biomaterialia [Acta Biomater] 2021 Oct 01; Vol. 133, pp. 74-86. Date of Electronic Publication: 2021 Apr 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Rheumatoid*/therapy , Osteoarthritis*/therapy, Biocompatible Materials ; Humans ; Immunomodulation ; Immunotherapy

المؤلفون: Zimmerman BK; Department of Mechanical Engineering, Columbia University, New York, NY 10027., Nims RJ; Department of Biomedical Engineering, Columbia University, New York, NY 10027., Chen A; Department of Mechanical Engineering, Columbia University, New York, NY 10027., Hung CT; Department of Biomedical Engineering, Columbia University, New York, NY 10027., Ateshian GA; Department of Mechanical Engineering, Columbia University, New York, NY 10027; Department of Biomedical Engineering, Columbia University, New York, NY 10027.

المصدر: Journal of biomechanical engineering [J Biomech Eng] 2021 Apr 01; Vol. 143 (4).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society Of Mechanical Engineers Country of Publication: United States NLM ID: 7909584 Publication Model: Print Cited Medium: Internet ISSN: 1528-8951 (Electronic) Linking ISSN: 01480731 NLM ISO Abbreviation: J Biomech Eng Subsets: MEDLINE

مواضيع طبية MeSH: Cartilage, Articular*

المؤلفون: Lee W; Department of Neurology, Duke University, Durham, NC 27710; whasil_lee@urmc.rochester.edu wolfgang@neuro.duke.edu.; Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620.; Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14620., Nims RJ; Department of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110., Savadipour A; Department of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110., Zhang Q; Department of Neurology, Duke University, Durham, NC 27710., Leddy HA; Department of Orthopedics, Duke University, Durham, NC 27710., Liu F; Department of Neurobiology, Duke University, Durham, NC 27710., McNulty AL; Department of Orthopedics, Duke University, Durham, NC 27710., Chen Y; Department of Neurology, Duke University, Durham, NC 27710., Guilak F; Department of Orthopaedic Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.; Center of Regenerative Medicine, Washington University School of Medicine in Saint Louis, St. Louis, MO 63110.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110., Liedtke WB; Department of Neurology, Duke University, Durham, NC 27710; whasil_lee@urmc.rochester.edu wolfgang@neuro.duke.edu.; Department of Neurobiology, Duke University, Durham, NC 27710.; Department of Anesthesiology, Duke University, Durham, NC 27710.; Neurology Clinics for Headache, Head-Pain and Trigeminal Sensory Disorders, Duke University School of Medicine, Durham, NC 27705.; Innovative Pain Therapy Clinics, Duke University School of Medicine, Raleigh, NC 27716.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 30; Vol. 118 (13).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Chondrocytes/*metabolism , Interleukin-1alpha/*metabolism , Ion Channels/*genetics , Mechanotransduction, Cellular/*immunology , Osteoarthritis/*immunology, Activating Transcription Factor 2/metabolism ; Animals ; Calcium/metabolism ; Cartilage, Articular/cytology ; Cartilage, Articular/immunology ; Cartilage, Articular/pathology ; Cells, Cultured ; Chondrocytes/immunology ; Female ; Gene Knockdown Techniques ; Humans ; Ion Channels/metabolism ; Mechanotransduction, Cellular/genetics ; Osteoarthritis/genetics ; Osteoarthritis/pathology ; Primary Cell Culture ; Promoter Regions, Genetic/genetics ; Sus scrofa ; Up-Regulation/immunology

المؤلفون: Nims RJ; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Pferdehirt L; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA., Ho NB; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Biology, Duke University, Durham, NC 27708, USA., Savadipour A; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63105, USA., Lorentz J; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA., Sohi S; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA., Kassab J; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA., Ross AK; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA., O'Conor CJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Liedtke WB; Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA., Zhang B; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., McNulty AL; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA., Guilak F; Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA. guilak@wustl.edu.; Shriners Hospitals for Children-Saint Louis, St. Louis, MO 63110, USA.; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University, St. Louis, MO 63105, USA.; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63105, USA.

المصدر: Science advances [Sci Adv] 2021 Jan 27; Vol. 7 (5). Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products*/metabolism , TRPV Cation Channels*/metabolism, Chondrocytes/metabolism ; Gene Regulatory Networks ; Tissue Engineering

المؤلفون: Durney KM; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Shaeffer CA; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Zimmerman BK; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Nims RJ; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Oungoulian S; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Jones BK; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Boorman-Padgett JF; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Suh JT; Department of Mechanical Engineering, Columbia University, New York, NY, USA., Shah RP; Department of Orthopaedic Surgery, Columbia University, New York, NY, USA., Hung CT; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Ateshian GA; Department of Biomedical Engineering, Columbia University, New York, NY, USA; Department of Mechanical Engineering, Columbia University, New York, NY, USA. Electronic address: ateshian@columbia.edu.

المصدر: Journal of biomechanics [J Biomech] 2020 Jun 23; Vol. 107, pp. 109852. Date of Electronic Publication: 2020 May 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0157375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2380 (Electronic) Linking ISSN: 00219290 NLM ISO Abbreviation: J Biomech Subsets: MEDLINE

مواضيع طبية MeSH: Cartilage, Articular*, Animals ; Cattle ; Friction ; Humans ; Stress, Mechanical ; Synovial Fluid ; Tibia