المؤلفون: Alpar, A, Tortoriello, G, Calvigioni, D, Niphakis, MJ, Milenkovic, I, Bakker, J, Cameron, GA, Hanics, J, Morris, CV, Fuzik, J, Kovacs, GG, Cravatt, BF, Parnavelas, JG, Andrews, WD, Hurd, YL, Keimpema, E, Harkany, T

المصدر: Nature communications. 5:4421

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:129626131

المؤلفون: Yan S; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Santoro A; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Niphakis MJ; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Pinto AM; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Jacobs CL; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Ahmad R; Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., Kuwait City, Kuwait., Suciu RM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Fonslow BR; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst-Graham RA; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Ngo N; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Henry CL; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst DM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Saghatelian A; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Kahn BB; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA., Rosen ED; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. erosen@bidmc.harvard.edu.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA. erosen@bidmc.harvard.edu.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA. erosen@bidmc.harvard.edu.

المصدر: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4605. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance* , Interferon Regulatory Factor-3*/metabolism , Interferon Regulatory Factor-3*/genetics , Obesity*/metabolism , Diet, High-Fat*/adverse effects , Inflammation*/metabolism , Mice, Knockout* , Adipocytes*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Glucose/metabolism ; 3T3-L1 Cells

المؤلفون: League AF; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Yadav-Samudrala BJ; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Kolagani R; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Cline CA; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Jacobs IR; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Manke J; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Niphakis MJ; Department of Chemistry, Scripps Research, La Jolla, CA, United States., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, United States., Lichtman AH; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States., Ignatowska-Jankowska BM; Neuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Okinawa, Japan., Fitting S; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

المصدر: Frontiers in immunology [Front Immunol] 2024 May 21; Vol. 15, pp. 1374301. Date of Electronic Publication: 2024 May 21 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: HIV-1*/physiology , Monoacylglycerol Lipases*/antagonists & inhibitors , Monoacylglycerol Lipases*/metabolism , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/etiology, Animals ; Female ; Humans ; Mice ; AIDS Dementia Complex/drug therapy ; Brain/drug effects ; Brain/metabolism ; Brain/virology ; Brain/pathology ; Disease Models, Animal ; HIV Infections/drug therapy ; Mice, Transgenic ; Microglia/drug effects ; Microglia/metabolism ; tat Gene Products, Human Immunodeficiency Virus/metabolism

المؤلفون: Dixon CL, Martin NR, Niphakis MJ, Cravatt BF, Fairn GD

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 21. Date of Electronic Publication: 2023 Dec 21.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Keller LJ; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA., Nguyen TH; Department of Bioengineering, Stanford University, Stanford, CA, USA., Liu LJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Hurysz BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Lakemeyer M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University, Jena, Germany., Guerra M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Biochemical and Cellular Pharmacology, Genentech, San Francisco, CA, USA., Gelsinger DJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Chanin R; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Divisions of Hematology and Blood and Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA, USA., Ngo N; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Lum KM; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Faucher F; Department of Chemistry, Stanford University, Stanford, CA, USA., Ipock P; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Niphakis MJ; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Bhatt AS; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Divisions of Hematology and Blood and Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA, USA., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Huang KC; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Bogyo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. mbogyo@stanford.edu.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. mbogyo@stanford.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2023 Dec; Vol. 19 (12), pp. 1469-1479. Date of Electronic Publication: 2023 Jun 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Bacteroides thetaiotaomicron* , Diabetes Mellitus, Type 2*, Humans ; Dipeptidyl Peptidase 4/genetics ; Serine

المؤلفون: Xu C; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Yadav-Samudrala BJ; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Xu C; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Nath B; Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC 27707, USA., Mistry T; Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC 27707, USA., Jiang W; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA., Niphakis MJ; Department of Chemical Physiology, Scripps Research Institute, La Jolla, CA 92037, USA., Cravatt BF; Department of Chemical Physiology, Scripps Research Institute, La Jolla, CA 92037, USA., Mukhopadhyay S; Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC 27707, USA., Lichtman AH; Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA., Ignatowska-Jankowska BM; Neuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Onna 904-0495, Japan., Fitting S; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

المصدر: Cells [Cells] 2022 Mar 02; Vol. 11 (5). Date of Electronic Publication: 2022 Mar 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Cannabinoids*/pharmacology , HIV Infections*, Amidohydrolases ; Animals ; Endocannabinoids/metabolism ; Enzyme Inhibitors ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Piperidines ; Pyridines ; Receptors, Cannabinoid ; Synaptic Transmission ; tat Gene Products, Human Immunodeficiency Virus/metabolism

المؤلفون: Onguka O; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Babin BM; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Lakemeyer M; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Foe IT; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Amara N; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Terrell SM; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA., Lum KM; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Cieplak P; Infectious & Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Niphakis MJ; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Long JZ; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA., Bogyo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: mbogyo@stanford.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2021 Oct 21; Vol. 28 (10), pp. 1501-1513.e5. Date of Electronic Publication: 2021 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Metabolism/*physiology , Protozoan Proteins/*metabolism , Serine Endopeptidases/*metabolism , Toxoplasma/*enzymology, Amino Acid Sequence ; Catalytic Domain ; Hydrolysis ; Kinetics ; Phylogeny ; Protozoan Proteins/classification ; Protozoan Proteins/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Sequence Alignment ; Serine Endopeptidases/classification ; Serine Endopeptidases/genetics ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Substrate Specificity ; Toxoplasma/growth & development ; Toxoplasma/physiology

المؤلفون: League AF; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Gorman BL; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Hermes DJ; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Johnson CT; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Jacobs IR; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Yadav-Samudrala BJ; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States., Poklis JL; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States., Niphakis MJ; Department of Chemistry, Scripps Research Institute, La Jolla, CA, United States., Cravatt BF; Department of Chemistry, Scripps Research Institute, La Jolla, CA, United States., Lichtman AH; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States., Ignatowska-Jankowska BM; Okinawa Institute of Science and Technology, Neuronal Rhythms in Movement Unit, Okinawa, Japan., Fitting S; Department of Psychology and Neuroscience, University of North Carolina Chapel Hill, Chapel Hill, NC, United States.

المصدر: Frontiers in neurology [Front Neurol] 2021 Aug 16; Vol. 12, pp. 651272. Date of Electronic Publication: 2021 Aug 16 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE

المؤلفون: Remsberg JR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Suciu RM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Zambetti NA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Hanigan TW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Firestone AJ; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Inguva A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Long A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Ngo N; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Lum KM; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Henry CL; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Richardson SK; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Predovic M; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Huang B; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Dix MM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Howell AR; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Niphakis MJ; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA. MIIP@lundbeck.com., Shannon K; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2021 Aug; Vol. 17 (8), pp. 856-864. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*metabolism , Hydrolases/*metabolism , Leukemia, Myeloid, Acute/*metabolism , Leukemia, Promyelocytic, Acute/*metabolism , ras Proteins/*metabolism, Cell Proliferation ; Cells, Cultured ; Humans ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Promyelocytic, Acute/pathology ; Lipoylation ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure

المؤلفون: Mizrak D; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Bayin NS; Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA., Yuan J; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Liu Z; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Suciu RM; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Niphakis MJ; Lundbeck La Jolla Research Center, Inc., 10835 Road to the Cure, Suite 250, San Diego, CA 92121, USA., Ngo N; Lundbeck La Jolla Research Center, Inc., 10835 Road to the Cure, Suite 250, San Diego, CA 92121, USA., Lum KM; Lundbeck La Jolla Research Center, Inc., 10835 Road to the Cure, Suite 250, San Diego, CA 92121, USA., Cravatt BF; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Joyner AL; Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Biochemistry, Cell and Molecular Biology Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: pas2182@cumc.columbia.edu.

المصدر: Cell reports [Cell Rep] 2020 Jun 23; Vol. 31 (12), pp. 107805.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cell Lineage* , Neurogenesis* , Single-Cell Analysis*, Aging/*metabolism , Esterases/*metabolism , Lateral Ventricles/*cytology, Animals ; Cell Proliferation ; Gene Expression Regulation ; Genes, Reporter ; Mice, Inbred C57BL ; Neurons/metabolism ; Olfactory Bulb/cytology