المؤلفون: Emre Guney, Mahmoud H. Elbatreek, Harald H.H.W. Schmidt, Jan Baumbach, Javier Egea, Simon J. Larsen, Vanessa Gómez-Rangel, Ana I. Casas, Pamela W. M. Kleikers, Manuela G. López, Ahmed A. Hassan

المساهمون: Pharmacology and Personalised Medicine, RS: FHML non-thematic output

المصدر: Casas, A I, Hassan, A A, Larsen, S J, Gomez-Rangel, V, Elbatreek, M, Kleikers, P W M, Guney, E, Egea, J, López, M G, Baumbach, J & Schmidt, H H H W 2019, ' From single drug targets to synergistic network pharmacology in ischemic stroke ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7129-7136 . https://doi.org/10.1073/pnas.1820799116
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences

مصطلحات موضوعية: 0301 basic medicine, Male, PREDICTION, Pyrazoles/pharmacology, Nitric Oxide Synthase Type II, Disease, Nitric Oxide Synthase Type I, OXYGEN, Brain Ischemia, Mice, 0302 clinical medicine, Cell Death/drug effects, Drug Discovery, Nitric Oxide Synthase Type II/genetics, Nitric Oxide Synthase/drug effects, BRAIN, Stroke, network analysis, media_common, Multidisciplinary, NADPH oxidase, biology, Cell Death, Drug discovery, NOX4, Drug Synergism, Biological Sciences, stroke, ddc, 3. Good health, Drug Combinations, NG-Nitroarginine Methyl Ester, PNAS Plus, Blood-Brain Barrier, NADPH Oxidase 4, SIMILARITY, Nitric Oxide Synthase Type III/genetics, Network analysis, Female, Stroke/drug therapy, Blood-Brain Barrier/metabolism, Drug, EXPRESSION, Nitric Oxide Synthase Type III, Pyridones, media_common.quotation_subject, NOS1, BIOLOGY, 03 medical and health sciences, HYDROGEN-PEROXIDE, In vivo, Reactive Oxygen Species/metabolism, medicine, network pharmacology, Animals, NG-Nitroarginine Methyl Ester/pharmacology, Pyridones/pharmacology, Pharmacology, NITRIC-OXIDE, business.industry, NADPH Oxidase 4/drug effects, Brain Ischemia/drug therapy, medicine.disease, OFF-TARGET, Disease Models, Animal, 030104 developmental biology, CELLS, biology.protein, Pyrazoles, Nitric Oxide Synthase Type I/genetics, Nitric Oxide Synthase, business, Reactive Oxygen Species, Neuroscience, 030217 neurology & neurosurgery, Network pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd3be0432e66a4fc3c69b16682fec9
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf

المؤلفون: Tugba Boyunegmez Tumer, Ibrahim Demirtas, Seda Savranoglu Kulabas, R. Ekren, Hande Ipek, Ali Rıza Tüfekçi, Sevki Arslan, Ugur Sezerman

مصطلحات موضوعية: medicine.medical_treatment, Peroxisome proliferator-activated receptor, animal cell, Pharmacology, transcriptomics, Mice, 0302 clinical medicine, Drug Discovery, Caffeic acid, genetics, cyclooxygenase 2, lavender, C2C12 cell line, chemistry.chemical_classification, adipocyte cell line, aerial plant part, drug effect, peroxisome proliferator activated receptor gamma, gene expression regulation, time of flight mass spectrometry, 3. Good health, Lavandula, 030220 oncology & carcinogenesis, Glucose-6-Phosphatase, Lavandula stoechas, antiinflammatory agent, H4-II-E cell line, glucose 6 phosphatase, insulin, in vitro study, Glucose uptake, Lipolysis, lipoprotein lipase, Nitric Oxide, Article, 03 medical and health sciences, protein serine threonine kinase, Lavandula stoechas extract, luteolin, Protein kinase B, mouse, Animals, Cell Line, Cell Line, Tumor, Cell Survival/drug effects, Cyclooxygenase 2/genetics, Gene Expression Regulation/drug effects, Glucose/metabolism, Glucose-6-Phosphatase/genetics, Interleukin-1beta/genetics, Lipolysis/drug effects, Metabolic Syndrome/drug therapy, Nitric Oxide/metabolism, Nitric Oxide Synthase Type II/genetics, PPAR gamma/metabolism, Plant Components, Aerial, Plant Extracts/*pharmacology, Protein-Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins, antiinflammatory activity, medicine.disease, 030104 developmental biology, chemistry, phosphoenolpyruvate carboxylase kinase, Metabolic syndrome, metformin, 0301 basic medicine, interleukin 1beta, Interleukin-1beta, Nitric Oxide Synthase Type II, chemistry.chemical_compound, 4 hydroxybenzoic acid, animal, rat, glucose, isoprenaline, Metabolic Syndrome, biology, messenger RNA, cell line, Protein-Serine-Threonine Kinases, unclassified drug, plant extract, rosmarinic acid, high performance liquid chromatography, Cell Survival, salicylic acid, Protein Serine-Threonine Kinases, Insulin resistance, medicine, drug mechanism, controlled study, apigenin, nonhuman, Plant Extracts, Insulin, Gluconeogenesis, inducible nitric oxide synthase, tumor cell line, glucose transport, RAW 264.7 cell line, biology.organism_classification, Rats, PPAR gamma, vanillic acid, protein kinase B, myotube, metabolic syndrome X, Transcriptome, caffeic acid, metabolism, Proto-Oncogene Proteins c-akt, ferulic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ddd8d9771ed4c565a90da929fbb06

المؤلفون: Nicolas Fasel, Ulisses Gazos Lopes, Gabrielle B L Silva, Áislan de Carvalho Vivarini, Carolina Torturella Rath, José Vitorino dos Santos, Renata M. Pereira, Teresa Cristina Calegari-Silva, Alessandra Mattos Saliba, Carlos Eduardo Pereira Corbett, Karina Luiza Dias-Teixeira, Amanda S S Pacheco, Charlene A S Pinto, Claudia Maria de Castro Gomes

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
European journal of immunology, vol. 48, no. 7, pp. 1188-1198

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, animal structures, Adolescent, Sp1 Transcription Factor, 030106 microbiology, Immunology, Cells, Cultured, Child, Extinction, Biological, Female, Histone Deacetylase 1/genetics, Histone Deacetylase 1/metabolism, Host-Parasite Interactions, Humans, Immune Evasion, Leishmania braziliensis/physiology, Leishmaniasis, Cutaneous/genetics, Leishmaniasis, Cutaneous/immunology, Macrophages/immunology, Middle Aged, Nitric Oxide/metabolism, Nitric Oxide Synthase Type II/genetics, Nitric Oxide Synthase Type II/metabolism, Parasite Load, Promoter Regions, Genetic/genetics, Protein Binding, RNA, Small Interfering/genetics, Skin/pathology, Sp1 Transcription Factor/metabolism, Young Adult, HDAC1, Leishmaniasis, Macrophage, Parasitse, Leishmaniasis, Cutaneous, Nitric Oxide Synthase Type II, Histone Deacetylase 1, Biology, Nitric Oxide, Leishmania braziliensis, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Downregulation and upregulation, Gene expression, Immunology and Allergy, Gene silencing, RNA, Small Interfering, Promoter Regions, Genetic, Skin, Macrophages, Leishmania, biology.organism_classification, Molecular biology, Nitric oxide synthase, 030104 developmental biology, chemistry, biology.protein, CROMATINA, Intracellular

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8ac4e7c7cd8865a82b83be8e071c51

المؤلفون: Andrea M. Cooper, Manuela Flórido, António G. Castro, Margarida Borges, Mariana Resende, Ana R. Ribeiro, Marcos S. Cardoso, Nuno L. Alves, Rui Appelberg

المساهمون: Instituto de Investigação e Inovação em Saúde, Universidade do Minho

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Nitric Oxide Synthase Type II/immunology, Myeloid, Mycobacterium avium/growth & development, Liver cytology, Nitric Oxide Synthase Type II/biosynthesis, medicine.medical_treatment, Medicina Básica [Ciências Médicas], Nitric Oxide Synthase Type II, Macrophages/immunology, Mice, 0302 clinical medicine, Liver/immunology, Spleen/cytology, Immunology and Allergy, Interferon gamma, IL-2 receptor, Interleukin Receptor Common gamma Subunit/deficiency, Nitric Oxide Synthase Type II/genetics, Granuloma/immunology, Thy-1 Antigens/immunology, Granuloma, Innate lymphoid cell, Interleukin Receptor Common gamma Subunit/genetics, Antibodies, Monoclonal, Liver/microbiology, 3. Good health, DNA-Binding Proteins, Killer Cells, Natural, Haematopoiesis, Cytokine, medicine.anatomical_structure, Liver, Killer Cells, Natural/immunology, Ciências Médicas::Medicina Básica, Thy-1 Antigens/genetics, medicine.drug, Leukocyte Common Antigens/immunology, Interleukin Receptor Common gamma Subunit, Spleen/immunology, Immunology, Liver/cytology, chemical and pharmacologic phenomena, Biology, Antibodies, Monoclonal/administration & dosage, 03 medical and health sciences, Immunocompromised Host, Interferon-gamma, Interferon-gamma/biosynthesis, medicine, Animals, Immunocompromised Host/immunology, DNA-Binding Proteins/immunology, Granuloma/microbiology, Interferon-gamma/genetics, Interleukin Receptor Common gamma Subunit/immunology, Science & Technology, Lineage markers, Hematopoietic Stem Cells/immunology, Macrophages, Hematopoietic Stem Cells, Molecular biology, Immunity, Innate, Leukocyte Common Antigens/genetics, Mice, Inbred C57BL, 030104 developmental biology, Interferon-gamma/immunology, Leukocyte Common Antigens, Thy-1 Antigens, DNA-Binding Proteins/deficiency, Mycobacterium avium/immunology, DNA-Binding Proteins/genetics, Spleen, 030215 immunology, Mycobacterium avium

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc258643b602938694e1a0a60f84973

المؤلفون: Romana T. Hartl, Erich Gnaiger, Thomas Ebel, Heinz Redl, Peter Radermacher, Soheyl Bahrami, Susanne Haindl, J. Catharina Duvigneau, Martijn van Griensven, Mohammad Jafarmadar, Andrey V. Kozlov, Enrico Calzia, Ingeborg Kehrer

المصدر: Inflammation. 33(5):295-305

مصطلحات موضوعية: Mitochondrial ROS, Male, Pathology, Kidney/immunology, Time Factors, Mitochondria/immunology, Peritonitis/genetics, Sus scrofa, Oxidative Stress/genetics, Nitric Oxide Synthase Type II, Mitochondria, Liver, Messenger/metabolism, Mitochondrion, Kidney, medicine.disease_cause, Heme Oxygenase-1/genetics, chemistry.chemical_compound, Liver/immunology, Immunology and Allergy, Nitric Oxide Synthase Type II/genetics, Mitochondria, medicine.anatomical_structure, Female, Inflammation Mediators, medicine.symptom, medicine.medical_specialty, Iron, Immunology, Cell Respiration, Inflammation, Peritonitis, Biology, Nitric Oxide, Nitric oxide, Reactive Oxygen Species/metabolism, Internal medicine, medicine, Animals, RNA, Messenger, Tumor Necrosis Factor-alpha, Animal, Hemodynamics, Kidney metabolism, Heme oxygenase, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Inflammation Mediators/metabolism, Nitric Oxide/metabolism, Disease Models, RNA, Tumor Necrosis Factor-alpha/genetics, Reactive Oxygen Species, Iron/metabolism, Heme Oxygenase-1, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d334e477e35fdc293041722c6fa59b5c
https://cris.maastrichtuniversity.nl/en/publications/2f396288-da9d-41fd-9d59-e41847b7506f

المؤلفون: Petersson, Joel, Phillipson, Mia, Jansson, Emmelie A, Patzak, Andreas, Lundberg, Jon O, Holm, Lena

المصدر: American Journal of Physiology - Gastrointestinal and Liver Physiology. 292(3):G718-G724

مصطلحات موضوعية: Administration, Oral, Animals, Blood Pressure/drug effects, Diclofenac/administration & dosage/pharmacology, Gastric Mucosa/blood supply/*drug effects/physiology, Male, Mice, Inbred C57BL, Knockout, Mucus/chemistry/drug effects/metabolism, Nitrates/administration & dosage/*pharmacology, Nitric Oxide/metabolism, Nitric Oxide Synthase Type II/genetics, Nitrites/administration & dosage/metabolism/pharmacology, Permeability/drug effects, Rats, Sprague-Dawley, Regional Blood Flow/drug effects, Stomach/drug effects/metabolism, Taurocholic Acid/administration & dosage/pharmacology, Vascular Resistance/drug effects/physiology, MEDICINE, MEDICIN

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13068
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17082222&dopt=Citation

المؤلفون: Söderberg, Malin, Lang, Matti A.

المصدر: Molecular Biotechnology. 32(1):65-71

مصطلحات موضوعية: 3' Untranslated Regions/genetics, Animals, Binding Sites/genetics, Cytoplasm/metabolism, DNA/genetics/metabolism, Gene Deletion, Heterogeneous-Nuclear Ribonucleoproteins/metabolism, Humans, Liver/metabolism, Male, Mice, Inbred DBA, Mutagenesis, Site-Directed/*methods, Nitric Oxide Synthase Type II/genetics, Polymerase Chain Reaction/methods, Protein Binding/genetics, Pyrimidine Nucleotides/*genetics, RNA, Messenger/genetics/metabolism, Repetitive Sequences, Nucleic Acid/*genetics, Reproducibility of Results

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93759

المؤلفون: Imene Soufli, Chafia Touil-Boukoffa, Hayet Rafa, Nadira Delhem, Ryma Toumi, Houria Saoula, Yvan de Launoit, M’hamed Nakmouche, Olivier Moralès, Oussama Medjeber, Mourad Belkhelfa

المساهمون: Laboratoire de Biologie Cellulaire et Moléculaire, Université des Sciences et de la Technologie Houari Boumediene [Alger] (USTHB), Department of Gastroenterology [hôpital Maillot, Algers], Hôpital Maillot [Algérie], Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), This work was supported by a grant from the ANDRS (National Agency for Scientific Development and Research in Health) Project No.03/06/01/10/011)., We thank the technical and surgical staff of the Department of Gastroenterology, Maillot Hospital, Algiers, Algeria, for providing blood and colonic biopsies. We thank all voluntary participants in this study., Mécanismes de tumorigenèse et thérapies ciblées, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Interferon and Cytokine Research
Journal of Interferon and Cytokine Research, Mary Ann Liebert, 2013, 33 (7), pp.355-368. ⟨10.1089/jir.2012.0063⟩

مصطلحات موضوعية: Male, MESH: Interleukin-17/blood, MESH: Th17 Cells/drug effects, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Nitric Oxide Synthase Type II, medicine.disease_cause, Inflammatory bowel disease, Interleukin-23, Pathogenesis, MESH: Nitric Oxide Synthase Type II/genetics, 0302 clinical medicine, T-Lymphocyte Subsets, MESH: Nitric Oxide/metabolism, STAT3, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, MESH: Middle Aged, biology, MESH: Interleukin-17/metabolism, Interleukin-17, MESH: Nitric Oxide Synthase Type II/metabolism, Interleukin, MESH: Interleukin-23/metabolism, Middle Aged, 3. Good health, Cytokine, MESH: T-Lymphocyte Subsets/drug effects, MESH: Young Adult, 030220 oncology & carcinogenesis, MESH: Interleukin-23/blood, Female, MESH: Algeria, MESH: STAT3 Transcription Factor/genetics, Signal Transduction, MESH: Cells, Cultured, Adult, STAT3 Transcription Factor, Immunology, Tretinoin, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Immunomodulation, Nitric Oxide, Peripheral blood mononuclear cell, Proinflammatory cytokine, Immunomodulation, 03 medical and health sciences, Young Adult, MESH: Signal Transduction/drug effects, MESH: T-Lymphocyte Subsets/immunology, MESH: Tretinoin/therapeutic use, Virology, medicine, Humans, Receptors, Cytokine, 030304 developmental biology, MESH: Interleukin-6/blood, MESH: Humans, Interleukin-6, MESH: Interleukin-6/metabolism, MESH: Th17 Cells/immunology, MESH: Adult, Cell Biology, Immune dysregulation, medicine.disease, Inflammatory Bowel Diseases, MESH: Receptors, Cytokine/genetics, MESH: Gene Expression Regulation/drug effects, MESH: Male, MESH: Inflammatory Bowel Diseases/drug therapy, MESH: Inflammatory Bowel Diseases/immunology, Gene Expression Regulation, MESH: STAT3 Transcription Factor/metabolism, Algeria, MESH: Receptors, Cytokine/metabolism, biology.protein, Th17 Cells, MESH: Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a681e8219310a30fbf46f18c46e3e251
https://hal.archives-ouvertes.fr/hal-02395835

المؤلفون: Abdelkrim Hmadcha, Christian Claude Lachaud, Tim Guilliams, Adahir Labrador-Garrido, David Pozo, Elena Gonzalez-Rey, Cintia Roodveldt, Alicia Benitez-Rondan, Christopher M. Dobson, Rafael Fernandez-Montesinos, Gema Robledo, Mario Delgado

المساهمون: [Roodveldt,C, Labrador-Garrido,A, Lachaud,CC, Fernandez-Montesinos,R, Benitez-Rondan,A, Hmadcha A, Pozo,D] CABIMER, Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain. [Labrador-Garrido,A, Pozo,D] Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain. [Gonzalez-Rey,E, Robledo,G Delfgadno,M] Institute of Parasitology and Biomedicine ‘Lopez-Neyra’, CSIC, Granada, Spain. [Dobson,CM] Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, Financial support was provided by the Spanish Ministry of Science and Innovation-Carlos III Institute of Health according to the ‘Plan Nacional de I+D+i 2008-2011’ (PS09-2252 to DP, and CP10/00527 to CR) with co-funding by FEDER funds, the Andalusian Ministry of Health (PI-2010-0824 to DP), Economy, Science and Innovation (P10-CTS-6928 and P11-CTS-8161 to DP) and the PAIDI Program from the Andalusian Government (CTS-677 to DP). ALG holds a FPU Predoctoral Fellowship from the Spanish Ministry of Education (AP-2009/3816)., H-0903, Parkinson's UK, United Kingdom, Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla. CTS-541 Neuroinmunología de Enfermedades Inflamatorias, Autoinmunes y Neurodegenerativas, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Wellcome Trust, Biotechnology and Biological Sciences Research Council (UK), Parkinson's Disease Society (UK)

المصدر: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE, Vol 8, Iss 11, p e79160 (2013)
PLoS ONE

مصطلحات موضوعية: Male, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred C57BL [Medical Subject Headings], Gene Expression, Nitric Oxide Synthase Type II, lcsh:Medicine, Organisms::Bacteria::Gram-Positive Bacteria::Bacillales::Bacillaceae::Bacillus::Bacillus subtilis [Medical Subject Headings], Stimulation, alpha-Synuclein / physiology, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression [Medical Subject Headings], Fluorescence imaging, chemistry.chemical_compound, Mice, 0302 clinical medicine, Arginase / metabolism, Organisms::Eukaryota::Animals [Medical Subject Headings], Microglia / immunology, Receptor, lcsh:Science, Cells, Cultured, Poly I-C / pharmacology, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Aminoquinolines [Medical Subject Headings], Fluorescence microscopy, 0303 health sciences, Toll-like receptor, Multidisciplinary, Imiquimod, Microglia, Caspase 3, Nitric Oxide Synthase Type II / metabolism, Toll-Like Receptors, Cell Polarity, Citocinas, Toll-Like Receptors / agonists, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-Synuclein [Medical Subject Headings], Microscopía Fluorescente, 3. Good health, Peptidoglycan / pharmacology, medicine.anatomical_structure, Nitric Oxide Synthase Type II / genetics, Microglia / metabolism, Aminoquinolines, alpha-Synuclein, Cytokines, Chemokines, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Ureohydrolases::Arginase [Medical Subject Headings], Research Article, Bacillus subtilis, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amino Acid Oxidoreductases::Nitric Oxide Synthase::Nitric Oxide Synthase Type II [Medical Subject Headings], Toll-Like Receptors / metabolism, Aminoquinolines / pharmacology, Check Tags::Male [Medical Subject Headings], Peptidoglycan, Biology, Gene Expression / immunology, 03 medical and health sciences, Phagocytosis, Phenomena and Processes::Cell Physiological Phenomena::Cell Polarity [Medical Subject Headings], medicine, Caspase 3 / metabolism, Animals, Arginase / genetics, Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innate [Medical Subject Headings], Fagocitosis, Anatomy::Cells::Neuroglia::Microglia [Medical Subject Headings], Neuroinflammation, Secretion, 030304 developmental biology, Alpha-synuclein, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines [Medical Subject Headings], Receptores Toll-Like, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Arginase, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Apoptosis Regulatory Proteins::Caspases::Caspases, Effector::Caspase 3 [Medical Subject Headings], lcsh:R, TLR7, Immunity, Innate, Mice, Inbred C57BL, TLR2, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Glycopeptides::Peptidoglycan [Medical Subject Headings], Poly I-C, Cytokines / metabolism, chemistry, Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides::Polynucleotides::Polyribonucleotides::Poly C::Poly I-C [Medical Subject Headings], Anatomy::Cells::Cells, Cultured [Medical Subject Headings], Immunology, lcsh:Q, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Pattern Recognition::Toll-Like Receptors [Medical Subject Headings], 030217 neurology & neurosurgery, Microglial cells

وصف الملف: application/pdf; image/tiff

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3adda19e78432ea6d60a5e249deb675
https://hdl.handle.net/10668/2279

المؤلفون: Tanioka, Toshihiro, Tamura, Yoshiaki, Fukaya, Makiko, Shinozaki, Shohei, Mao, Ji, Kim, Minhye, Shimizu, Nobuyuki, Kitamura, Tadahiro, Kaneki, Masao

المصدر: The Journal of biological chemistry, 286 (33

مصطلحات موضوعية: Glycogen Synthase Kinase 3 -- antagonists & inhibitors -- genetics -- metabolism, Insulin Receptor Substrate Proteins -- biosynthesis -- genetics, Enzyme Activation -- drug effects -- physiology, Nitric Oxide Synthase Type II -- genetics -- metabolism, Sciences bio-médicales et agricoles, Rats, Mice, Interleukin-1beta -- genetics -- metabolism, Gene Expression Regulation -- drug effects -- physiology, Cell Line, Tumor, Proteasome Endopeptidase Complex -- genetics -- metabolism, Leupeptins -- pharmacology, Animals, Humans, Interferon-gamma -- genetics -- metabolism, Anthracenes -- pharmacology, Cysteine Proteinase Inhibitors -- pharmacology, Acetylcysteine -- analogs & derivatives -- pharmacology, Insulin-Secreting Cells -- cytology -- metabolism, JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors -- genetics -- metabolism, Nitric Oxide Donors -- pharmacology, Proteasome Inhibitors

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2101::5cd6bd8df62b7b298fb07b06ab18b32b
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/136991