المؤلفون: Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)

مصطلحات موضوعية: TG, thapsigargin, Cell signaling, ATF4, activating transcription factor 4, IKKβ, inhibitor of nuclear factor kappa-B kinase subunit beta, PERK, PKR-like ER kinase, XBP1, X-box-binding protein 1, OGTT, oral glucose tolerance test, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, GLuc, Gaussia luciferase, Chaperones, Protein biosynthesis, IL1β, interleukin 1β, General Pharmacology, Toxicology and Pharmaceutics, uHTS, ultra-high throughput screening, IRE1, inositol requiring enzyme 1α/β, 0303 health sciences, ASGR, asialoglycoprotein receptor 1, biology, Chemistry, Small molecules, Diabetes, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, ATF6, activating transcription factor 6α/β, β cells, i.p., intraperitoneal, Cell biology, Liver, 030220 oncology & carcinogenesis, T1/2D, type1/2 diabetes, Tm, tunicamycin, Protein folding, Original Article, ER stress, NASH, nonalcoholic steatohepatitis, INFγ, interferon gamma, TNFα, tumor necrosis factor alpha, RM1-950, GRPRP94, glucose-regulated protein 94, ER, endoplasmic reticulum, 03 medical and health sciences, SP1/2, serine protease1/2, GRP78, 78-kDa glucose-regulated protein, BID, twice a day, Pancreas, 030304 developmental biology, Reporter gene, Nod, non-obese diabetic, Activator (genetics), Endoplasmic reticulum, Metabolic diseases, Chaperone (protein), EGFP-VSVG, enhanced green fluorescence protein-vesicular stomatitis virus ts045 G protein, GSIS, glucose stimulated insulin secretion, biology.protein, Asialoglycoprotein receptor, Therapeutics. Pharmacology, CLuc, Cypridina luciferase, ERP72, endoplasmic reticulum proteins 72

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c176a631b2a5bf8251732009aad27d09
http://europepmc.org/articles/PMC8727761

المؤلفون: Mohsen Khosravi-Maharlooei, Rachel Madley, Chiara Borsotti, Leonardo M.R. Ferreira, Robert C. Sharp, Michael A. Brehm, Dale L. Greiner, Audrey V. Parent, Mark S. Anderson, Megan Sykes, Remi J. Creusot

المصدر: Molecular Metabolism

مصطلحات موضوعية: Physiology, Autoimmunity, Review, mTEC, medullary thymic epithelial cell, Mice, DC, dendritic cell, BCR, B cell receptor, Humanized mice, Insulin-Secreting Cells, 2.1 Biological and endogenous factors, Aetiology, PI, personalized immune, Pediatric, xGvHD, xenogeneic graft-versus-host disease, TCR, T cell receptor, Diabetes, T1D, Type 1 diabetes, RBC, red blood cell, In vitro models, SNP, single nucleotide polymorphism, HC, healthy control, MPS, microphysiological system, SP, single positive, Type 1 diabetes, Disease modeling, NOD, non-obese diabetic, NK, natural killer, Type 1, DP, double positive, iPSC, induced pluripotent stem cell, PBMC, peripheral blood mononuclear cell, Beta cell destruction, TOC, thymic organ culture, Treg, regulatory T cell, Autoimmune Disease, Clinical Research, HSC, hematopoietic stem cell, Diabetes Mellitus, Genetics, Animals, Humans, Molecular Biology, Metabolic and endocrine, HLA, human leukocyte antigen, Prevention, Inflammatory and immune system, Cell Biology, MHC, major histocompatibility, hPSC, human pluripotent stem cell, Diabetes Mellitus, Type 1, APC, antigen-presenting cell, Immune System, HIS, human immune system, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cbcfb9a236a8de465abdfc6194c120
https://doi.org/10.1016/j.molmet.2021.101417

المؤلفون: Kazuyuki Kasahara, Tzu Wen L. Cross, Federico E. Rey

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 15, Iss, Pp 70-81 (2018)

مصطلحات موضوعية: 0301 basic medicine, ER, estrogen receptor, FCG, four core genotypes, Metabolic disease, Physiology, Review, Disease, Type 2 diabetes, E2, estradiol, Gut flora, HDL-c, high-density lipoprotein cholesterol, SHP, small heterodimer partner, 0302 clinical medicine, GPR30, G protein-coupled receptor 30, Gonadal Steroid Hormones, Testosterone, ApoE, apolipoprotein E, Metabolic Syndrome, E3, estriol, Sex Characteristics, TMA, trimethylamine, High prevalence, IBD, inflammatory bowel disease, biology, LDL-c, low-density lipoprotein cholesterol, Cardiovascular disease, GI, gastrointestinal, E1, estrone, CVD, cardiovascular diseases, 3. Good health, Cardiovascular Diseases, Steroids, ZO-1, zonula occludens, T1D, type 1 diabetes, NOD, non-obese diabetic, MUC2, mucin-2, lcsh:Internal medicine, IBS, irritable bowel syndrome, T2D, type 2 diabetes, Gut microbiota, 03 medical and health sciences, FXR, farnesoid X receptor, TUDCA, tauroursodeoxycholic acid, Sex differences, medicine, Animals, Humans, lcsh:RC31-1245, Molecular Biology, Myocardium, BAs, bile acids, TLR4, Toll-like receptor 4, Cell Biology, medicine.disease, biology.organism_classification, Obesity, Gut microbiome, Gastrointestinal Microbiome, Sexual dimorphism, 030104 developmental biology, FMO3, flavin monooxygenases 3, LPS, lipopolysaccharides, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26b129281e97360a1e8ea4806d3c7e1
https://doi.org/10.1016/j.molmet.2018.05.016

المؤلفون: Per Olof Berggren, Shao-Nian Yang

المصدر: Pharmacology & Therapeutics

مصطلحات موضوعية: 0301 basic medicine, RIP, Rat insulin promoter, Biomedical Research, CFP, Cyan fluorescent protein, T2D, Type 2 diabetes, βFLUOMETRI, β Cell fluorescence metabolic transcriptional-response indicator, Rag2−/−, Recombination activating gene 2-deficient, Islets of Langerhans Transplantation, The anterior chamber of the eye, Teff, Effector T, 0302 clinical medicine, Diabetes mellitus, ob/+, Heterozygous for the obese spontaneous mutation, TCR-HA, T cell receptor α/β chains specific for the MHC Class II I-Ed-restricted determinant site 1 of HA, Pharmacology (medical), ACE, The anterior chamber of the eye, IEQ, Islet equivalent, geography.geographical_feature_category, SCID, Severe combined immunodeficiency mutation, T1D, Type 1 diabetes, Islet, DC, Dendritic cell, B6, C57BL/6, iPSC, Induced pluripotent stem cell, 3. Good health, medicine.anatomical_structure, HA, Influenza hemagglutinin, 030220 oncology & carcinogenesis, In vivo imaging, GFP, Green fluorescent protein, ob/ob, Homozygous for the obese spontaneous mutation, Preclinical imaging, Anterior Chamber, CaV, Voltage-gated Ca2+, Ad, Adenoviral, HSD, High sucrose diet, Context (language use), Article, [Ca2+]i, Cytosolic free calcium concentration, Pancreatic islet, NOD, Non-obese diabetic, 03 medical and health sciences, Insulin resistance, HFD, High fat diet, In vivo, HFrD, High fructose diet, medicine, Animals, Humans, ND, Normal diet, Pharmacology, MHC, Major histocompatibility complex, geography, business.industry, Pancreatic islets, MIP, Mouse insulin promoter, STZ, Streptozotocin, Tg, Transgenic, KATP, Adenosine triphosphate-sensitive K+, medicine.disease, Treg, Regulatory T, 030104 developmental biology, βIRB, β Cell insulin resistance biosensor, Autoimmune insulitis, business, Insulitis, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa0cc54977ee585479065e69678f400
https://pubmed.ncbi.nlm.nih.gov/30677477

المؤلفون: Patrick L. Green, Amanda R. Panfil, Jingyu Xiang, Said M. Elshafae, Aylin Alasonyalilar-Demirer, Wachirapan Supsahvad, Deborah J. Veis, Nicole A. Kohart, Katherine N. Weilbaecher, Thomas J. Rosol, Wessel P. Dirksen

المصدر: Journal of Bone Oncology
Journal of Bone Oncology, Vol 19, Iss, Pp-(2019)

مصطلحات موضوعية: ATL, adult T-cell leukemia/lymphoma, 0301 basic medicine, lcsh:Diseases of the musculoskeletal system, Osteolysis, Lymphoma, HHM, humoral hypercalcemia of malignancy, Bone resorption, lcsh:RC254-282, Jurkat cells, Mouse model, Metastasis, NSG, NOD-scid IL2Rgammanull, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Bone cell, medicine, Tax, transcriptional activator from the X region, business.industry, HTLV-1, Human T-cell leukemia virus type 1, Hbz, HTLV-1 basic zipper protein, μCT, micro-computed tomography, SCID, CB17-Prkdcscid, qRT-PCR, quantitative real-time polymerase chain reaction, Bone metastasis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 3. Good health, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, HTLV-1, 030220 oncology & carcinogenesis, Cancer research, Bone marrow, lcsh:RC925-935, NOD, non-obese diabetic, business, NK, natural killer, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dffdc06c9e78939eb20301f63a61de4
https://doi.org/10.1016/j.jbo.2019.100257

المؤلفون: Ana B. Ropero, Ester Sala, Joan Verdaguer, Upasana Sengupta, Belén Mezquita, Didac Mauricio, Angel Nadal, Laura Haba, Begoña Sánchez, Conchi Mora, Thomas Stratmann, Noemí Alejandra Saavedra-Ávila

المصدر: Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida

مصطلحات موضوعية: medicine.medical_specialty, ratón NOD (non obese diabetic), Cyclin D, Apoptosis, Nod, Biology, Diabetes Mellitus, Experimental, Islets of Langerhans, Mice, Mice, Inbred NOD, Internal medicine, medicine, Animals, Viability assay, Cyclin D3, NOD mice, Cyclin, Multidisciplinary, Pancreatic islets, autoimmunitat, Cell Cycle, Cell cycle, diabetis tipus 1, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, PNAS Plus, Autoantígens, Cancer research, biology.protein, Cytokines

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0803c6e61e3d50acfd0ac4c5b89a86e
https://hdl.handle.net/10459.1/48044

المؤلفون: Paolo Pozzilli, P. E. Beales, Roberto Liddi, Kenneth Batchelor, Alberto Signore, E. Procaccini, A. Giorgini

المصدر: European Journal of Pharmacology. 357:221-225

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Type 2 diabetes, Nitric oxide, Mice, Troglitazone, chemistry.chemical_compound, Mice, Inbred NOD, Diabetes mellitus, Internal medicine, medicine, Animals, Insulin, Chromans, Pancreas, Chromatography, High Pressure Liquid, NOD mice, Pharmacology, Type 1 diabetes, diabetes, type 1, nod (non-obese diabetic) mouse, troglitazone, business.industry, Age Factors, medicine.disease, Thiazoles, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Female, Thiazolidinediones, business, Insulitis, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d408975db0333fc4c4b518a8cc5e66
https://doi.org/10.1016/s0014-2999(98)00574-3

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المؤلفون: Stefano Cairo, John Bial, Matthew N. Svalina, Olivier Deas, Atiya Mansoor, Charles Keller, Elizabeth M. Wilson, Rishi Rikhi

المصدر: Biochemistry and Biophysics Reports

مصطلحات موضوعية: 0301 basic medicine, CA15-3, Oncology, medicine.medical_specialty, Hep Par 1, Hepatocyte Paraffin 1, medicine.medical_treatment, Population, Biophysics, Nod, Disease, DMEM, Dulbecco's Modified Eagle Medium, Biochemistry, HCM, Hepatocyte Culture Medium, IACUC, Institutional Animal Care and Use Committee, NOD, Non-obese diabetic, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Medicine, HER2, human epidermal growth factor receptor 2, education, AFP, Alpha Fetal Protein, skin and connective tissue diseases, Liver metastasis, Ad:uPA, Adenovirus Urokinase Plasminogen Activator, education.field_of_study, business.industry, Preclinical model, Cancer, pfu, plaque forming units, medicine.disease, GPC3, Glypican-3, 030104 developmental biology, Murine model, 030220 oncology & carcinogenesis, FRG™ KO, [ Fah(-/-) R ag2(-/-)Il2r g (-/-)]), business, Adjuvant, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c87b529c8b4e359022164dce6062eab