المؤلفون: Macaluso, M., Montanari, M., Noto, Pb, Gregorio, V., Surmacz, E., Antonio Giordano

المصدر: Università degli Studi di Siena-IRIS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bd0a02b790c4bd29f2941235eb381b32
http://hdl.handle.net/11365/34994

المؤلفون: Noto PB; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA. paul.x.noto@gsk.com., Sikorski TW; Protein Mass Spectrometry, In Vitro/In Vivo Translation, Research, GSK, Collegeville, USA., Zappacosta F; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA., Wagner CD; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA., Montes de Oca R; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA., Szapacs ME; Protein Mass Spectrometry, In Vitro/In Vivo Translation, Research, GSK, Collegeville, USA., Annan RS; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA., Liu Y; Epigenetics, Oncology R&D, GSK, Collegeville, USA., McHugh CF; Discovery DMPK, In Vitro / In Vivo Translation, Research, GSK, Collegeville, USA., Mohammad HP; Epigenetics, Oncology R&D, GSK, Collegeville, USA., Piccoli SP; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA.; Clinical Biomarkers and Diagnostics, Sun Pharmaceutical Advanced Research Center (SPARC), Princeton, USA., Creasy CL; Epigenetics, Oncology R&D, GSK, Collegeville, USA.

المصدر: Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22155. Date of Electronic Publication: 2020 Dec 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers*, Antineoplastic Agents/*pharmacokinetics , Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors , Repressor Proteins/*antagonists & inhibitors, Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents, Immunological/chemistry ; Antineoplastic Agents, Immunological/pharmacokinetics ; Antineoplastic Agents, Immunological/pharmacology ; Arginine/metabolism ; Cells, Cultured ; Chromatography, Liquid ; Drug Monitoring ; Enzyme Activation ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Heterogeneous Nuclear Ribonucleoprotein A1/blood ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Mass Spectrometry ; Methylation ; Mice ; Molecular Targeted Therapy ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Protein-Arginine N-Methyltransferases/genetics ; Repressor Proteins/genetics ; Substrate Specificity

المؤلفون: Tice CM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Noto PB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Fan KY; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Zhao W; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Lotesta SD; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Dong C; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Marcus AP; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Zheng YJ; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Chen G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Wu Z; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Van Orden R; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Zhou J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Bukhtiyarov Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Zhao Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Lipinski K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Howard L; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Guo J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Kandpal G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Meng S; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Hardy A; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Krosky P; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Gregg RE; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Leftheris K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., McKeever BM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Singh SB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Lala D; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., McGeehan GM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Zhuang L; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA., Claremon DA; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Oct 15; Vol. 26 (20), pp. 5044-5050. Date of Electronic Publication: 2016 Aug 29.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*metabolism , Liver X Receptors/*drug effects, ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Animals ; Male ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Up-Regulation

المؤلفون: Zheng Y; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Zhuang L; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Fan KY; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Tice CM; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Zhao W; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Dong C; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Lotesta SD; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Leftheris K; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Lindblom PR; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Liu Z; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Shimada J; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Noto PB; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Meng S; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Hardy A; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Howard L; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Krosky P; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Guo J; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Lipinski K; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Kandpal G; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Bukhtiyarov Y; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Zhao Y; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Lala D; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Van Orden R; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Zhou J; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Chen G; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Wu Z; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., McKeever BM; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., McGeehan GM; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Gregg RE; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Claremon DA; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Singh SB; Vitae Pharmaceuticals, Inc. , 502 W. Office Center Drive, Fort Washington, Pennsylvania 19034, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Apr 14; Vol. 59 (7), pp. 3264-71. Date of Electronic Publication: 2016 Mar 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Drug Discovery*, Benzylamines/*chemistry , Orphan Nuclear Receptors/*agonists , Piperazines/*chemistry , Pyrimidines/*chemistry , Pyrimidines/*metabolism , Sulfones/*chemistry , Sulfones/*metabolism, Binding Sites ; Crystallography, X-Ray ; Humans ; Liver X Receptors ; Structure-Activity Relationship

المؤلفون: Lotesta SD; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States. Electronic address: slotesta@vitaerx.com., Marcus AP; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Zheng Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Leftheris K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Noto PB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Meng S; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Kandpal G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Chen G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Zhou J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., McKeever B; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Bukhtiyarov Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Zhao Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Lala DS; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., Singh SB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States., McGeehan GM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Mar 15; Vol. 24 (6), pp. 1384-91. Date of Electronic Publication: 2016 Feb 09.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dibenzoxazepines/*pharmacology , Indoles/*pharmacology , Mineralocorticoid Receptor Antagonists/*pharmacology , Receptors, Mineralocorticoid/*metabolism , Spiro Compounds/*pharmacology, Crystallography, X-Ray ; Dibenzoxazepines/chemical synthesis ; Dibenzoxazepines/chemistry ; Dose-Response Relationship, Drug ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Mineralocorticoid Receptor Antagonists/chemical synthesis ; Mineralocorticoid Receptor Antagonists/chemistry ; Models, Molecular ; Molecular Structure ; Spiro Compounds/chemical synthesis ; Spiro Compounds/chemistry ; Structure-Activity Relationship

المؤلفون: Tice CM; Vitae Pharmaceuticals Inc. , 502 West Office Center Drive, Fort Washington, Pennsylvania 19034, United States., Noto PB, Fan KY, Zhuang L, Lala DS, Singh SB

المصدر: Journal of medicinal chemistry [J Med Chem] 2014 Sep 11; Vol. 57 (17), pp. 7182-205. Date of Electronic Publication: 2014 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anticholesteremic Agents/*chemistry , Anticholesteremic Agents/*therapeutic use , Atherosclerosis/*drug therapy , Orphan Nuclear Receptors/*agonists , Orphan Nuclear Receptors/*chemistry, Anticholesteremic Agents/metabolism ; Atherosclerosis/metabolism ; Benzoates/chemistry ; Benzoates/metabolism ; Benzoates/therapeutic use ; Benzylamines/chemistry ; Benzylamines/metabolism ; Benzylamines/therapeutic use ; Binding Sites ; Crystallography, X-Ray ; Humans ; Hydrocarbons, Fluorinated/chemistry ; Hydrocarbons, Fluorinated/metabolism ; Hydrocarbons, Fluorinated/therapeutic use ; Liver X Receptors ; Models, Molecular ; Molecular Structure ; Orphan Nuclear Receptors/metabolism ; Protein Isoforms/agonists ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Protein Structure, Tertiary ; Sulfonamides/chemistry ; Sulfonamides/metabolism ; Sulfonamides/therapeutic use

المؤلفون: Noto PB; Discovery Biology, Vitae Pharmaceuticals, Inc., Fort Washington, Pennsylvania, USA. pnoto@vitaerx.com, Bukhtiyarov Y, Shi M, McKeever BM, McGeehan GM, Lala DS

المصدر: Molecular pharmacology [Mol Pharmacol] 2012 Oct; Vol. 82 (4), pp. 719-27. Date of Electronic Publication: 2012 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Orphan Nuclear Receptors/*metabolism , Sphingomyelin Phosphodiesterase/*metabolism, Animals ; Benzoates/pharmacology ; Benzylamines/pharmacology ; Cell Line ; Gene Expression Regulation, Enzymologic ; Humans ; Liver X Receptors ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nicotinic Acids/pharmacology ; Orphan Nuclear Receptors/agonists ; Response Elements ; Retinoid X Receptors/agonists ; Reverse Transcriptase Polymerase Chain Reaction ; Species Specificity ; Sphingomyelin Phosphodiesterase/genetics ; Tetrahydronaphthalenes/pharmacology

المؤلفون: Noto PB; Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA., Abbadessa G, Cassone M, Mateo GD, Agelan A, Wade JD, Szabo D, Kocsis B, Nagy K, Rozgonyi F, Otvos L Jr

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2008 Jul; Vol. 17 (7), pp. 1249-55. Date of Electronic Publication: 2008 Apr 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*chemistry , Peptides/*chemistry , Proline/*chemistry, Animals ; Anti-Bacterial Agents/blood ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Chromatography, High Pressure Liquid ; Female ; In Vitro Techniques ; Mass Spectrometry ; Mice ; Microbial Sensitivity Tests ; Peptides/blood ; Peptides/pharmacokinetics ; Peptides/pharmacology

المؤلفون: Macaluso M; Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA. macaluso@temple.edu, Montanari M, Noto PB, Gregorio V, Bronner C, Giordano A

المصدر: Cancer research [Cancer Res] 2007 Aug 15; Vol. 67 (16), pp. 7731-7.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*genetics , Estrogen Receptor alpha/*genetics , Retinoblastoma Protein/*genetics, Azacitidine/analogs & derivatives ; Azacitidine/pharmacology ; Breast Neoplasms/enzymology ; Breast Neoplasms/metabolism ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Line, Tumor ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; Decitabine ; E1A-Associated p300 Protein/metabolism ; Estrogen Receptor alpha/metabolism ; Humans ; Promoter Regions, Genetic ; Retinoblastoma Protein/metabolism ; Retinoblastoma-Like Protein p107/metabolism ; Retinoblastoma-Like Protein p130/genetics ; Retinoblastoma-Like Protein p130/metabolism ; Ubiquitin-Protein Ligases

المؤلفون: Macaluso M; Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA., Montanari M, Noto PB, Gregorio V, Surmacz E, Giordano A

المصدر: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2006 Jun; Vol. 17 Suppl 7, pp. vii27-9.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*metabolism , Estrogen Receptor beta/*metabolism , Retinoblastoma-Like Protein p130/*metabolism, Amino Acid Sequence ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Humans ; Immunoprecipitation ; Molecular Sequence Data