يعرض 1 - 10 نتائج من 27 نتيجة بحث عن '"Nuria A Tamayo"', وقت الاستعلام: 1.17s تنقيح النتائج
  1. 1
    Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers

    المؤلفون: Brian Belmontes, Jodi Moriguchi, Grace Chung, Jan Sun, Maria Stefania S. Ninniri, Kelly Hanestad, Kui Chen, John D. McCarter, Upendra P. Dahal, Sudipa Ghimire-Rijal, Yue Hao, Christopher P. Mohr, Xinchao Yu, Matthew G. Rees, Melissa Ronan, Jennifer Roth, Sheroy Minocherhomji, Jennifer R. Allen, Matthew P. Bourbeau, Paul E. Hughes, Nuria A Tamayo, Marc N. Payton

    المصدر: Cancer Research. 83:516-516

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f35caf28e90cc86d95a85ee0af8c0a54
    https://doi.org/10.1158/1538-7445.am2023-516

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  2. 2
    Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

    المؤلفون: Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton

    المصدر: Journal of medicinal chemistry. 65(6)

    مصطلحات موضوعية: Cell Death, Tubulin, Neoplasms, Drug Discovery, Molecular Medicine, Humans, Kinesins, Mitosis, Spindle Apparatus

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b073c07dd2504a104516bc02d88ed4
    https://pubmed.ncbi.nlm.nih.gov/35286090

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  3. 3
    Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

    المؤلفون: Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee

    المصدر: Journal of Medicinal Chemistry. 63:52-65

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d131821132bab6ea5628a8639f9d9435
    https://doi.org/10.1021/acs.jmedchem.9b01180

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  4. 4
    Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

    المؤلفون: Heather Eastwood, Andrew Tasker, Yuping Chen, David Powers, Nadia Guerrero, Christopher Mohr, Anthony B. Reed, Jimmy Laszlo, Paul Wang, Yihong Zhou, Ryan Wurz, Mark H. Norman, Karen Rex, Jeffrey T. Winston, Liping H. Pettus, Dean Hickman, Yang Xu, Brian A. Lanman, Tian Wu, Yen Nguyen, Kristin L. Andrews, J. Russell Lipford, Frank Chavez, Hui-Ling Wang, Christine Sastri, Matthew R. Lee, Bethany Mattson, Nuria A. Tamayo, Victor J. Cee, Jie Chen, Bradley J. Herberich, Bin Wu, Shon Booker

    المصدر: Journal of Medicinal Chemistry. 59:6407-6430

    مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell, Administration, Oral, Antineoplastic Agents, Pharmacology, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Murine leukemia virus, medicine, Animals, Humans, Pyrroles, Kinase activity, Protein Kinase Inhibitors, Cell Proliferation, Quinazolinones, Dose-Response Relationship, Drug, Molecular Structure, biology, Cell growth, Chemistry, Drug discovery, Kinase, Neoplasms, Experimental, biology.organism_classification, Xenograft Model Antitumor Assays, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85b2099ac31a14dc5abf0c6c20c999
    https://doi.org/10.1021/acs.jmedchem.6b00610

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  5. 5
    Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

    المؤلفون: Kevin Yang, Rod Cupples, Gwyneth Van, Nobuko Nishimura, Longbin Liu, David J. St. Jean, Clarence Hale, Glenn Sivits, Jie Chen, Nuria A. Tamayo, Steven R. Jordan, Fang-Tsao Hong, Mark H. Norman, Michael D. Bartberger, Yunxin Bo, Christopher H. Fotsch, Samer Chmait, Seifu Tadesse, David Lloyd

    المصدر: Journal of Medicinal Chemistry. 58:4462-4482

    مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Conformation, Aminopyridines, Crystallography, X-Ray, Sulfone, Rats, Sprague-Dawley, Small Molecule Libraries, Structure-Activity Relationship, chemistry.chemical_compound, Glucokinase, Drug Discovery, Animals, Hypoglycemic Agents, Structure–activity relationship, Glucose homeostasis, Sulfones, Thiazole, Molecular Structure, Glucokinase regulatory protein, biology, Aryl, Small molecule, Rats, Glucose, Liver, chemistry, Biochemistry, biology.protein, Molecular Medicine, Carrier Proteins

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067ff276fb22038ac064d47a32d35c8
    https://doi.org/10.1021/jm5018175

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  6. 6
    Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

    المؤلفون: Bradley J. Herberich, Tian Wu, Paul E. Hughes, Claire L. M. Jackson, Nobuko Nishimura, Nancy Zhang, Ryan Wurz, Douglas A. Whittington, Shon Booker, Sean Caenepeel, Tisha San Miguel, Jian Jiang, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Brian A. Lanman, Andrew Tasker, Erin L. Mullady, John D. McCarter, Fang-Tsao Hong, Liping H. Pettus, Divesh Aidasani, Victor J. Cee, Ling Wang, Bin Wu, Mark H. Norman, Daniel J. Freeman, Kevin Yang, Longbin Liu, Leeanne Zalameda, Yunxin Y. Bo, Xiaochun Zhu, Kristin L. Andrews, Markian Stec, Nuria A. Tamayo, Raju Subramanian, Noel D'angelo

    المصدر: Journal of Medicinal Chemistry. 55:7796-7816

    مصطلحات موضوعية: Models, Molecular, Phosphoinositide 3-kinase, biology, Triazines, Chemistry, Cell growth, Pharmacology, Crystallography, X-Ray, medicine.disease, chemistry.chemical_compound, In vivo, Glioma, Drug Discovery, Second messenger system, medicine, biology.protein, Molecular Medicine, Phosphorylation, Phosphatidylinositol, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7379e5002efb24d810fb0e1f33a3641
    https://doi.org/10.1021/jm300846z

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  7. 7
    Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

    المؤلفون: Yunxin Y. Bo, Leeanne Zalameda, Kevin Yang, Fang-Tsao Hong, Longbin Liu, Anthony B. Reed, Kristin L. Andrews, Tisha San Miguel, Brian A. Lanman, Paul E. Hughes, Noel D'angelo, Brad Herberich, Jian Jiang, Victor J. Cee, Claire L. M. Jackson, Ryan Wurz, Nobuko Nishimura, Raju Subramanian, Seifu Tadesse, Nancy Zhang, John D. McCarter, Daniel J. Freeman, Ling Wang, Nuria A. Tamayo, Erin L. Mullady, Mark H. Norman, Liping H. Pettus, Tian Wu, Douglas A. Whittington, Sean Caenepeel, Adrian L. Smith, Shon Booker

    المصدر: Journal of Medicinal Chemistry. 55:5188-5219

    مصطلحات موضوعية: Models, Molecular, Indazoles, Class I Phosphatidylinositol 3-Kinases, Pyridines, Biological Availability, Mice, Nude, Crystallography, X-Ray, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Sulfones, Phosphatidylinositol, PI3K/AKT/mTOR pathway, Sulfonamides, Triazines, Akt/PKB signaling pathway, Chemistry, Kinase, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Rats, Cell biology, Pyrimidines, Biochemistry, Purines, Drug Design, Microsomes, Liver, Pyrazoles, Molecular Medicine, Female, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction, Phosphoinositide-dependent kinase-1

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e14c947647f0ff5c20164ffa4566dd
    https://doi.org/10.1021/jm300184s

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  8. 8
    Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

    المؤلفون: Sonya G. Lehto, Weiya Wang, Narender R. Gavva, Hong Deng, Mark H. Norman, Lana Klionsky, Nobuko Nishimura, Brad Youngblood, Phi Tang, Vu Van Ma, Jiyun Chen, Vijay Keshav Gore, Michael D. Bartberger, Nuria A. Tamayo, Tiffany L. Correll, Yunxin Bo

    المصدر: Journal of Medicinal Chemistry. 55:1593-1611

    مصطلحات موضوعية: Male, Administration, Oral, TRPM Cation Channels, CHO Cells, Pyrimidinones, In Vitro Techniques, Pharmacology, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Transient receptor potential channel, Cricetulus, Piperidines, In vivo, Oral administration, Cricetinae, Drug Discovery, TRPM8, Animals, Structure–activity relationship, Analgesics, Chemistry, Tetrahydroisoquinoline, Icilin, Antagonist, Stereoisomerism, Rats, Microsomes, Liver, Molecular Medicine, Calcium

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beaabfc08eed8ea8dfb711873a8ed34
    https://doi.org/10.1021/jm2013634

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  9. 9
    Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability

    المؤلفون: Kristin L. Andrews, Kevin Yang, Markian Stec, Tisha San Miguel, Ling Wang, John McCarter, Mark H. Norman, Shon Booker, Jian Jiang, Nan Zhang, Daniel J. Freeman, Erin L. Mullady, Hongyu Liao, Paul E. Hughes, Leeanne Zalameda, Sean Caenepeel, Raju Subramanian, Nuria A. Tamayo

    المصدر: Journal of Medicinal Chemistry. 54:5174-5184

    مصطلحات موضوعية: Models, Molecular, Pyridines, Metabolite, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Pharmacology, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Oxazoles, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Phosphoinositide 3-kinase, biology, Chemistry, TOR Serine-Threonine Kinases, Imidazoles, In vitro, Rats, Pyridazines, Thiazoles, medicine.anatomical_structure, Biochemistry, Benzothiazole, Acetylation, Hepatocyte, Hepatocytes, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a9feddc793ad895a56aaf047e435fd
    https://doi.org/10.1021/jm2004442

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  10. 10
    Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

    المؤلفون: Ling Wang, Leeanne Zalameda, Hongyu Liao, Kristin L. Andrews, Yunxin Bo, Nobuko Nishimura, Paul E. Hughes, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Douglas A. Whittington, Sean Caenepeel, Nancy Zhang, Daniel J. Freeman, Mark H. Norman, Shon Booker, Aaron C. Siegmund, Nuria A. Tamayo, Marian C. Bryan, Raju Subramanian, Kevin Yang, Longbin Liu

    المصدر: Journal of Medicinal Chemistry. 54:4735-4751

    مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Biological Availability, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, PI3K signaling, Rats, Sprague-Dawley, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Quinoxaline, In vivo, Quinoxalines, Drug Discovery, medicine, Animals, Humans, Phosphorylation, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Kinase, Chemistry, TOR Serine-Threonine Kinases, Quinoline, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Rats, Liver, Quinolines, Molecular Medicine, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51bb8cdaf63d264b7bb9e0cbc6de70
    https://doi.org/10.1021/jm200386s

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