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المؤلفون: Nim S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Corbi-Verge C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Perez-Riba A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Fujisawa K; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kapadia M; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Chau H; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Albanese F; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Pawar G; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., De Snoo ML; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ngana SG; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kim J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Rennella E; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Kay LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. suneil.kalia@utoronto.ca.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca., Kim PM; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.; Department of Computer Science, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.

المصدر: Nature communications [Nat Commun] 2023 Apr 19; Vol. 14 (1), pp. 2150. Date of Electronic Publication: 2023 Apr 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism, Male ; Female ; Animals ; Rats ; Humans ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Caenorhabditis elegans/metabolism ; Dopaminergic Neurons/metabolism ; Endosomal Sorting Complexes Required for Transport/metabolism ; Peptides/pharmacology ; Peptides/metabolism

المؤلفون: Hayes JM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., O'Hara DM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Davey GP; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. gdavey@tcd.ie.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2370, pp. 315-322.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Carbohydrates* , Click Chemistry* , Neurons*/chemistry, Animals ; Glycosylation ; Polysaccharides ; Rats

المؤلفون: Chen KS; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Menezes K; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Rodgers JB; Donnelly Centre, University of Toronto, Toronto, ON, Canada., O'Hara DM; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Tran N; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Fujisawa K; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ishikura S; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Khodaei S; Donnelly Centre, University of Toronto, Toronto, ON, Canada., Chau H; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Cranston A; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kapadia M; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Pawar G; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ping S; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Krizus A; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Lacoste A; BenevolentAI, New York, NY, USA., Spangler S; IBM Research-Almaden, San Jose, CA, USA., Visanji NP; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Marras C; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Majbour NK; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Lozano AM; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada., Culotti J; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Suo S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Pharmacology, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Ryu WS; Donnelly Centre, University of Toronto, Toronto, ON, Canada.; Department of Physics, University of Toronto, Toronto, ON, Canada., Kalia SK; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.; KITE and CRANIA, University Health Network, Toronto, ON, Canada., Kalia LV; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.

المصدر: Molecular neurodegeneration [Mol Neurodegener] 2021 Nov 12; Vol. 16 (1), pp. 77. Date of Electronic Publication: 2021 Nov 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE

مواضيع طبية MeSH: Motor Disorders*/metabolism , alpha-Synuclein*/metabolism, Animals ; Artificial Intelligence ; Caenorhabditis elegans/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Mammals/metabolism ; Rats

المؤلفون: O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto; darren.ohara@uhnresearch.ca., Kapadia M; Krembil Research Institute, Toronto Western Hospital, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto., Ping S; Krembil Research Institute, Toronto Western Hospital, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto; Department of Surgery, Division of Neurosurgery, University of Toronto., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto; Department of Medicine, Division of Neurology, University of Toronto; Department of Medicine, Division of Neurology, Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 02 (168). Date of Electronic Publication: 2021 Feb 02.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Dopaminergic Neurons/*cytology , Image Processing, Computer-Assisted/*methods , Immunohistochemistry/*methods , Substantia Nigra/*cytology , Tyrosine 3-Monooxygenase/*metabolism , alpha-Synuclein/*metabolism, Animals ; Dopaminergic Neurons/metabolism ; Female ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra/metabolism

المؤلفون: Friesen EL; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Zhang YT; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Earnshaw R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., De Snoo ML; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., O'Hara DM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Agapova V; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Chau H; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Ngana S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Chen KS; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada., Kalia LV; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Kalia SK; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Aug 04; Vol. 8, pp. 716. Date of Electronic Publication: 2020 Aug 04 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE

المؤلفون: O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Canada., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Canada.; Department of Medicine, Division of Neurology, Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.

المصدر: Critical reviews in clinical laboratory sciences [Crit Rev Clin Lab Sci] 2020 Aug; Vol. 57 (5), pp. 291-307. Date of Electronic Publication: 2020 Mar 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8914816 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-781X (Electronic) Linking ISSN: 10408363 NLM ISO Abbreviation: Crit Rev Clin Lab Sci Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease/*metabolism , alpha-Synuclein/*analysis, Animals ; Biomarkers/blood ; Brain/metabolism ; Brain/pathology ; Humans ; Lewy Bodies/metabolism ; Lewy Bodies/pathology ; Parkinson Disease/diagnosis ; Parkinson Disease/pathology ; Phosphorylation ; Protein Aggregation, Pathological/metabolism ; alpha-Synuclein/metabolism

المؤلفون: O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Pawar G; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.

المصدر: Frontiers in neuroscience [Front Neurosci] 2020 Jun 17; Vol. 14, pp. 577. Date of Electronic Publication: 2020 Jun 17 (Print Publication: 2020).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE

المؤلفون: McKinnon C; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., De Snoo ML; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Gondard E; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Neudorfer C; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Chau H; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Ngana SG; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Brotchie JM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Koprich JB; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Lozano AM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.; Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada. suneil.kalia@utoronto.ca.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca.

المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Feb 14; Vol. 8 (1), pp. 17. Date of Electronic Publication: 2020 Feb 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Dopaminergic Neurons/*metabolism , Pars Compacta/*metabolism , Proteasome Endopeptidase Complex/*metabolism , Ubiquitin/*metabolism , alpha-Synuclein/*metabolism, Animals ; Female ; HEK293 Cells ; Humans ; Rats, Sprague-Dawley

المؤلفون: Patrick PA; Westchester Institute for Human Development, Valhalla, NY, USA; School of Health Sciences & Practices, New York Medical College, Valhalla, NY, USA; Department of Pediatrics, New York Medical College, Valhalla, NY, USA. Electronic address: ppatrick@wihd.org., Obermeyer I; Westchester Institute for Human Development, Valhalla, NY, USA; School of Health Sciences & Practices, New York Medical College, Valhalla, NY, USA., Xenakis J; Westchester Institute for Human Development, Valhalla, NY, USA; School of Health Sciences & Practices, New York Medical College, Valhalla, NY, USA., Crocitto D; Westchester Institute for Human Development, Valhalla, NY, USA., O'Hara DM; Westchester Institute for Human Development, Valhalla, NY, USA; School of Health Sciences & Practices, New York Medical College, Valhalla, NY, USA.

المصدر: Disability and health journal [Disabil Health J] 2020 Jan; Vol. 13 (1), pp. 100840. Date of Electronic Publication: 2019 Sep 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101306633 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7583 (Electronic) Linking ISSN: 18767583 NLM ISO Abbreviation: Disabil Health J Subsets: MEDLINE

مواضيع طبية MeSH: Computers/*statistics & numerical data , Developmental Disabilities/*rehabilitation , Intellectual Disability/*rehabilitation , Self-Help Devices/*statistics & numerical data , Social Media/*statistics & numerical data, Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Disabled Persons/statistics & numerical data ; Female ; Health Services Accessibility/statistics & numerical data ; Humans ; Male ; Middle Aged ; New York ; Personal Autonomy ; Smartphone/statistics & numerical data ; Surveys and Questionnaires ; Young Adult