المؤلفون: Kundert, K, Lucas, JE, Watters, KE, Fellmann, C, Ng, AH, Heineike, BM, Fitzsimmons, CM, Oakes, BL, Qu, J, Prasad, N, Rosenberg, OS, Savage, DF, El-Samad, H, Doudna, JA, Kortemme, T

المصدر: Nature communications. 10(1)

مصطلحات موضوعية: DNA, RNA, Guide, Ligands, Aptamers, Nucleotide, CRISPR-Cas Systems, Gene Editing, CRISPR-Associated Protein 9, Biochemistry and Cell Biology, Physical Sciences, Biological Sciences, Biotechnology, Genetics, Generic health relevance, RNA, Guide, Kinetoplastida

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3t52t2n5

المؤلفون: Oostveen RF; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, The Netherlands (R.F.O., E.S.G.S., J.J.P.K.)., Khera AV; Verve Therapeutics, Boston, MA (A.V.K., S.K.)., Kathiresan S; Verve Therapeutics, Boston, MA (A.V.K., S.K.)., Stroes ESG; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, The Netherlands (R.F.O., E.S.G.S., J.J.P.K.)., Fitzgerald K; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, The Netherlands (R.F.O., E.S.G.S., J.J.P.K.)., Harms MJ; Scribe Therapeutics, Alameda, CA (M.J.H., B.L.O.)., Oakes BL; Scribe Therapeutics, Alameda, CA (M.J.H., B.L.O.)., Kastelein JJP; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, The Netherlands (R.F.O., E.S.G.S., J.J.P.K.).

المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2023 Jul; Vol. 43 (7), pp. 1081-1092. Date of Electronic Publication: 2023 Jun 01.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Proprotein Convertase 9*/genetics , Gene Editing*, Humans ; Cholesterol, LDL ; RNA, Small Interfering/genetics

المؤلفون: Shams A; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA., Higgins SA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Scribe Therapeutics, Alameda, CA, 94501, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA., Laughlin TG; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Division of Biological Sciences, University of California, San Diego, San Diego, CA, 92093, USA., Oakes BL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Scribe Therapeutics, Alameda, CA, 94501, USA., Lew R; Gladstone Institutes, San Francisco, CA, 94158, USA., Kim S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA., Lukarska M; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA., Arnold M; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA., Staahl BT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Scribe Therapeutics, Alameda, CA, 94501, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Gladstone Institutes, San Francisco, CA, 94158, USA.; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, CA, 94720, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, 94720, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA. savage@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, 94720, USA. savage@berkeley.edu.

المصدر: Nature communications [Nat Commun] 2021 Sep 27; Vol. 12 (1), pp. 5664. Date of Electronic Publication: 2021 Sep 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Associated Protein 9/*genetics , CRISPR-Cas Systems/*genetics , Protein Interaction Domains and Motifs/*genetics , RNA, Guide, CRISPR-Cas Systems/*metabolism, CRISPR-Associated Protein 9/metabolism ; CRISPR-Associated Protein 9/ultrastructure ; Cell Line, Tumor ; Cryoelectron Microscopy ; DNA/metabolism ; Gene Editing/methods ; Humans ; Single Molecule Imaging

المؤلفون: An-Adirekkun JM; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin., Stewart CJ; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin., Geller SH; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin., Patel MT; Lewis-Sigler Institute for Integrated Genomics, Princeton University, Princeton, New Jersey., Melendez J; Lewis-Sigler Institute for Integrated Genomics, Princeton University, Princeton, New Jersey., Oakes BL; Lewis-Sigler Institute for Integrated Genomics, Princeton University, Princeton, New Jersey., Noyes MB; Department of Biochemistry and Molecular Pharmacology and Institute for Systems Genetics, NYU Langone Health, New York, New York., McClean MN; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.

المصدر: Biotechnology and bioengineering [Biotechnol Bioeng] 2020 Mar; Vol. 117 (3), pp. 886-893. Date of Electronic Publication: 2019 Dec 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Fungal*/genetics , Gene Expression Regulation, Fungal*/radiation effects , Promoter Regions, Genetic*/genetics, Optogenetics/*methods , Saccharomyces cerevisiae/*genetics, Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cloning, Molecular ; Cryptochromes/genetics ; Cryptochromes/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Zinc Fingers/genetics

المؤلفون: Huang TP; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Zhao KT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Miller SM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Gaudelli NM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Oakes BL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.

المصدر: Nature biotechnology [Nat Biotechnol] 2019 Jul; Vol. 37 (7), pp. 820.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: PubMed not MEDLINE

المؤلفون: Huang TP; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Zhao KT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Miller SM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Gaudelli NM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Oakes BL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.

المصدر: Nature biotechnology [Nat Biotechnol] 2019 Jun; Vol. 37 (6), pp. 626-631. Date of Electronic Publication: 2019 May 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Associated Protein 9/*genetics , CRISPR-Cas Systems/*genetics , Gene Editing/*methods, Adenine/chemistry ; Cytosine/chemistry ; Humans ; Nucleotides/chemistry ; Nucleotides/genetics ; Plasmids/chemistry ; Plasmids/genetics

المؤلفون: Liu JJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Orlova N; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA., Oakes BL; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Ma E; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Spinner HB; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Baney KLM; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Chuck J; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Tan D; Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA., Knott GJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Harrington LB; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Al-Shayeb B; Department of Plant and Microbiology, University of California, Berkeley, CA, USA., Wagner A; Max-Planck-Institute for Biochemistry, Planegg, Germany., Brötzmann J; Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Staahl BT; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Taylor KL; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Desmarais J; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Nogales E; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. enogales@lbl.gov.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA. enogales@lbl.gov.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. enogales@lbl.gov.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. enogales@lbl.gov., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Gladstone Institutes, San Francisco, CA, USA. doudna@berkeley.edu.

المصدر: Nature [Nature] 2019 Apr; Vol. 568 (7752), pp. E8-E10.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE

المؤلفون: Liu JJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Orlova N; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA., Oakes BL; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Ma E; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Spinner HB; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Baney KLM; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Chuck J; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Tan D; Clayton Foundation Laboratories of Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA., Knott GJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Harrington LB; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Al-Shayeb B; Department of Plant and Microbiology, University of California, Berkeley, CA, USA., Wagner A; Max-Planck-Institute for Biochemistry, Planegg, Germany., Brötzmann J; Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Staahl BT; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Taylor KL; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Desmarais J; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Nogales E; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. enogales@lbl.gov.; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA. enogales@lbl.gov.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. enogales@lbl.gov.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. enogales@lbl.gov., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Gladstone Institutes, San Francisco, CA, USA. doudna@berkeley.edu.

المصدر: Nature [Nature] 2019 Feb; Vol. 566 (7743), pp. 218-223. Date of Electronic Publication: 2019 Feb 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature

مواضيع طبية MeSH: Gene Editing*, CRISPR-Associated Proteins/*classification , CRISPR-Associated Proteins/*ultrastructure , CRISPR-Cas Systems/*genetics, CRISPR-Associated Proteins/chemistry ; CRISPR-Associated Proteins/metabolism ; Cryoelectron Microscopy ; DNA/chemistry ; DNA/metabolism ; DNA/ultrastructure ; DNA Cleavage ; Escherichia coli/genetics ; Evolution, Molecular ; Gene Silencing ; Genome, Bacterial/genetics ; Genome, Human/genetics ; Humans ; Models, Molecular ; Nucleic Acid Conformation ; Protein Domains ; RNA, Guide, CRISPR-Cas Systems/metabolism

المؤلفون: Oakes BL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Gladstone Institutes, San Francisco, CA 94158, USA., Rishi H; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, CA 94720, USA., Taylor KL; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Ren SM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Nadler DC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Yokoo R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Arkin AP; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Graduate Group in Biophysics, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: savage@berkeley.edu.

المصدر: Cell [Cell] 2019 Jan 10; Vol. 176 (1-2), pp. 254-267.e16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems/*physiology , Clustered Regularly Interspaced Short Palindromic Repeats/*physiology , Gene Editing/*methods, CRISPR-Associated Proteins/chemistry ; DNA/chemistry ; Genome ; Models, Molecular ; RNA/chemistry ; RNA, Guide, CRISPR-Cas Systems/genetics

المؤلفون: Oakes BL; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Nadler DC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Flamholz A; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Staahl BT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, USA.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, California, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, California, USA.; Energy Biosciences Institute, University of California, Berkeley, Berkeley, California, USA.

المصدر: Nature biotechnology [Nat Biotechnol] 2016 Jun; Vol. 34 (6), pp. 646-51. Date of Electronic Publication: 2016 May 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*genetics , Clustered Regularly Interspaced Short Palindromic Repeats/*genetics , Endonucleases/*genetics , Genes, Switch/*genetics , Mutagenesis, Insertional/*genetics , Mutagenesis, Insertional/*methods , Protein Engineering/*methods, Allosteric Regulation/genetics ; Binding Sites ; CRISPR-Associated Protein 9 ; Mutagenesis, Site-Directed/methods ; Protein Binding ; Protein Domains