المؤلفون: Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Son J; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Okoro JJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Mira A; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy., Patrucco E; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy., Eum Y; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Wang X; Harvard Graduate School of Arts and Sciences, Harvard University, Cambridge, Massachusetts.; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Paranal R; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Wang H; School of Life Sciences and Technology, Tongji University, Shanghai, China., Lin M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Haikala HM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Li J; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Xu Y; School of Life Sciences and Technology, Tongji University, Shanghai, China., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Chhoeu C; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Redig AJ; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Köhler J; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Dholakia KH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Chen Y; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Richard E; Institut Bergonié, INSERM U1218, ACTION Laboratory, Bordeaux, France., Nokin MJ; University of Bordeaux, INSERM U1218, ACTION Laboratory, IECB, Pessac, France., Santamaria D; University of Bordeaux, INSERM U1218, ACTION Laboratory, IECB, Pessac, France., Gokhale PC; Experimental Therapeutics Core and Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Ambrogio C; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Apr 14; Vol. 28 (8), pp. 1640-1650.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology, Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; Mitogen-Activated Protein Kinase Kinases/genetics ; Mutation ; NF-E2-Related Factor 2/genetics ; Protein Isoforms/genetics ; Proto-Oncogene Proteins p21(ras)/genetics

المؤلفون: Mysore VP; D. E. Shaw Research, New York, NY, USA., Zhou ZW; Departments of Biochemistry and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ambrogio C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin, Italy., Li L; Departments of Biochemistry and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kapp JN; Department of Biochemistry, University of Zürich, Zürich, Switzerland., Lu C; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang Q; D. E. Shaw Research, New York, NY, USA., Tucker MR; D. E. Shaw Research, New York, NY, USA., Okoro JJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nagy-Davidescu G; Department of Biochemistry, University of Zürich, Zürich, Switzerland., Bai X; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Plückthun A; Department of Biochemistry, University of Zürich, Zürich, Switzerland., Jänne PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Westover KD; Departments of Biochemistry and Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Shan Y; D. E. Shaw Research, New York, NY, USA. Yibing.Shan@DEShawResearch.com., Shaw DE; D. E. Shaw Research, New York, NY, USA. David.Shaw@DEShawResearch.com.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. David.Shaw@DEShawResearch.com.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Oct; Vol. 28 (10), pp. 847-857. Date of Electronic Publication: 2021 Oct 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Proto-Oncogene Proteins c-raf/*chemistry , Proto-Oncogene Proteins c-raf/*metabolism , Proto-Oncogene Proteins p21(ras)/*chemistry , Proto-Oncogene Proteins p21(ras)/*metabolism, Blood Proteins/chemistry ; Blood Proteins/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Fluorescence Resonance Energy Transfer ; GTPase-Activating Proteins/chemistry ; GTPase-Activating Proteins/metabolism ; Galectins/chemistry ; Galectins/metabolism ; Guanosine Triphosphate/chemistry ; Guanosine Triphosphate/metabolism ; HEK293 Cells ; Humans ; MAP Kinase Kinase 1/metabolism ; Microscopy, Electron ; Microscopy, Electron, Transmission ; Molecular Dynamics Simulation ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/metabolism ; Mutagenesis ; Protein Multimerization ; Proto-Oncogene Proteins c-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Reproducibility of Results ; Signal Transduction ; Transcription Factors/chemistry ; Transcription Factors/metabolism

المؤلفون: Eser PÖ; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Paranal RM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Son J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Ivanova E; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Kuang Y; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Haikala HM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., To C; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Okoro JJ; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Dholakia KH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Choi J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Eum Y; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ogino A; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Missios P; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA., Ercan D; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Xu M; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Poitras MJ; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wang S; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ngo K; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Dills M; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Yanagita M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lopez T; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Lin M; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tsai J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Floch N; Oncology R&D, Bioscience, AstraZeneca, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK., Chambers ES; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Heng J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Anjum R; Bioscience, Oncology R&D, AstraZeneca, 25 Gatehouse Park, Waltham, MA 02451, USA., Santucci AD; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Michael K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Schuller AG; Bioscience, Oncology R&D, AstraZeneca, 25 Gatehouse Park, Waltham, MA 02451, USA., Cross D; Global Medical Affairs, Oncology Business Unit, AstraZeneca, 136 Hills Road, Cambridge CB2 8PA, UK., Smith PD; Oncology R&D, Bioscience, AstraZeneca, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK., Oxnard GR; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Barbie DA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Sholl LM; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Bahcall M; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA., Palakurthi S; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Gokhale PC; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Paweletz CP; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Daley GQ; Harvard Medical School, Boston, MA 02115, USA.; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

المصدر: Science translational medicine [Sci Transl Med] 2021 Sep; Vol. 13 (609), pp. eabb3738. Date of Electronic Publication: 2021 Sep 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics, Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; Humans ; Mutation/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Zhou ZW; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas., Ambrogio C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino, Torino, Italy., Bera AK; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas., Li Q; Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China., Li XX; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas., Li L; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas., Son J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gondi S; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas., Li J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Campbell E; Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah., Jin H; Department of Thoracic Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China., Okoro JJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Xu CX; Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China. kenneth.westover@utsouthwestern.edu pasi_janne@dfci.harvard.edu xuchengxiong@hanmail.net., Janne PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. kenneth.westover@utsouthwestern.edu pasi_janne@dfci.harvard.edu xuchengxiong@hanmail.net.; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Westover KD; Departments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas. kenneth.westover@utsouthwestern.edu pasi_janne@dfci.harvard.edu xuchengxiong@hanmail.net.

المصدر: Cancer research [Cancer Res] 2020 Sep 01; Vol. 80 (17), pp. 3719-3731. Date of Electronic Publication: 2020 Jun 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung/*genetics , Lung Neoplasms/*genetics , MAP Kinase Signaling System/*physiology , Proto-Oncogene Proteins p21(ras)/*genetics , raf Kinases/*genetics, Animals ; Carcinoma, Non-Small-Cell Lung/metabolism ; Female ; HEK293 Cells ; Heterografts ; Humans ; Lung Neoplasms/metabolism ; Mice ; Mutation ; Proto-Oncogene Proteins p21(ras)/chemistry ; Proto-Oncogene Proteins p21(ras)/metabolism