المؤلفون: Bettegowda, C, Sausen, M, Leary, RJ, Kinde, I, Wang, YX, Agrawal, N, Bartlett, BR, Wang, H, Luber, B, Alani, RM, Antonarakis, ES, Azad, NS, Bardelli, A, Brem, H, Cameron, JL, Lee, CC, Fecher, LA, Gallia, GL, Gibbs, P, Le, D, Giuntoli, RL, Goggins, M, Hogarty, MD, Holdhoff, M, Hong, SM, Jiao, YC, Juhl, HH, Kim, JJ, Siravegna, G, Laheru, DA, Lauricella, C, Lim, M, Lipson, EJ, Marie, SKN, Netto, GJ, Oliner, KS, Olivi, A, Olsson, L, Riggins, GJ, Sartore-Bianchi, A, Schmidt, K, Shih, IM, Oba-Shinjo, SM, Siena, S, Theodorescu, D, Tie, JN, Harkins, TT, Veronese, S, Wang, TL, Weingart, JD, Wolfgang, CL, Wood, LD, Xing, DM, Hruban, RH, Wu, J, Allen, PJ, Schmidt, CM, Choti, MA, Velculescu, VE, Kinzler, KW, Vogelstein, B, Papadopoulos, N, Luis, AJ

المصدر: Science translational medicine. 6(224)

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:128408322

المؤلفون: Karthaus M; Klinikum Neuperlach/Klinikum Harlaching, Oskar-Maria-Graf-Ring 51, D81737 Munich, Germany., Hofheinz RD; Universitätsmedizin Mannheim, Theodor-Kutzer Ufer 1-3, 68167 Mannheim, Germany., Mineur L; Institut Sainte-Catherine GI and Liver Cancer Unit, 84 000 Avignon, France., Letocha H; Oncology Clinic, Västmanland's Hospital, 721 89 Västerås, Sweden., Greil R; IIIrd Medical Department, Paracelsus Medical University Salzburg and CCCIT Salzburg Cancer Research Institute, Müllner Hauptstrasse 45, 5020 Salzburg, Austria., Thaler J; Klinikum Wels-Grieskirchen, Grieskirchner Straße 42, A-4600 Wels, Austria., Fernebro E; Central Hospital, Strandvägen 8, 35185 Växjö, Sweden., Oliner KS; Formerly of Amgen Inc., 1 Amgen Center Dr MS 30E-2-C, Thousand Oaks, CA 91320, USA., Boedigheimer M; Amgen Inc., 1 Amgen Center Dr MS 30E-2-C, Thousand Oaks, CA 91320, USA., Twomey B; Amgen Inc., 1 Amgen Center Dr MS 30E-2-C, Thousand Oaks, CA 91320, USA., Zhang Y; Amgen Inc., 1 Amgen Center Dr MS 30E-2-C, Thousand Oaks, CA 91320, USA., Demonty G; Amgen GmbH, Dammstrasse 23, 6301 Zug, Switzerland., Köhne CH; Onkologie Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133 Oldenburg, Germany.

المصدر: British journal of cancer [Br J Cancer] 2016 Nov 08; Vol. 115 (10), pp. 1215-1222. Date of Electronic Publication: 2016 Oct 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Colorectal Neoplasms/*drug therapy , Colorectal Neoplasms/*genetics , Proto-Oncogene Proteins B-raf/*genetics , ras Proteins/*genetics, Amphiregulin/genetics ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Biomarkers, Tumor/metabolism ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Clinical Trials, Phase II as Topic ; Disease-Free Survival ; Fluorouracil/administration & dosage ; Humans ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Panitumumab ; Proportional Hazards Models ; Retrospective Studies

SCR Protocol: IFL protocol

المؤلفون: Wirth LJ; Massachusetts General Hospital, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: lwirth@mgh.harvard.edu., Dakhil S; Cancer Center of Kansas, Wichita, KS, USA., Kornek G; Medizinische Universitaet Wien, Wien, Austria., Axelrod R; Thomas Jefferson University Hospital, Philadelphia, PA, USA., Adkins D; Washington University School of Medicine, St. Louis, MO, USA., Pant S; University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., O'Brien P; Medical University of South Carolina, Charleston, SC, USA., Debruyne PR; Kortrijk Cancer Centre, General Hospital Groeninge, Kortrijk, Belgium; Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK., Oliner KS; Amgen Inc., Thousand Oaks, CA, USA., Dong J; Amgen Inc., Thousand Oaks, CA, USA., Murugappan S; Amgen Inc., Thousand Oaks, CA, USA.

المصدر: Oral oncology [Oral Oncol] 2016 Oct; Vol. 61, pp. 31-40. Date of Electronic Publication: 2016 Aug 20.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0593 (Electronic) Linking ISSN: 13688375 NLM ISO Abbreviation: Oral Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Carcinoma, Squamous Cell/*drug therapy , Head and Neck Neoplasms/*drug therapy, Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Carcinoma, Squamous Cell/pathology ; Cisplatin/administration & dosage ; Docetaxel ; Female ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Panitumumab ; Squamous Cell Carcinoma of Head and Neck ; Taxoids/administration & dosage

المؤلفون: Erichsen R; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark. Electronic address: re@clin.au.dk., Kelsh MA; Center for Observational Research, Amgen Inc., Thousand Oaks, CA., Oliner KS; Medical Sciences, Amgen Inc., Thousand Oaks, CA., Nielsen KB; Dako Denmark A/S, Glostrup, Denmark., Frøslev T; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark., Lænkholm AV; Department of Pathology, Slagelse Hospital, Slagelse, Denmark., Vyberg M; Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark., Acquavella J; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark; Center for Observational Research, Amgen Inc., Thousand Oaks, CA., Sørensen HT; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.

المصدر: Annals of epidemiology [Ann Epidemiol] 2016 Jul; Vol. 26 (7), pp. 500-503. Date of Electronic Publication: 2016 May 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9100013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2585 (Electronic) Linking ISSN: 10472797 NLM ISO Abbreviation: Ann Epidemiol Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*metabolism , Adenocarcinoma/*mortality , Biomarkers, Tumor/*metabolism , Proto-Oncogene Proteins c-met/*metabolism , Stomach Neoplasms/*metabolism , Stomach Neoplasms/*mortality, Adenocarcinoma/pathology ; Adult ; Aged ; Cohort Studies ; Confidence Intervals ; Databases, Factual ; Denmark ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Mas ; Retrospective Studies ; Risk Assessment ; Stomach Neoplasms/pathology ; Survival Analysis

المؤلفون: Peeters M; Antwerp University Hospital and University of Antwerp, Edegem, Belgium. Marc.Peeters@uza.be., Oliner KS; Amgen Inc., Thousand Oaks, California, USA., Price TJ; Queen Elizabeth Hospital and University of Adelaide, Woodville, Australia., Cervantes A; Biomedical Research Institute INCLIVA, University of Valencia, Spain., Sobrero AF; Ospedale San Martino, Genova, Italy., Ducreux M; Institut Gustave Roussy, Villejuif, and Paris-Sud University, Le Kremlin Bicêtre, Paris, France., Hotko Y; Uzhgorod National University, Uzhgorod, Ukraine., André T; Hôpital Saint Antoine and Université Pierre et Marie Curie (UMPC; Paris VI), Paris, France., Chan E; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lordick F; University Cancer Center, Leipzig, Germany., Punt CJ; Academic Medical Center, Amsterdam, the Netherlands., Strickland AH; Monash Medical Center, East Bentleigh, Australia., Wilson G; Christie Hospital, Manchester, United Kingdom., Ciuleanu TE; Institutul Oncologic Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania., Roman L; Leningrad Regional Oncology Dispensary, Saint Petersburg, Russia., Van Cutsem E; University Hospitals and KU Leuven, Leuven, Belgium., He P; Amgen Inc., Thousand Oaks, California, USA., Yu H; Amgen Inc., Thousand Oaks, California, USA., Koukakis R; Amgen (Europe) GmbH, Zug, Switzerland., Terwey JH; Amgen (Europe) GmbH, Zug, Switzerland., Jung AS; Amgen Inc., Thousand Oaks, California, USA., Sidhu R; Amgen Inc., Thousand Oaks, California, USA., Patterson SD; Amgen Inc., Thousand Oaks, California, USA.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2015 Dec 15; Vol. 21 (24), pp. 5469-79. Date of Electronic Publication: 2015 Sep 04.

نوع المنشور: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Genes, ras* , Mutation*, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Camptothecin/*analogs & derivatives , Colorectal Neoplasms/*drug therapy , Colorectal Neoplasms/*genetics, Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Camptothecin/adverse effects ; Camptothecin/therapeutic use ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; DNA Mutational Analysis ; Exons ; Female ; Fluorouracil/adverse effects ; Fluorouracil/therapeutic use ; Humans ; Leucovorin/adverse effects ; Leucovorin/therapeutic use ; Male ; Middle Aged ; Neoplasm Metastasis ; Panitumumab ; Proportional Hazards Models ; Proto-Oncogene Proteins B-raf/genetics ; Retreatment ; Survival Analysis ; Treatment Outcome

SCR Protocol: IFL protocol

المؤلفون: Peng Z; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China., Li Z; Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China., Gao J; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China., Lu M; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China., Gong J; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China., Tang ET; Biostatistical Science, Amgen Inc., Shanghai, China., Oliner KS; Molecular Sciences, Amgen Inc., Thousand Oaks, California., Hei YJ; Global Development, Amgen Inc., Shanghai, China., Zhou H; Medical Department, Amgen Inc., Shanghai, China., Shen L; Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China. lin100@medmail.com.cn.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2015 Nov; Vol. 14 (11), pp. 2634-41. Date of Electronic Publication: 2015 Sep 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Gene Amplification*, Esophagogastric Junction/*metabolism , Proto-Oncogene Proteins c-met/*genetics , Stomach Neoplasms/*genetics, Asian People/genetics ; China ; Drug Therapy/methods ; Esophagogastric Junction/drug effects ; Esophagogastric Junction/pathology ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Neoplasm Metastasis ; Phosphorylation ; Prognosis ; Proto-Oncogene Proteins c-met/metabolism ; Stomach Neoplasms/ethnology ; Stomach Neoplasms/metabolism ; Survival Analysis ; Treatment Outcome

المؤلفون: Welcher AA; Amgen, Inc., Thousand Oaks, California., Boedigheimer M; Amgen, Inc., Thousand Oaks, California., Kivitz AJ; Altoona Center for Clinical Research, Duncansville, Pennsylvania., Amoura Z; Groupe Hospitalier Pitié-Salpêtrière, Institut E3M, and Université Pierre et Marie Curie, Paris, France., Buyon J; New York University School of Medicine, New York, New York., Rudinskaya A; Danbury Hospital, Danbury, Connecticut., Latinis K; Kansas University Medical Center, Kansas City., Chiu K; Amgen, Inc., Thousand Oaks, California., Oliner KS; Amgen, Inc., Thousand Oaks, California., Damore MA; Amgen, Inc., Thousand Oaks, California., Arnold GE; Amgen, Inc., Thousand Oaks, California., Sohn W; Amgen, Inc., Thousand Oaks, California., Chirmule N; Amgen, Inc., Thousand Oaks, California., Goyal L; Amgen, Inc., Thousand Oaks, California., Banfield C; Amgen, Inc., Thousand Oaks, California., Chung JB; Amgen, Inc., Thousand Oaks, California.

المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2015 Oct; Vol. 67 (10), pp. 2713-22.

نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , Chemokine CXCL10/*blood , Chemokines/*genetics , Gene Expression Regulation/*drug effects , Interferon-gamma/*antagonists & inhibitors , Interferons/*physiology , Lupus Erythematosus, Systemic/*metabolism, Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized ; Chemokine CXCL10/genetics ; Chemokine CXCL10/physiology ; Chemokines/physiology ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation/physiology ; Humans ; Interferon-gamma/drug effects ; Interferon-gamma/immunology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/physiopathology ; Male ; Middle Aged ; Severity of Illness Index ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Treatment Outcome

المؤلفون: Hecht JR; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: JRHecht@mednet.ucla.edu., Douillard JY; Integrated Centres of Oncology R. Gauducheau and University of Nantes, Nantes, France., Schwartzberg L; University of Tennessee Health Science Center, Memphis, TN, USA., Grothey A; Mayo Clinic, Rochester, MN, USA., Kopetz S; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rong A; Amgen Inc., Thousand Oaks, CA, USA., Oliner KS; Amgen Inc., Thousand Oaks, CA, USA., Sidhu R; Amgen Inc., Thousand Oaks, CA, USA.

المصدر: Cancer treatment reviews [Cancer Treat Rev] 2015 Sep; Vol. 41 (8), pp. 653-9. Date of Electronic Publication: 2015 May 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1967 (Electronic) Linking ISSN: 03057372 NLM ISO Abbreviation: Cancer Treat Rev Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology, Antibodies, Monoclonal/*therapeutic use , Antibodies, Monoclonal, Humanized/*therapeutic use , ErbB Receptors/*antagonists & inhibitors , GTP Phosphohydrolases/*genetics , Membrane Proteins/*genetics , Proto-Oncogene Proteins/*genetics , ras Proteins/*genetics, Antineoplastic Agents/therapeutic use ; Cetuximab ; Humans ; Mutation ; Neoplasm Metastasis ; Panitumumab ; Pharmacogenetics ; Prognosis ; Proto-Oncogene Proteins p21(ras) ; Treatment Outcome

المؤلفون: Peeters M; Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium. Electronic address: Marc.Peeters@uza.be., Kafatos G; Center for Observational Research, Amgen Ltd, 1 Uxbridge Business Park, Sanderson Road, Uxbridge UB8 1DH, UK., Taylor A; Center for Observational Research, Amgen Ltd, 1 Uxbridge Business Park, Sanderson Road, Uxbridge UB8 1DH, UK., Gastanaga VM; Center for Observational Research, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91329-1799, USA., Oliner KS; Medical Sciences, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91329-1799, USA., Hechmati G; Health Economics, Amgen (Europe) GmbH, Dammstrasse 23, Opus 105, Zug 6301, Switzerland., Terwey JH; Medical Development, Amgen (Europe) GmbH, Zählerweg 6, Opus 192, Zug 6301, Switzerland., van Krieken JH; Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen (911), The Netherlands.

المصدر: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2015 Sep; Vol. 51 (13), pp. 1704-13. Date of Electronic Publication: 2015 Jun 03.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Biomarkers, Tumor/*genetics , Colorectal Neoplasms/*genetics , GTP Phosphohydrolases/*genetics , Membrane Proteins/*genetics , Proto-Oncogene Proteins p21(ras)/*genetics, Adolescent ; Adult ; Aged ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; DNA Mutational Analysis ; Exons ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Panitumumab ; Patient Selection ; Phenotype ; Precision Medicine ; Predictive Value of Tests ; Proto-Oncogene Proteins B-raf/genetics ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Young Adult

المؤلفون: Doshi S; Amgen Inc., Thousand Oaks, California. sdoshi@amgen.com., Gisleskog PO; SGS Exprimo NV, Mechelen, Belgium., Zhang Y; Amgen Inc., Thousand Oaks, California., Zhu M; Amgen Inc., Thousand Oaks, California., Oliner KS; Amgen Inc., Thousand Oaks, California., Loh E; Amgen Inc., South San Francisco, California., Perez Ruixo JJ; Amgen Inc., Thousand Oaks, California.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2015 Jun 01; Vol. 21 (11), pp. 2453-61. Date of Electronic Publication: 2015 Feb 24.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*administration & dosage , Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Hepatocyte Growth Factor/*immunology , Stomach Neoplasms/*drug therapy, Adult ; Aged ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal, Humanized ; Capecitabine/administration & dosage ; Cisplatin/administration & dosage ; Dose-Response Relationship, Drug ; Epirubicin/administration & dosage ; Female ; Hepatocyte Growth Factor/antagonists & inhibitors ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Stomach Neoplasms/blood ; Stomach Neoplasms/pathology