نتائج البحث - "Olivia Mekhael"

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دورية أكاديمية

Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling

المؤلفون: Steven P. Cass, Olivia Mekhael, Danya Thayaparan, Joshua J. C. McGrath, Spencer D. Revill, Matthew F. Fantauzzi, Peiyao Wang, Amir Reihani, Aaron I. Hayat, Christopher S. Stevenson, Anna Dvorkin-Gheva, Fernando M. Botelho, Martin R. Stämpfli, Kjetil Ask

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: macrophage, cigarette smoke (CS), immunopathology, tissue remodelling, fibrogenesis, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.740330/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/42863354dc984044af4890b5d31645bc

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Myeloid‐specific deletion of activating transcription factor 6 alpha increases CD11b + macrophage subpopulations and aggravates lung fibrosis

المصدر: Immunology & Cell Biology. 101:412-427

مصطلحات موضوعية: Immunology, Immunology and Allergy, Cell Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::86811152d9f53086c27b48bf2172b314
https://doi.org/10.1111/imcb.12637

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FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role

المصدر: American Journal of Respiratory Cell and Molecular Biology. 64:235-246

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Clinical Biochemistry, Inflammation, Lung injury, Bleomycin, Extracellular matrix, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Fibrosis, Pulmonary fibrosis, medicine, Molecular Biology, 030304 developmental biology, 0303 health sciences, Lung, business.industry, Interstitial lung disease, Cell Biology, respiratory system, medicine.disease, respiratory tract diseases, 3. Good health, medicine.anatomical_structure, 030104 developmental biology, FKBP, chemistry, 030228 respiratory system, Cancer research, Unfolded protein response, medicine.symptom, business, Myofibroblast, Hypersensitivity pneumonitis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e63ee9e89068286356ebacfc0eb8a
https://doi.org/10.1165/rcmb.2020-0121oc

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Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease

المؤلفون: Olivia Mekhael, Manreet Padwal, Anna Dvorkin-Gheva, Anmar Ayoub, Tamana Yousof, Soumeya Abed, Safaa Naiel, Victor Tat, Megan Vierhout, Kjetil Ask

المصدر: Chest. 157:1207-1220

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::81945c6cf8e20813e4ea37e776d3d1bc
https://doi.org/10.1016/j.chest.2019.11.009

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Mouse Models of Lung Fibrosis

المؤلفون: Olivia, Mekhael, Safaa, Naiel, Megan, Vierhout, Aaron I, Hayat, Spencer D, Revill, Soumeya, Abed, Mark D, Inman, Martin R J, Kolb, Kjetil, Ask

المصدر: Methods in molecular biology (Clifton, N.J.). 2299

مصطلحات موضوعية: Mice, Inbred C57BL, Bleomycin, Disease Models, Animal, Mice, Gene Expression Regulation, Pulmonary Fibrosis, Decision Making, Drug Evaluation, Preclinical, Animals, Computational Biology, Humans, Gene Regulatory Networks

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::eb9548e6fc6906a4c91a39a21a19091b
https://pubmed.ncbi.nlm.nih.gov/34028751

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IL‐6 mediates ER expansion during hyperpolarization of alternatively activated macrophages

المؤلفون: Anmar Ayoub, Šárka Lhoták, Ehab A. Ayaub, Anna Dvorkin-Gheva, Manreet Padwal, Chandak Upagupta, Philipp Kolb, Kjetil Ask, James Murphy, Martin Kolb, Richard C. Austin, Carl D. Richards, Hemisha Patel, Jewel Imani, Anisha Dubey, Karun Tandon, Olivia Mekhael, Jeffrey G. Dickhout

المصدر: Immunology and Cell Biology

مصطلحات موضوعية: 0301 basic medicine, XBP1, THP-1 Cells, macrophage polarization, Immunology, Macrophage polarization, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, Flow cytometry, 03 medical and health sciences, Mice, 0302 clinical medicine, Mediator, Endoribonucleases, medicine, Immunology and Allergy, Animals, Humans, Interleukin 6, IRE1‐XBP1, ER expansion, biology, medicine.diagnostic_test, Chemistry, Interleukin-6, Endoplasmic reticulum, Macrophages, Cell Biology, Original Articles, IL‐6, Macrophage Activation, Endoplasmic Reticulum Stress, profibrotic macrophages, Cell biology, Arginase, Mice, Inbred C57BL, 030104 developmental biology, Macrophage-Activating Factors, biology.protein, Original Article, Interleukin-3, Interleukin-4, Intracellular, 030215 immunology, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518faae0856261ea16bc3224d32f44c2
http://europepmc.org/articles/PMC7379543

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Mouse Models of Lung Fibrosis

المؤلفون: Olivia Mekhael, Aaron Hayat, Martin Kolb, Spencer Revill, Soumeya Abed, Kjetil Ask, Safaa Naiel, Megan Vierhout, Mark D. Inman

المصدر: Methods in Molecular Biology ISBN: 9781071613818

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Drug discovery, business.industry, Lung fibrosis, External validation, Target engagement, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, Tolerability, Lung disease, medicine, Intensive care medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e813604e5b1fdd8968e4532c3ee33f7
https://doi.org/10.1007/978-1-0716-1382-5_21

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Characterizing the Transcriptomic Signature in Circulating Monocytes and Alternatively Activated Macrophages in Idiopathic Pulmonary Fibrosis

المؤلفون: Spencer Revill, Manreet Padwal, Kjetil Ask, Asghar Naqvi, Anmar Ayoub, E. Chu, Nathan Hambly, Olivia Mekhael, Aaron Hayat, Jean-Claude Cutz, Martin Kolb, Jeremy A. Hirota, Anna Dvorkin-Gheva, Megan Vierhout

المصدر: A62. LUNG FIBROSIS: INSIGHTS FROM THE BENCH.

مصطلحات موضوعية: Transcriptome, Idiopathic pulmonary fibrosis, Pathology, medicine.medical_specialty, business.industry, medicine, medicine.disease, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0cb552891e1337b98bd866a352342e29
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2237

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Inhalation: A means to explore and optimize nintedanib’s pharmacokinetic/pharmacodynamic relationship

المؤلفون: Spencer Revill, Mark W. Surber, Gali Epstein-Shochet, A. Bruce Montgomery, Kjetil Ask, Safaa Naiel, Martin Kolb, Olivia Mekhael, Aaron Hayat, David Shitrit, Becky Bardestein-Wald, Steven Beck, Stephen Pham, Megan Vierhout

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Indoles, Pharmacology, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Fibrosis, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Lung, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, Inhalation, business.industry, Therapeutic effect, Biochemistry (medical), Fibroblasts, respiratory system, medicine.disease, Idiopathic Pulmonary Fibrosis, 3. Good health, Bronchoalveolar lavage, medicine.anatomical_structure, 030228 respiratory system, chemistry, 030220 oncology & carcinogenesis, Pharmacodynamics, Nintedanib, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0362851a07f4d08472f71fed691d55b

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Cell-specific drug targeting in the lung

المؤلفون: Aaron Hayat, Victor Tat, Safaa Naiel, Nickolas Serniuck, Kjetil Ask, Megan Vierhout, Olivia Mekhael, Anthony F. Rullo, Rebecca C. Turner, Soumeya Abed

المصدر: Biochemical Pharmacology. 190:114577

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9404dc72e8847ff4fa2078d8112772a
https://doi.org/10.1016/j.bcp.2021.114577

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