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المؤلفون: Thomas Helleday, Bishoy M. F. Hanna, Javier Benitez, Helge Gad, Carlos Benitez-Buelga, Sarah Müller, Raúl Torres-Ruiz, Olov A. Wallner, Sandra Rodriguez-Perales, Maurice Michel, Olga Loseva, Juan Miguel Baquero, Ana Osorio, Varshni Rajagopal, Torkild Visnes, Zhao Zhenjun
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Genome instability, Antimetabolites, Antineoplastic, Cancer therapy, DNA Repair, Science, Oxidative phosphorylation, medicine.disease_cause, Article, Genomic Instability, DNA Glycosylases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Telomere Homeostasis, Piperidines, Cell Line, Tumor, medicine, Humans, Enzyme Inhibitors, Multidisciplinary, Chemistry, DNA damage and repair, Cell Cycle, Drug Synergism, Base excision repair, Telomere, 3. Good health, Oxidative Stress, Telomeres, Methotrexate, 030104 developmental biology, DNA glycosylase, 030220 oncology & carcinogenesis, Cancer research, Medicine, Benzimidazoles, Reactive Oxygen Species, Oxidation-Reduction, DNA, Oxidative stress
وصف الملف: application/pdf
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المؤلفون: Saeed Eshtad, Ingrid Almlöf, Pål Stenmark, Matthieu Desroses, Armando Cázares-Körner, Evert Homan, Mikael Altun, Azita Rasti, Si Min Zhang, Torsten Schaller, Lars Bräutigam, Hanna Axelsson, Megan Carter, Adam Throup, Rosa Krimpenfort, Tobias Koolmeister, Daniel Rehling, Ann-Sofie Jemth, Thomas Lundbäck, Elisee Wiita, Thomas Helleday, Anna Hagenkort, Brent D. G. Page, Martin Scobie, Ulrika Warpman Berglund, Linda Pudelko, Antonio Sarno, Andreas Krämer, Christina Kalderén, Juliane Kutzner, Olov A. Wallner, Shruti Regmi, Mona Göttmann, Sean G. Rudd, Nicholas C.K. Valerie, Stefan Knapp, Olga Loseva
المصدر: Nature chemical biology
Nature Chemical Biologyمصطلحات موضوعية: Models, Molecular, GTP', acute lymphoblastic leukaemia, Protein Conformation, Plasma protein binding, Nudix hydrolase, Article, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Drug Development, Escherichia coli, Structure–activity relationship, Humans, Binding site, Pyrophosphatases, Molecular Biology, Structural analog, 030304 developmental biology, 0303 health sciences, TH1760, Binding Sites, Thiopurine methyltransferase, biology, Chemistry, thiopurines, 030302 biochemistry & molecular biology, small molecule inhibitor, 6-thio-dGTP, Cell Biology, 3. Good health, Inorganic Pyrophosphatase, Biochemistry, Drug Design, biology.protein, Nucleic acid, NUDT15, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Thomas Helleday, Jonas S. Erjefält, Christina Kalderén, Olov A. Wallner, Christoffer Karlsson, Ravi K. V. Bhongir, Lloyd Tanner, Moritz Heusel, Arne Egesten, Tirthankar Mohanty, Carl-Magnus Clausson, A.B. Single, Cecilia Andersson, Johan Malmström, Riya Oommen
مصطلحات موضوعية: Lung, business.industry, DNA repair, medicine.medical_treatment, Pirfenidone, respiratory system, medicine.disease, respiratory tract diseases, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Cytokine, medicine.anatomical_structure, chemistry, Pulmonary fibrosis, medicine, Cancer research, Nintedanib, business, Myofibroblast, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ffb3ae8ddef71a607bec4eaf9262b30c
https://doi.org/10.21203/rs.3.rs-990197/v1 -
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المؤلفون: Christina Kalderén, Maurice Michel, Olov A. Wallner, Geoffrey Masuyer, Oliver Mortusewicz, Carlos Benitez-Buelga, Armando Cázares-Körner, Ann-Sofie Jemth, Thomas Helleday, Kumar Sanjiv, Bishoy M. F. Hanna, Olga Loseva, Pål Stenmark, Torkild Visnes, Ulrika Warpman Berglund
المصدر: Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response.
مصطلحات موضوعية: Oncogene, DNA damage, DNA glycosylase, Chemistry, Cancer cell, Cancer research, medicine, Cancer, Base excision repair, medicine.disease, Chromatin, Proinflammatory cytokine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a5cb537a489d65ace2913a618d25ac60
https://doi.org/10.3390/iecc2021-09213 -
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المؤلفون: Olov A. Wallner, Florian Ortis, Kirill Mamonov, Maurice Michel, Dana Michel
المصدر: Chemistry–Methods
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 05 social sciences, 050301 education, Spike Protein, General Medicine, Computational biology, 0503 education, 01 natural sciences, 0104 chemical sciences
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المؤلفون: Thomas Helleday, Shruti Regmi, Roni H. G. Wright, Nicholas C.K. Valerie, Hanna Axelsson, Sean G. Rudd, Sabin Llona-Minguez, Helena Almqvist, Pål Stenmark, Evert Homan, Brent D. G. Page, Olov A. Wallner, Martin Scobie, Fredrik Jeppsson, Thomas Lundbäck, Kia Strömberg, Olga Loseva, Jofre Font-Mateu, Rebecka Isaksson, Pawel Baranczewski, Ingrid Almlöf, Anna-Lena Gustavsson, Miguel Beato, Megan Carter, Ann-Sofie Jemth
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communicationsمصطلحات موضوعية: Science, General Physics and Astronomy, Breast Neoplasms, HL-60 Cells, 02 engineering and technology, General Biochemistry, Genetics and Molecular Biology, Target validation, Substrate Specificity, 03 medical and health sciences, Breast cancer, Adenosine Triphosphate, Text mining, Cell Line, Tumor, Block (telecommunications), Humans, Medicine, Drug discovery and development, Enzyme Inhibitors, Pyrophosphatases, lcsh:Science, Author Correction, Hormone signaling, Cell Proliferation, 030304 developmental biology, Cell Nucleus, Adenosine Diphosphate Ribose, 0303 health sciences, Multidisciplinary, Molecular Structure, business.industry, General Chemistry, 021001 nanoscience & nanotechnology, 3. Good health, Screening, Cancer research, lcsh:Q, Female, RNA Interference, Breast cancer cells, Progestins, 0210 nano-technology, business, Signal Transduction
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المؤلفون: Therese Pham, Kumar Sanjiv, T. Meijer, Jonas Nilsson, Christina Kalderén, Rozbeh Jafari, Fabienne Z. Gaugaz, Torkild Visnes, Annika Lindqvist, Prasad B. Wakchaure, Aleksandr Manoilov, Per Artursson, Gianluca Maddalo, U. Warpman Berglund, Olov A. Wallner, Pawel Baranczewski, V. Nagpal, Azita Rasti, Aljona Saleh, Elisee Wiita, Sean G. Rudd, Ann-Sofie Jemth, Martin Henriksson, Ingrid Almlöf, Helge Gad, Camilla Göktürk, Tobias Koolmeister, Alexey Chernobrovkin, Evert Homan, Thomas Helleday, Vassilis G. Gorgoulis, Lars Bräutigam, Berglind Osk Einarsdottir, Brinton Seashore-Ludlow, Y. Kallberg, Olga Loseva, T-C Lee, Janne Lehtiö, Sanjay R. Borhade, Björn Platzack, Patrick Herr, Anne M. Filppula, Karl S. A. Vallin, Roman A. Zubarev, Ioannis S. Pateras, Martin Scobie, Nicolaas G. M. Schipper
المصدر: Annals of Oncology
Annals of oncology : official journal of the European Society for Medical Oncologyمصطلحات موضوعية: Proto-Oncogene Proteins B-raf, 0301 basic medicine, DNA damage, Pharmacology, Mice, Pharmaceutical Sciences, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, cancer, Nucleotide, Enzyme Inhibitors, RNA, Small Interfering, Pharmaceutical sciences, reactive oxygen species, chemistry.chemical_classification, Cancer och onkologi, Nucleotides, business.industry, NUDT1 Gene, Deoxyguanosine, Cancer, DNA, Hematology, Farmaceutiska vetenskaper, medicine.disease, Xenograft Model Antitumor Assays, small molecule inhibitors, Small molecule, Phosphoric Monoester Hydrolases, MTH1, 3. Good health, DNA Repair Enzymes, Pyrimidines, 030104 developmental biology, Oncology, chemistry, 8-Hydroxy-2'-Deoxyguanosine, Cancer and Oncology, Cancer cell, business, Oxidation-Reduction
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a71ea01ac7d0533472602aea288f43
https://doi.org/10.1093/annonc/mdw429 -
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المؤلفون: Karl S. A. Vallin, Cynthia B.J. Paulin, Olov A. Wallner, Thomas Helleday, Jiaxi Zhang, Brinton Seashore-Ludlow, Maurice Michel, Martin Scobie, Ulrika Warpman Berglund, Evert Homan, Mattias Hedenström, Torkild Visnes, Andreas Schmidt, Elisee Wiita, Annika Jenmalm-Jensen
المصدر: 11642-11656
ACS Omega
ACS Omega, Vol 4, Iss 7, Pp 11642-11656 (2019)مصطلحات موضوعية: Thermal shift assay, Human dna, General Chemical Engineering, Druggability, NEIL1, Computational biology, 010402 general chemistry, 01 natural sciences, Article, lcsh:Chemistry, 03 medical and health sciences, Endonuclease, chemistry.chemical_compound, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Assay, Biochemistry and Molecular Biology, General Chemistry, 0104 chemical sciences, lcsh:QD1-999, DNA glycosylase, biology.protein, DNA, Biokemi och molekylärbiologi
وصف الملف: application/pdf
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المؤلفون: Carlos Benitez-Buelga, Christina Kalderén, T. Helleday, Martin Scobie, Ulrika Warpman Berglund, Karthick Marimuthu, Olov A. Wallner, Evert Homan, Kumar Sanjiv, Varshni Rajagopal
المصدر: Cancer Research. 80:4799-4799
مصطلحات موضوعية: Drug, Cancer Research, Anti malarial, Proguanil, business.industry, media_common.quotation_subject, Pharmacology, Cancer treatment, Oncology, Cancer cell, medicine, business, Repurposing, medicine.drug, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9b05c90221fc3618fd7bf39687e64ca1
https://doi.org/10.1158/1538-7445.am2020-4799 -
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المؤلفون: Camilla Göktürk, Elisee Wiita, Olga Loseva, Oliver Mortusewicz, Armando Cázares-Körner, Per Artursson, Aleksandr Manoilov, Mikael Altun, Petar Iliev, Ann-Sofie Jemth, Dag Ivanic, Annika Jenmalm Jensen, Roman A. Zubarev, Evert Homan, Azita Rasti, Thomas Helleday, Lang Pan, Istvan Boldogh, Catharina Von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Wenjing Hao, Pawel Baranczewski, Martin Scobie, Bishoy M. F. Hanna, Therese Pham, Ulrika Warpman Berglund, Stella Karsten, Cynthia B.J. Paulin, Geoffrey Masuyer, Antonio Sarno, Pål Stenmark, Torkild Visnes, Juan Astorga-Wells, Christina Kalderén, Olov A. Wallner, Kumar Sanjiv, Xueqing Ba, Maurice Grube, Hans E. Krokan
المصدر: Science
مصطلحات موضوعية: 0301 basic medicine, Guanine, DNA Repair, DNA repair, Gene Expression, Inflammation, Systemic inflammation, Article, DNA Glycosylases, Proinflammatory cytokine, Gene Knockout Techniques, Jurkat Cells, Mice, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Gene expression, medicine, Animals, Humans, Enzyme Inhibitors, Promoter Regions, Genetic, chemistry.chemical_classification, Reactive oxygen species, Multidisciplinary, Tumor Necrosis Factor-alpha, Anti-Inflammatory Agents, Non-Steroidal, NF-kappa B, Mice, Mutant Strains, 3. Good health, Cell biology, HEK293 Cells, 030104 developmental biology, chemistry, DNA glycosylase, 030220 oncology & carcinogenesis, Benzimidazoles, Tumor necrosis factor alpha, medicine.symptom
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccdba340149cf0ea8e5f4b68a6c3a36
https://hdl.handle.net/11250/2577000