المؤلفون: Khan ZS; Department of Mechanical Engineering, Texas Tech University, 2703 7th Street, Lubbock, 79409, Texas, USA., Hussain F; Department of Mechanical Engineering, Texas Tech University, 2703 7th Street, Lubbock, 79409, Texas, USA, fazle.hussain@ttu.edu.

المصدر: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2024 Jun 12; Vol. 58 (3), pp. 250-272.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Physiol Biochem Press GmbH & Co KG Country of Publication: Germany NLM ID: 9113221 Publication Model: Print Cited Medium: Internet ISSN: 1421-9778 (Electronic) Linking ISSN: 10158987 NLM ISO Abbreviation: Cell Physiol Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Actins*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Signal Transduction*/drug effects , Cell Movement*/drug effects , Mechanistic Target of Rapamycin Complex 2*/metabolism , Mechanistic Target of Rapamycin Complex 2*/antagonists & inhibitors , Macrolides*/pharmacology , Vacuolar Proton-Translocating ATPases*/metabolism , Vacuolar Proton-Translocating ATPases*/antagonists & inhibitors , Cell Proliferation*/drug effects , TOR Serine-Threonine Kinases*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Heterochromatin*/metabolism, Humans ; Cell Line, Tumor ; Female ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 1/antagonists & inhibitors ; MCF-7 Cells

المؤلفون: Min W; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.).; Cardiovascular Medical Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (W.M.)., Qin L; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., Zhang H; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., López-Giráldez F; Yale Center for Genomic Analysis, Department of Genetics (F.L.-G.), New Haven, CT., Jiang N; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., Kim Y; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., Mohan VK; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., Su M; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.)., Murray KN; Department of Neurobiology, Yale University School of Medicine (K.N.M., J.G.), New Haven, CT., Grutzendler J; Department of Neurobiology, Yale University School of Medicine (K.N.M., J.G.), New Haven, CT., Zhou JH; Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT (W.M., L.Q., H.Z., N.J., Y.K., V.K.M., M.S., J.H.Z.).

المصدر: Circulation research [Circ Res] 2024 Aug 02; Vol. 135 (4), pp. e94-e113. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction* , Hemangioma, Cavernous, Central Nervous System*/metabolism , Hemangioma, Cavernous, Central Nervous System*/genetics , Hemangioma, Cavernous, Central Nervous System*/pathology , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Endothelial Progenitor Cells*/metabolism , Endothelial Progenitor Cells*/pathology, Animals ; Mice ; Brain/metabolism ; Brain/pathology ; Brain/blood supply ; Mice, Knockout ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Apoptosis Regulatory Proteins/metabolism ; Apoptosis Regulatory Proteins/genetics ; Mice, Inbred C57BL ; Membrane Proteins/metabolism ; Membrane Proteins/genetics

المؤلفون: Fan K; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China., Wang Y; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China., Bian J; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China.; College of Pharmacy, Soochow University, Suzhou, Jiangsu, People's Republic of China., Sun Y; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China.; College of Pharmacy, Soochow University, Suzhou, Jiangsu, People's Republic of China., Dou J; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China., Pan J; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China. panzy1122@163.com., Yu Y; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou City, 215004, Jiangsu, People's Republic of China. haoyyl0902@163.com.

المصدر: Investigational new drugs [Invest New Drugs] 2024 Aug; Vol. 42 (4), pp. 418-427. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms*/drug therapy , Colonic Neoplasms*/metabolism , Imidazoles*/pharmacology , Imidazoles*/therapeutic use , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 2*/antagonists & inhibitors , Mechanistic Target of Rapamycin Complex 2*/metabolism , Metabolomics*/methods , Sirolimus*/pharmacology , Sirolimus*/therapeutic use , Triazines*/pharmacology , Triazines*/therapeutic use, Humans ; Cell Proliferation/drug effects ; HCT116 Cells ; Liquid Chromatography-Mass Spectrometry ; Tandem Mass Spectrometry

المؤلفون: Deyama S; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan., Sugie R; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan., Tabata M; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan., Kaneda K; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

المصدر: Nutritional neuroscience [Nutr Neurosci] 2024 Aug; Vol. 27 (8), pp. 795-808. Date of Electronic Publication: 2023 Sep 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Tomatine*/analogs & derivatives , Antidepressive Agents*/pharmacology , Antidepressive Agents*/administration & dosage , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Prefrontal Cortex*/drug effects , Prefrontal Cortex*/metabolism , Lipopolysaccharides* , Depression*/drug therapy , Depression*/chemically induced , Disease Models, Animal*, Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Behavior, Animal/drug effects

المؤلفون: Smith SF; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA., Islam AFMT; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA., Alimukhamedov S; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA., Weiss ET; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA., Charest PG; Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA; University of Arizona Cancer Center, Tucson, Arizona, USA. Electronic address: pcharest@arizona.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jul; Vol. 300 (7), pp. 107423. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dictyostelium*/metabolism , Dictyostelium*/genetics , Mechanistic Target of Rapamycin Complex 2*/metabolism , Mechanistic Target of Rapamycin Complex 2*/genetics , Signal Transduction* , ras Proteins*/metabolism, Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/chemistry ; Cyclic AMP/metabolism

المؤلفون: Xiao D; Department of Thoracic surgery, The First Affiliated Hospital of Jinan University, Guangzhou City, China., Liu T; Department of Internal Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China., Pan Y; Department of Thoracic Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Aug; Vol. 38 (8), pp. e23803.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , B7 Antigens*/metabolism , B7 Antigens*/immunology , Immune Checkpoint Inhibitors*/pharmacology, Animals ; Mice ; Mice, Inbred C57BL ; Cell Line, Tumor ; Tumor Microenvironment/immunology

المؤلفون: Sobsey CA; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Froehlich BC; University of Victoria-Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Mitsa G; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Ibrahim S; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Popp R; MRM Proteomics Inc., Montreal, QC, Canada., Zahedi RP; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.; Manitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, Canada.; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.; CancerCare Manitoba Research Institute, Winnipeg, MB, Canada., de Bruin EC; Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Borchers CH; Segal Cancer Proteomics Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Division of Experimental Medicine, McGill University, Montreal, QC, Canada.; Gerald Bronfman Department of Oncology, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.; Department of Pathology, McGill University, Montreal, QC, Canada., Batist G; Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada.; McGill Centre for Translational Research in Cancer, Lady Davis Institute, Montreal, QC, Canada.

المصدر: Cancer research communications [Cancer Res Commun] 2024 Aug 01; Vol. 4 (8), pp. 2058-2074.

نوع المنشور: Journal Article; Clinical Trial, Phase I

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Class I Phosphatidylinositol 3-Kinases*/genetics , Class I Phosphatidylinositol 3-Kinases*/metabolism , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Pyrimidines*/pharmacology , Pyrimidines*/therapeutic use , Protein Biosynthesis*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism, Humans ; Female ; Cell Line, Tumor ; Mutation ; Proteomics/methods ; Pyrroles/pharmacology ; Pyrroles/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/genetics

المؤلفون: Meyer H; Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany; email: hemmo.meyer@uni-due.de., Kravic B; Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany; email: hemmo.meyer@uni-due.de.

المصدر: Annual review of biochemistry [Annu Rev Biochem] 2024 Aug; Vol. 93 (1), pp. 367-387. Date of Electronic Publication: 2024 Jul 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985150R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-4509 (Electronic) Linking ISSN: 00664154 NLM ISO Abbreviation: Annu Rev Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Lysosomes*/metabolism , Autophagy* , Signal Transduction* , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , Endosomes*/metabolism, Humans ; Animals ; Endocytosis ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/genetics

المؤلفون: Cui N; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China., Ding F; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

المصدر: Drug design, development and therapy [Drug Des Devel Ther] 2024 Jul 23; Vol. 18, pp. 3157-3173. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

مواضيع طبية MeSH: Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , Molecular Docking Simulation* , Cell Proliferation*/drug effects , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Diosgenin*/pharmacology , Diosgenin*/chemistry, Humans ; Apoptosis/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Disease Progression ; Drug Screening Assays, Antitumor ; Minor Histocompatibility Antigens/metabolism ; Minor Histocompatibility Antigens/genetics ; Dose-Response Relationship, Drug ; Tumor Cells, Cultured

المؤلفون: Kitai H; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Choi PH; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang YC; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Boyer JA; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Whaley A; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pancholi P; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Thant C; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reiter J; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chen K; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Markov V; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Taniguchi H; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yamaguchi R; Division of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan., Evans J; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Jiang J; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Lee B; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Wildes D; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., de Stanchina E; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Smith JAM; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Singh M; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA. msingh@revmed.com., Rosen N; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rosenn@mskcc.org.

المصدر: Nature communications [Nat Commun] 2024 Jul 19; Vol. 15 (1), pp. 6076. Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Drug Synergism*, Humans ; Animals ; Cell Line, Tumor ; Mice ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Protein Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays ; Signal Transduction/drug effects ; Cyclin D1/metabolism ; Cyclin D1/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Female ; Bcl-2-Like Protein 11/metabolism ; Bcl-2-Like Protein 11/genetics