المؤلفون: Korenjak M, Temiz NA, Keita S, Chavanel B, Renard C, Sirand C, Cahais V, Mayel T, Vevang KR, Jacobs FC, Guo J, Smith WE, Oram MK, Tăbăran FA, Ahlat O, Cornax I, O'Sullivan MG, Das S, Nandi SP, Cheng Y, Alexandrov LB, Balbo S, Hecht SS, Senkin S, Virard F, Peterson LA, Zavadil J

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Oram MK; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Baxley RM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Simon EM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Lin K; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Computer Science & Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Chang YC; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Wang L; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Myers CL; Department of Computer Science & Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Bielinsky AK; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: azu3jn@virginia.edu.

المصدر: DNA repair [DNA Repair (Amst)] 2024 Mar; Vol. 135, pp. 103646. Date of Electronic Publication: 2024 Feb 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-7856 (Electronic) Linking ISSN: 15687856 NLM ISO Abbreviation: DNA Repair (Amst) Subsets: MEDLINE

مواضيع طبية MeSH: Genomic Instability* , DNA Repair*, Humans ; DNA Replication ; Mitosis ; Saccharomyces cerevisiae/genetics ; Nuclear Proteins/genetics ; Transcription Factors

المؤلفون: Lin CJ; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Herisson F; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Le H; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Jaafar N; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Chetal K; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Oram MK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Flynn KL; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Gavrilles EP; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Sadreyev RI; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Schiffino FL; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Charlestown, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.

المصدر: Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113141. Date of Electronic Publication: 2023 Sep 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Microglia*/pathology , Alzheimer Disease*/pathology, Mice ; Animals ; Mast Cells/pathology ; Mice, Transgenic ; Cognition ; Immunologic Factors

المؤلفون: Chang YC; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minnesota, MN 55455, USA., Oram MK; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minnesota, MN 55455, USA., Bielinsky AK; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minnesota, MN 55455, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 May 20; Vol. 22 (10). Date of Electronic Publication: 2021 May 20.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Genomic Instability/*genetics , Small Ubiquitin-Related Modifier Proteins/*genetics , Sumoylation/*genetics , Ubiquitin/*genetics , Ubiquitin-Protein Ligases/*genetics, Animals ; DNA Repair/genetics ; Humans

المؤلفون: Peterson LA; Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Oram MK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Flavin M; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Seabloom D; AeroCore Testing Service, Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, United States., Smith WE; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., O'Sullivan MG; College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108, United States.; Comparative Pathology Shared Resource, Masonic Cancer Center, University of Minnesota, St. Paul, Minnesota 55455, United States., Vevang KR; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Upadhyaya P; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Stornetta A; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Floeder AC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Ho YY; Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota 55455, United States., Zhang L; Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota 55455, United States., Hecht SS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, United States., Balbo S; Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Wiedmann TS; Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States.

المصدر: Chemical research in toxicology [Chem Res Toxicol] 2021 Mar 15; Vol. 34 (3), pp. 723-732. Date of Electronic Publication: 2021 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Aldehydes/*toxicity , Carbon Dioxide/*toxicity , Carcinogens/*toxicity , Lung Neoplasms/*chemically induced , Nitrosamines/*toxicity, Administration, Inhalation ; Aldehydes/administration & dosage ; Aldehydes/chemistry ; Animals ; Carbon Dioxide/administration & dosage ; Carbon Dioxide/chemistry ; Carcinogens/administration & dosage ; Carcinogens/chemistry ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Lung Neoplasms/metabolism ; Mice ; Molecular Structure ; Nitrosamines/administration & dosage ; Nicotiana/chemistry

المؤلفون: Baxley RM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Leung W; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Schmit MM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Matson JP; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA., Yin L; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Oram MK; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Wang L; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Taylor J; Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Hedberg J; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Rogers CB; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Harvey AJ; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Basu D; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Taylor JC; Wellcome Centre Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK., Pagnamenta AT; Wellcome Centre Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Oxford, OX3 7BN, UK., Dreau H; Department of Haematology, University of Oxford, Oxford, OX3 7BN, UK., Craft J; Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Ormondroyd E; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hendrickson EA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Mace EM; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Orange JS; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Aihara H; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA., Stewart GS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK., Blair E; Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Cook JG; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA., Bielinsky AK; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA. bieli003@umn.edu.

المصدر: Nature communications [Nat Commun] 2021 Mar 12; Vol. 12 (1), pp. 1626. Date of Electronic Publication: 2021 Mar 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Alleles* , Telomere Shortening*, Cardiomyopathies/*genetics , Minichromosome Maintenance Proteins/*genetics , Minichromosome Maintenance Proteins/*immunology, Cell Cycle Proteins/metabolism ; Cell Line ; DNA Replication ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Endonucleases/genetics ; Endonucleases/metabolism ; Humans ; Killer Cells, Natural

المؤلفون: Griciuc A; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Patel S; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Federico AN; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Choi SH; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Innes BJ; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Oram MK; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Cereghetti G; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Institute of Biochemistry, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland., McGinty D; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Anselmo A; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Sadreyev RI; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Hickman SE; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., El Khoury J; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.

المصدر: Neuron [Neuron] 2019 Sep 04; Vol. 103 (5), pp. 820-835.e7. Date of Electronic Publication: 2019 Jul 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

مواضيع طبية MeSH: Cognition*, Alzheimer Disease/*genetics , Amyloid beta-Peptides/*metabolism , Brain/*metabolism , Membrane Glycoproteins/*genetics , Microglia/*metabolism , Plaque, Amyloid/*pathology , Receptors, Immunologic/*genetics , Sialic Acid Binding Ig-like Lectin 3/*genetics, Acute-Phase Reaction/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Brain/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Mice ; Mice, Knockout ; Microglia/pathology ; Phagocytosis/genetics

المؤلفون: Suh J; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address: suh.jaehong@mgh.harvard.edu., Romano DM; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Nitschke L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA., Herrick SP; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., DiMarzio BA; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Dzhala V; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Bae JS; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Oram MK; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Zheng Y; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Hooli B; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Mullin K; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Gennarino VA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA., Wasco W; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Schmahmann JD; Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Albers MW; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Zoghbi HY; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hzoghbi@bcm.edu., Tanzi RE; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.

المصدر: Cell [Cell] 2019 Aug 22; Vol. 178 (5), pp. 1159-1175.e17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*pathology , Amyloid Precursor Protein Secretases/*metabolism , Ataxin-1/*metabolism , Brain/*metabolism, Alzheimer Disease/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Ataxin-1/deficiency ; Ataxin-1/genetics ; Brain/pathology ; CA2 Region, Hippocampal/metabolism ; CA2 Region, Hippocampal/pathology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Female ; Gene Frequency ; Humans ; Male ; Mice ; Mice, Transgenic ; Neurogenesis ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Trinucleotide Repeats/genetics ; Up-Regulation

المؤلفون: Choi SH; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Bylykbashi E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Chatila ZK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Lee SW; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Pulli B; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA., Clemenson GD; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Kim E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Rompala A; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Oram MK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Asselin C; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Aronson J; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Zhang C; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Miller SJ; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Lesinski A; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., Chen JW; Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA., Kim DY; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA., van Praag H; Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA., Spiegelman BM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Gage FH; Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tanzi@helix.mgh.harvard.edu.

المصدر: Science (New York, N.Y.) [Science] 2018 Sep 07; Vol. 361 (6406).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Cognition* , Exercise* , Neurogenesis*/drug effects, Alzheimer Disease/*psychology , Alzheimer Disease/*therapy , Brain-Derived Neurotrophic Factor/*metabolism , Hippocampus/*cytology, Alzheimer Disease/pathology ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Carbazoles/administration & dosage ; Carbazoles/pharmacology ; Cell Death ; Disease Models, Animal ; Female ; Fibronectins ; Humans ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Transgenic ; Physical Conditioning, Animal ; Wnt3 Protein/genetics

المؤلفون: Chatila ZK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Kim E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Berlé C; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Bylykbashi E; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Rompala A; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Oram MK; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Gupta D; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Kwak SS; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Kim YH; Biomedical Omics Group, Korea Basic Science Institute, Cheongju-si, Chungbuk 363-883, Republic of Korea., Kim DY; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Choi SH; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129., Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129.

المصدر: ENeuro [eNeuro] 2018 Aug 03; Vol. 5 (4). Date of Electronic Publication: 2018 Aug 03 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: eCollection Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid Precursor Protein Secretases/*physiology , Aspartic Acid Endopeptidases/*physiology , Cell Differentiation/*physiology , Cell Proliferation/*physiology , Hippocampus/*physiology , Neurogenesis/*physiology , Neurons/*physiology, Age Factors ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout