المؤلفون: Accili, D, Talchai, SC, Kim-Muller, JY, Cinti, F, Ishida, E, Ordelheide, AM, Kuo, T, Fan, J, Son, J

المصدر: Diabetes, obesity & metabolism, vol 18 Suppl 1, iss Suppl 1

مصطلحات موضوعية: Animals, Humans, Mice, Diabetes Mellitus, Type 2, Insulin, Insulin-Secreting Cells, Forkhead Transcription Factors, Cell Dedifferentiation, Insulin Secretion, aldehyde dehydrogenase, biomarker, genetics, human disease, lineage marker, progenitor cells, regeneration, therapeutic failure, Diabetes, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Affordable and Clean Energy, Clinical Sciences, Endocrinology & Metabolism

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7j1550xj

المؤلفون: Ordelheide AM; Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University Tübingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hrabě de Angelis M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Chair for Experimental Genetics, Technical University Munich, Neuherberg, Germany., Häring HU; Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University Tübingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology & Clinical Chemistry, University Hospital Tübingen, Germany.; Interfaculty Center for Pharmacogenomics & PharmaResearch at the Eberhard Karls University Tübingen, Germany., Staiger H; Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University Tübingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Interfaculty Center for Pharmacogenomics & PharmaResearch at the Eberhard Karls University Tübingen, Germany.; Institute of Pharmaceutical Sciences, Department of Pharmacy & Biochemistry, Eberhard Karls University Tübingen, Germany.

المصدر: Pharmacogenomics [Pharmacogenomics] 2018 Apr; Vol. 19 (6), pp. 577-587. Date of Electronic Publication: 2018 Mar 27.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 100897350 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8042 (Electronic) Linking ISSN: 14622416 NLM ISO Abbreviation: Pharmacogenomics Subsets: MEDLINE

مواضيع طبية MeSH: Pharmacogenetics*, Diabetes Mellitus, Type 2/*drug therapy , Insulin/*genetics , Metformin/*therapeutic use, Administration, Oral ; Diabetes Mellitus, Type 2/genetics ; Humans ; Hypoglycemic Agents/therapeutic use ; Metformin/adverse effects

المؤلفون: Ordelheide AM; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany., Böhm A; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Kempe-Teufel D; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Wagner R; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Machicao F; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany., Heni M; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Stefan N; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Fritsche A; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Nutritional and Preventive Medicine, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany., Häring HU; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; Interfaculty Center for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany., Staiger H; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.; German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany.; Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany.; Interfaculty Center for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany.; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany.

المصدر: PloS one [PLoS One] 2017 May 04; Vol. 12 (5), pp. e0177148. Date of Electronic Publication: 2017 May 04 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Fasting*, Glucagon/*blood , Glucose/*administration & dosage , Sodium-Glucose Transporter 2/*genetics, Adult ; Blood Glucose/analysis ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors

المؤلفون: Accili D; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York. da230@cumc.columbia.edu., Talchai SC; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Kim-Muller JY; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Cinti F; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Ishida E; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Ordelheide AM; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Kuo T; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Fan J; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Son J; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York.

المصدر: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2016 Sep; Vol. 18 Suppl 1, pp. 117-22.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

مواضيع طبية MeSH: Cell Dedifferentiation*, Diabetes Mellitus, Type 2/*metabolism , Forkhead Transcription Factors/*metabolism , Insulin/*metabolism , Insulin-Secreting Cells/*cytology, Animals ; Humans ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Mice

المؤلفون: Ordelheide AM; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany., Gommer N; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Böhm A; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Hermann C; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany., Thielker I; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany., Machicao F; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany., Fritsche A; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany; Department of Internal Medicine, Division of Nutritional and Preventive Medicine, University Hospital Tübingen, Tübingen, Germany., Stefan N; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Häring HU; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany., Staiger H; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany. Electronic address: harald.staiger@med.uni-tuebingen.de.

المصدر: Molecular metabolism [Mol Metab] 2016 Feb 13; Vol. 5 (4), pp. 305-316. Date of Electronic Publication: 2016 Feb 13 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: eCollection Cited Medium: Print ISSN: 2212-8778 (Print) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: PubMed not MEDLINE

المؤلفون: Hartung A; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany., Ordelheide AM; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany., Staiger H; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany., Melzer M; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany., Häring HU; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany., Lammers R; Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany. Electronic address: reiner.lammers@med.uni-tuebingen.de.

المصدر: Biochimica et biophysica acta [Biochim Biophys Acta] 2013 Dec; Vol. 1833 (12), pp. 2803-2811. Date of Electronic Publication: 2013 Jul 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*/drug effects, Insulin/*metabolism , Microfilament Proteins/*metabolism , Myoblasts/*metabolism , Proto-Oncogene Proteins c-abl/*metabolism , Proto-Oncogene Proteins c-akt/*metabolism , Vesicular Transport Proteins/*metabolism, Adult ; Animals ; Cells, Cultured ; Down-Regulation/drug effects ; Endocytosis/drug effects ; Enzyme Activation/drug effects ; Female ; Gene Knockdown Techniques ; Glycogen/biosynthesis ; Humans ; Insulin/pharmacology ; Male ; Mice ; Myoblasts/drug effects ; Myoblasts/enzymology ; Phosphorylation/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Insulin/metabolism ; Substrate Specificity/drug effects

المؤلفون: Ordelheide AM; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholz Centre Munich at the University of Tübingen, Germany ; German Center for Diabetes Research (DZD), Neuherberg, Germany., Gerst F, Rothfuss O, Heni M, Haas C, Thielker I, Herzberg-Schäfer S, Böhm A, Machicao F, Ullrich S, Stefan N, Fritsche A, Häring HU, Staiger H

المصدر: Molecular metabolism [Mol Metab] 2013 Jun 17; Vol. 2 (3), pp. 243-55. Date of Electronic Publication: 2013 Jun 17 (Print Publication: 2013).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: eCollection Cited Medium: Print ISSN: 2212-8778 (Print) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: PubMed not MEDLINE

المؤلفون: Böhm A; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany., Ordelheide AM, Machann J, Heni M, Ketterer C, Machicao F, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H

المصدر: PloS one [PLoS One] 2012; Vol. 7 (3), pp. e34035. Date of Electronic Publication: 2012 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation*, Adiposity/*genetics , Eye Proteins/*genetics , Insulin Resistance/*genetics , Leptin/*blood , Nerve Growth Factors/*genetics , Obesity/*physiopathology , Serpins/*genetics, Adult ; Female ; Glucose Tolerance Test ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide

المؤلفون: Ordelheide AM; Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Member of the German Center for Diabetes Research (DZD e.V.), Eberhard Karls University Tübingen, Tübingen, Germany., Heni M, Thamer C, Machicao F, Fritsche A, Stefan N, Häring HU, Staiger H

المصدر: European journal of clinical investigation [Eur J Clin Invest] 2011 Dec; Vol. 41 (12), pp. 1323-9. Date of Electronic Publication: 2011 May 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance/*physiology , Muscle Cells/*metabolism , Muscle Fibers, Skeletal/*metabolism , PPAR delta/*metabolism , Thiazoles/*metabolism, Blood Glucose/metabolism ; Body Mass Index ; Cells, Cultured/metabolism ; Female ; Gene Expression Regulation ; Glucose Tolerance Test ; Humans ; Insulin Resistance/genetics ; Lipid Metabolism/genetics ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Regression Analysis

المؤلفون: Ordelheide AM; Division of Endocrinology, Department of Internal Medicine, Eberhard Karls University Tübingen and German Center for Diabetes Research (DZD eV), Tübingen, Germany., Heni M, Gommer N, Gasse L, Haas C, Guirguis A, Machicao F, Häring HU, Staiger H

المصدر: Experimental diabetes research [Exp Diabetes Res] 2011; Vol. 2011, pp. 692536. Date of Electronic Publication: 2011 Jan 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101274844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1687-5303 (Electronic) Linking ISSN: 16875214 NLM ISO Abbreviation: Exp Diabetes Res Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Metabolism*, Muscle Cells/*metabolism , PPAR delta/*genetics , Receptors, Adiponectin/*genetics, Adult ; Cadherins/genetics ; Cells, Cultured ; Female ; Gene Expression ; Glucose Clamp Technique ; Glucose Tolerance Test ; Humans ; Linear Models ; Male ; Muscle Cells/chemistry ; Polymorphism, Single Nucleotide ; RNA, Messenger/analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Triglycerides/blood