نتائج البحث - "Organic Cation Transport Proteins/genetics"

1

Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics

المؤلفون: Gustaf J. Wellhagen, Kim Brøsen, Mette Marie Hougaard Christensen, Benjamin Guiastrennec, Maria C. Kjellsson, Tore Bjerregaard Stage

المصدر: Stage, T B, Wellhagen, G, Christensen, M M H, Guiastrennec, B, Brøsen, K & Kjellsson, M C 2019, ' Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics ', Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 1, pp. 105-114 . https://doi.org/10.1111/bcpt.13139

مصطلحات موضوعية: Adult, Time Factors, Organic Cation Transport Proteins, Pharmacogenomic Variants, Renal function, Administration, Oral, Biological Availability, Urine, Biological Variation, Population/physiology, Biology, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Models, Biological, Polymorphism, Single Nucleotide, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Metformin/administration & dosage, Pharmacokinetics, medicine, Hypoglycemic Agents, Humans, Gastrointestinal Transit, Volume of distribution, Clinical Trials as Topic, Biological Variation, Individual, Gastrointestinal Absorption/physiology, Acidosis, Lactic/chemically induced, Gastrointestinal Transit/physiology, General Medicine, Middle Aged, Hypoglycemic Agents/administration & dosage, Metformin, Healthy Volunteers, NONMEM, Biological Variation, Population, Gastrointestinal Absorption, 030220 oncology & carcinogenesis, Renal physiology, Acidosis, Lactic, medicine.drug, Organic Cation Transport Proteins/genetics

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34b5c811e89bad20db91948e42c2337
https://findresearcher.sdu.dk:8443/ws/files/146453151/Using_a_semi_mechanistic_model_to_identify_the_main_sources_of_variability_of_metformin_pharmacokinetics.pdf

2

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

المساهمون: Epidemiology, Internal Medicine

المصدر: Nature Communications
Nature communications 9 (2018). doi:10.1038/s41467-018-06620-4
info:cnr-pdr/source/autori:Tin A.; Li Y.; Brody J.A.; Nutile T.; Chu A.Y.; Huffman J.E.; Yang Q.; Chen M.-H.; Robinson-Cohen C.; Mace A.; Liu J.; Demirkan A.; Sorice R.; Sedaghat S.; Swen M.; Yu B.; Ghasemi S.; Teumer A.; Vollenweider P.; Ciullo M.; Li M.; Uitterlinden A.G.; Kraaij R.; Amin N.; van Rooij J.; Kutalik Z.; Dehghan A.; McKnight B.; van Duijn C.M.; Morrison A.; Psaty B.M.; Boerwinkle E.; Fox C.S.; Woodward O.M.; Kottgen A./titolo:Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels/doi:10.1038%2Fs41467-018-06620-4/rivista:Nature communications/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9:4228. Nature Publishing Group
Nature communications, vol. 9, no. 1, pp. 4228

مصطلحات موضوعية: 0301 basic medicine, Organic Cation Transport Proteins, Science, Glucose Transport Proteins, Facilitative, General Physics and Astronomy, Organic Anion Transporters, Genome-wide association study, Disease, Bioinformatics, Kidney Function Tests, General Biochemistry, Genetics and Molecular Biology, Article, Protein Structure, Secondary, 03 medical and health sciences, chemistry.chemical_compound, Exome/genetics, Genetic Predisposition to Disease, Glucose Transport Proteins, Facilitative/chemistry, Glucose Transport Proteins, Facilitative/genetics, Glucose Transport Proteins, Facilitative/metabolism, Humans, Meta-Analysis as Topic, Organic Anion Transporters/chemistry, Organic Anion Transporters/genetics, Organic Anion Transporters/metabolism, Organic Cation Transport Proteins/chemistry, Organic Cation Transport Proteins/genetics, Organic Cation Transport Proteins/metabolism, Uric Acid/blood, MD Multidisciplinary, medicine, Exome, lcsh:Science, Exome sequencing, Genetic association, Multidisciplinary, biology, business.industry, Lesinurad, serum urate levels, General Chemistry, medicine.disease, 3. Good health, Gout, Uric Acid, 030104 developmental biology, chemistry, biology.protein, SLC22A12, lcsh:Q, business, SLC2A9

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09617704df3edc2b2becb350d2b1af49
https://doi.org/10.1038/s41467-018-06620-4

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3

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin:A Metgen Meta-Analysis

المساهمون: Epidemiology, Internal Medicine, General practice, APH - Health Behaviors & Chronic Diseases, APH - Methodology

المصدر: Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Hougaard Christensen, M M, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A Metgen Meta-Analysis ', Clinical Pharmacology and Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Blood Glucose, Male, Glycated Hemoglobin A, Databases, Factual, Pharmacogenomic Variants, endocrine system diseases, Octamer Transcription Factor-1/genetics, 80 and over, 2.1 Biological and endogenous factors, Pharmacology & Pharmacy, Membrane Transport Proteins/genetics, Aetiology, Aged, 80 and over, Symporters, Diabetes, digestive, oral, and skin physiology, Organic Cation Transporter 2, Articles, Single Nucleotide, Pharmacology and Pharmaceutical Sciences, Middle Aged, Metformin, Phenotype, Treatment Outcome, Female, Patient Safety, Diabetes Mellitus, Type 2/blood, Type 2, Organic Cation Transport Proteins, Genotype, Glycated Hemoglobin A/metabolism, Hypoglycemic Agents/therapeutic use, and over, Polymorphism, Single Nucleotide, Databases, Blood Glucose/drug effects, Diabetes Mellitus, Genetics, Hypoglycemic Agents, Humans, Metformin/therapeutic use, Polymorphism, Factual, Metabolic and endocrine, Aged, Glycated Hemoglobin, Research, Membrane Transport Proteins, nutritional and metabolic diseases, Diabetes Mellitus, Type 2, Biomarkers, Biomarkers/blood, Octamer Transcription Factor-1, Organic Cation Transport Proteins/genetics