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المؤلفون: Vivien Grant, Dáire Gannon, Eimear Lagan, Neza Alfazema, Craig Monger, Steven M. Pollard, Hannah K. Neikes, Orla Deevy, Darren J. Fitzpatrick, Raul Bardini Bressan, Evan Healy, Maria-Angeles Marqués-Torrejón, Adrian P. Bracken, Anthony M Doherty, Gerard L. Brien
المصدر: Brien, G L, Bressan, R B, Monger, C, Gannon, D, Lagan, E, Doherty, A M, Healy, E, Neikes, H, Fitzpatrick, D J, Deevy, O, Grant, V, Marqués-Torrejón, M-A, Alfazema, N, Pollard, S M & Bracken, A P 2021, ' Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells ', Nature Genetics, vol. 53, no. 8, pp. 1221-1232 . https://doi.org/10.1038/s41588-021-00897-w
مصطلحات موضوعية: biology, glioblastoma, Hindbrain, H3.3, macromolecular substances, PRC2, Neural stem cell, Chromatin, Cell biology, neural stem cell, Histone H3, Histone, Genetics, biology.protein, Enhancer, polycomb, Epigenomics
وصف الملف: application/pdf
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المؤلفون: Gerard L, Brien, Raul Bardini, Bressan, Craig, Monger, Dáire, Gannon, Eimear, Lagan, Anthony M, Doherty, Evan, Healy, Hannah, Neikes, Darren J, Fitzpatrick, Orla, Deevy, Vivien, Grant, Maria-Angeles, Marqués-Torrejón, Neza, Alfazema, Steven M, Pollard, Adrian P, Bracken
المصدر: Nature genetics. 53(8)
مصطلحات موضوعية: Male, Brain Neoplasms, Lysine, Polycomb Repressive Complex 2, Gene Expression Regulation, Developmental, Cell Differentiation, Mice, Inbred Strains, Glioma, Oncogenes, Cell Line, Histones, Rhombencephalon, Epigenome, Enhancer Elements, Genetic, Neural Stem Cells, Mutation, Animals, Humans, Enhancer of Zeste Homolog 2 Protein, Promoter Regions, Genetic
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المؤلفون: Adrian P. Bracken, Orla Deevy
المصدر: Development (Cambridge, England)
مصطلحات موضوعية: Regulator, Embryonic Development, macromolecular substances, Review, Models, Biological, NSD1, Congenital Abnormalities, 03 medical and health sciences, Histone H3, 0302 clinical medicine, Tatton-Brown–Rahman syndrome, Animals, Humans, Molecular Biology, Sotos syndrome, Loss function, 030304 developmental biology, Genetics, Mammals, 0303 health sciences, biology, Polycomb Repressive Complex 2, Methylation, Phenotype, PRC2, Chromatin, Weaver syndrome, biology.protein, DNMT3A, 030217 neurology & neurosurgery, Developmental Biology, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a526bef2b1a100432e283063e5a89036
https://pubmed.ncbi.nlm.nih.gov/31575610 -
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المؤلفون: Christie B. Nguyen, Mary Fowkes, Anqi Ma, Zulekha A. Qadeer, Zhen Sun, Emily Bernstein, David Meni, April Cook, Armita Bahrami, Aroa Soriano, Jian Jin, Asif Chowdhury, Xiang Chen, Fumiko Dekio, Miguel F. Segura, Elizabeth Stewart, Sara M. Federico, Orla Deevy, Stephen S. Roberts, Maged Zeineldin, Luz Jubierre, Michael A. Dyer, Dan Filipescu, Soledad Gallego, William A. Weiss, Nai-Kong V. Cheung, Lyra Griffiths, David Valle-Garcia, Dan Hasson, John M. Maris, David B. Finkelstein
المصدر: Cancer Cell
مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, X-linked Nuclear Protein, Neurogenesis, Biology, Article, Epigenesis, Genetic, Histones, 03 medical and health sciences, Mice, Neuroblastoma, 0302 clinical medicine, Protein Domains, Cell Line, Tumor, medicine, Gene silencing, Animals, Humans, Enhancer of Zeste Homolog 2 Protein, Promoter Regions, Genetic, Gene, ATRX, Sequence Deletion, Neurons, Base Sequence, EZH2, Promoter, Cell Differentiation, medicine.disease, Xenograft Model Antitumor Assays, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, Repressor Proteins, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70680fb31098f387547c6c00ecfc99c2
https://pubmed.ncbi.nlm.nih.gov/31631027 -
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المؤلفون: Evan Healy, Raphaël Margueron, Aoife McLysaght, Haruhiko Koseki, Luciano Di Croce, Darren J. Fitzpatrick, Emilia Jerman, Orla Deevy, Manabu Nakayama, Kieran Wynne, Giorgio Oliviero, Gundula Streubel, Karsten Hokamp, Adrian P. Bracken, Claudio Ciferri, Ariane Watson, Indigo Pratt-Kelly, Christine S. Huang, Paul Chammas, Marlena Mucha, Tomoyuki Ishikura, Eleanor Glancy, Gerard Cagney, Eric Conway, Shinsuke Ito, Alan M. Rice, Daniel Holoch, Yoko Koseki
المصدر: Molecular cell. 70(3)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, macromolecular substances, Biology, Methylation, Cell Line, Histones, 03 medical and health sciences, Histone H3, Mice, Neoplasms, SUZ12, Animals, Humans, RBBP4, Amino Acid Sequence, Molecular Biology, Gene, Genetics, EZH2, Polycomb Repressive Complex 2, Cell Differentiation, Cell Biology, Methyltransferases, Repressor Proteins, 030104 developmental biology, HEK293 Cells, Vertebrates, biology.protein, LCOR, PRC2, Sequence Alignment
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المؤلفون: David Finkelstein, Xiang Chen, Emily Bernstein, Armita Bahrami, Jian Jin, Fumiko Dekio, Elizabeth Stewart, Michael A. Dyer, Asif Chowdhury, Mary Fowkes, Lyra Griffiths, Soledad Gallego, Zhen Sun, Dan Filipescu, Aroa Soriano, Maged Zeineldin, Luz Jubierre, William A. Weiss, Stephen S. Roberts, Nai-Kong V. Cheung, Sara M. Federico, Orla Deevy, Zulekha A. Qadeer, David Meni, David Valle-Garcia, John M. Maris, Miguel F. Segura, Dan Hasson, Anqi Ma
المصدر: Neuro-Oncology. 21:ii81-ii81
مصطلحات موضوعية: Cancer Research, Mutation, Chemistry, EZH2, Genetics/Epigentics, medicine.disease_cause, medicine.disease, Cell biology, Chromatin, Oncology, Neuroblastoma, medicine, Neuron differentiation, Neurology (clinical), Gene, Derepression, ATRX
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5aae9a4cfdc2d8db0981287f569de5
https://doi.org/10.1093/neuonc/noz036.076
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