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المؤلفون: Zhang S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Orozco CC; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Tang LWT; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Racich J; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Carlo AA; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Chang G; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Tess D; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Keefer C; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA., Di L; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, 06340, USA. li.di@Recursionpharma.com.; Recursion Pharmaceuticals, Salt Lake City, Utah, 84101, USA. li.di@Recursionpharma.com.

المصدر: The AAPS journal [AAPS J] 2024 Mar 28; Vol. 26 (3), pp. 38. Date of Electronic Publication: 2024 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

مواضيع طبية MeSH: Liver*/metabolism , Saponins*/pharmacology , Saponins*/metabolism, Humans ; Hepatocytes/metabolism ; Drug Discovery ; Microsomes, Liver

المؤلفون: Filipski KJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Garnsey MR; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Smaltz DJ; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Coffman K; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Futatsugi K; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Lee J; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., O'Neil SV; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Wright A; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Nason D; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Gosset JR; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Orozco CC; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Blackler D; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Fakhoury G; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Gutierrez JA; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Perez S; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ross T; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Stock I; Pfizer Research & Development, 558 Eastern Point Road, Groton, Connecticut 06340, United States., Tesz G; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Dullea R; Pfizer Research & Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Oct 02; Vol. 14 (10), pp. 1427-1433. Date of Electronic Publication: 2023 Oct 02 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Orozco CC; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Neuvonen M; Department of Clinical Pharmacology, University of Helsinki, Helsinki FI-00014, Finland.; Individualized Drug Therapy Research Program, University of Helsinki, Helsinki FI-00014, Finland., Bi YA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Cerny MA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Mathialagan S; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Tylaska L; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Rago B; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Costales C; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., King-Ahmad A; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Niemi M; Department of Clinical Pharmacology, University of Helsinki, Helsinki FI-00014, Finland.; Individualized Drug Therapy Research Program, University of Helsinki, Helsinki FI-00014, Finland.; Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki FI-00029, Finland., Rodrigues AD; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.

المصدر: Molecular pharmaceutics [Mol Pharm] 2023 Jun 05; Vol. 20 (6), pp. 3020-3032. Date of Electronic Publication: 2023 May 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transporters*/genetics , Organic Anion Transporters*/metabolism, Humans ; Sulfates ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism ; Liver-Specific Organic Anion Transporter 1/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Bile Acids and Salts ; Biological Transport/physiology ; Biomarkers/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism

المؤلفون: Lapham K; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.) kimberly.lapham@pfizer.com., Callegari E; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Cianfrogna J; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Lin J; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Niosi M; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Orozco CC; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Sharma R; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.)., Goosen TC; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., E.C., J.L., M.N., C.C.O., R.S., T.C.G.) and Pfizer Inc., La Jolla, California (J.C.).

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2020 Dec; Vol. 48 (12), pp. 1350-1363. Date of Electronic Publication: 2020 Oct 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic/*pharmacokinetics , Cytochrome P-450 Enzyme System/*metabolism , Glucuronosyltransferase/*metabolism, Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Drug Interactions ; Enzyme Assays ; Glucuronosyltransferase/antagonists & inhibitors ; Hepatobiliary Elimination/drug effects ; Humans ; Microsomes, Liver ; Recombinant Proteins/metabolism

المؤلفون: Orozco CC; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Atkinson K; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Ryu S; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Chang G; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Keefer C; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Lin J; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Riccardi K; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Mongillo RK; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Tess D; Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA., Filipski KJ; Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA., Kalgutkar AS; Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA., Litchfield J; Medicine Design, Pfizer Worldwide Research & Development, Cambridge, MA, USA., Scott D; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA., Di L; Medicine Design, Pfizer Worldwide Research & Development, Groton, CT, USA. Electronic address: li.di@pfizer.com.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Jan 01; Vol. 185, pp. 111813. Date of Electronic Publication: 2019 Oct 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Organic Chemicals/*pharmacokinetics , Pharmaceutical Preparations/*chemistry, Animals ; Dose-Response Relationship, Drug ; Infusions, Intravenous ; Male ; Models, Molecular ; Molecular Structure ; Organic Chemicals/administration & dosage ; Organic Chemicals/chemistry ; Pharmaceutical Preparations/administration & dosage ; Rats ; Rats, Wistar ; Structure-Activity Relationship ; Tissue Distribution

المؤلفون: Davoren JE, Nason D; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Coe J; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Dlugolenski K, Helal C; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Harris AR; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., LaChapelle E; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Liang S; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Liu Y, O'Connor R; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Orozco CC; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Rai BK, Salafia M; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Samas B; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Xu W; Medicine Design , Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States., Kozak R, Gray D

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11384-11397. Date of Electronic Publication: 2018 Dec 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dopamine Agonists/*chemistry , Dopamine Agonists/*pharmacology , Receptors, Dopamine D1/*agonists, Animals ; Biological Availability ; CHO Cells ; Cricetulus ; Cyclic AMP/metabolism ; Dogs ; Dopamine Agonists/adverse effects ; Dose-Response Relationship, Drug ; HEK293 Cells ; Half-Life ; High-Throughput Screening Assays/methods ; Humans ; Madin Darby Canine Kidney Cells ; Male ; Mice, Inbred Strains ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Receptors, Dopamine D1/metabolism ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Ballard TE; Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut., Orozco CC, Obach RS

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2014 May; Vol. 42 (5), pp. 899-902. Date of Electronic Publication: 2014 Mar 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Hepatocytes/*metabolism , Pharmaceutical Preparations/*metabolism, Cells, Cultured ; Chromatography, High Pressure Liquid ; Coculture Techniques ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Humans ; Metabolic Detoxication, Phase I ; Metabolic Detoxication, Phase II ; Pharmaceutical Preparations/chemistry ; Tandem Mass Spectrometry