المؤلفون: Overwater IE, Rietman AB, van Eeghen AM, de Wit MCY

المصدر: Therapeutics and Clinical Risk Management, Vol Volume 15, Pp 951-955 (2019)

مصطلحات موضوعية: mTOR, epileptogenesis, epilepsy, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.dovepress.com/everolimus-for-the-treatment-of-refractory-seizures-associated-with-tu-peer-reviewed-article-TCRM; https://doaj.org/toc/1178-203X

URL الوصول: https://doaj.org/article/fd8902b1515e4659b9774195ac1ebb71

المؤلفون: Overwater, IE, Rietman, A, Bindels-de Heus, GCB, Moll, HA, Elgersma, Y, Wit, MCY

المصدر: European Journal of Paediatric Neurology; Sep2013 Supplement, Vol. 17, pS14-S15, 0p

المؤلفون: Hulshof HM; Department of Paediatric Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands. Electronic address: h.m.hulshof-4@umcutrecht.nl., Brenner J; Department of Paediatric Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands., Overwater IE; Department of Paediatric Neurology, Erasmus Medical Center Rotterdam, the Netherlands., Wit MC; Department of Paediatric Neurology, Erasmus Medical Center Rotterdam, the Netherlands., Braun KPJ; Department of Paediatric Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands., Jansen FE; Department of Paediatric Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands.

المصدر: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2020 Mar; Vol. 25, pp. 113-119. Date of Electronic Publication: 2020 Jan 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Saunders Country of Publication: England NLM ID: 9715169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2130 (Electronic) Linking ISSN: 10903798 NLM ISO Abbreviation: Eur J Paediatr Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Tuberous Sclerosis*, Counseling/*methods , Parents/*education, Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Male ; Netherlands ; Parents/psychology ; Quality of Life ; Surveys and Questionnaires

المؤلفون: Overwater IE; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Rietman AB; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Mous SE; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Bindels-de Heus K; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Rizopoulos D; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Ten Hoopen LW; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., van der Vaart T; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Jansen FE; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Elgersma Y; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands. m.c.y.dewit@erasmusmc.nl h.a.moll@erasmusmc.nl y.elgersma@erasmusmc.nl., Moll HA; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands. m.c.y.dewit@erasmusmc.nl h.a.moll@erasmusmc.nl y.elgersma@erasmusmc.nl., de Wit MY; From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands. m.c.y.dewit@erasmusmc.nl h.a.moll@erasmusmc.nl y.elgersma@erasmusmc.nl.

مؤلفون مشاركون: ENCORE Expertise Centre for Neurodevelopmental Disorders

المصدر: Neurology [Neurology] 2019 Jul 09; Vol. 93 (2), pp. e200-e209. Date of Electronic Publication: 2019 Jun 19.

نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE

مواضيع طبية MeSH: Autistic Disorder/*drug therapy , Everolimus/*therapeutic use , Immunosuppressive Agents/*therapeutic use , Intellectual Disability/*drug therapy , TOR Serine-Threonine Kinases/*antagonists & inhibitors , Tuberous Sclerosis/*drug therapy, Adolescent ; Autistic Disorder/etiology ; Autistic Disorder/psychology ; Child ; Communication ; Double-Blind Method ; Executive Function ; Female ; Humans ; Intellectual Disability/etiology ; Intelligence Tests ; Male ; Problem Behavior ; Quality of Life ; Sleep ; Social Behavior ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/psychology

المؤلفون: Mous SE; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands. s.mous@erasmusmc.nl.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands. s.mous@erasmusmc.nl., Overwater IE; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.; Department of Pediatric Neurology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands., Vidal Gato R; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands., Duvekot J; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands., Ten Hoopen LW; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands., Lequin MH; Department of Radiology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands., de Wit MY; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.; Department of Pediatric Neurology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands., Dieleman GC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center-Sophia Children's Hospital, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands.

المصدر: European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2018 Jun; Vol. 27 (6), pp. 753-765. Date of Electronic Publication: 2017 Oct 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Country of Publication: Germany NLM ID: 9212296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-165X (Electronic) Linking ISSN: 10188827 NLM ISO Abbreviation: Eur Child Adolesc Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Autism Spectrum Disorder/*epidemiology , Autistic Disorder/*diagnosis , Autistic Disorder/*etiology , Cognition/*physiology , Malformations of Cortical Development/*epidemiology , Tuberous Sclerosis/*complications, Adolescent ; Autistic Disorder/complications ; Child ; Child, Preschool ; Epidemiologic Studies ; Female ; Humans ; Male ; Phenotype ; Severity of Illness Index

المؤلفون: de Wit MY; Rotterdam, Netherlands., Overwater IE; Rotterdam, Netherlands.

المصدر: Neurology [Neurology] 2017 Mar 07; Vol. 88 (10), pp. 1008.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE

مواضيع طبية MeSH: Epilepsy* , Tuberous Sclerosis*, Child ; Humans ; Sirolimus ; TOR Serine-Threonine Kinases

المؤلفون: Overwater IE; Department of Neurology, Erasmus University Medical Centre, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Verhaar BJ; Department of Neurology, Erasmus University Medical Centre, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Lingsma HF; Department of Public Health, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Bindels-de Heus GC; Department of Pediatrics, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., van den Ouweland AM; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Nellist M; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Ten Hoopen LW; Department of Child and Adolescent Psychiatry, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Elgersma Y; Department of Neuroscience, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., Moll HA; Department of Pediatrics, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands., de Wit MC; Department of Neurology, Erasmus University Medical Centre, PO Box 2060, 3000 CB, Rotterdam, The Netherlands. m.c.y.dewit@erasmusmc.nl.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, PO Box 2060, 3000 CB, Rotterdam, The Netherlands. m.c.y.dewit@erasmusmc.nl.

المصدر: Journal of neurology [J Neurol] 2017 Jan; Vol. 264 (1), pp. 161-167. Date of Electronic Publication: 2016 Nov 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Cognition* , Intelligence*, Tuberous Sclerosis/*diagnosis , Tuberous Sclerosis/*psychology, Age of Onset ; Child ; Child Development ; Child, Preschool ; Epilepsy/diagnosis ; Epilepsy/epidemiology ; Epilepsy/psychology ; Epilepsy/therapy ; Female ; Follow-Up Studies ; Humans ; Intellectual Disability/diagnosis ; Intellectual Disability/epidemiology ; Intellectual Disability/genetics ; Intelligence Tests ; Male ; Multivariate Analysis ; Prognosis ; Psychology, Child ; Regression Analysis ; Retrospective Studies ; Tuberous Sclerosis/epidemiology ; Tuberous Sclerosis/therapy

المؤلفون: Overwater IE; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.; ENCORE-TSC Expertise Center, Erasmus Medical Center, Rotterdam, The Netherlands., Swenker R; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., van der Ende EL; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Hanemaayer KB; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Hoogeveen-Westerveld M; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., van Eeghen AM; ENCORE-TSC Expertise Center, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands., Lequin MH; Department of Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands., van den Ouweland AM; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Moll HA; ENCORE-TSC Expertise Center, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands., Nellist M; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., de Wit MY; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.; ENCORE-TSC Expertise Center, Erasmus Medical Center, Rotterdam, The Netherlands.

المصدر: European journal of human genetics : EJHG [Eur J Hum Genet] 2016 Dec; Vol. 24 (12), pp. 1688-1695. Date of Electronic Publication: 2016 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genotype* , Phenotype*, Brain/*diagnostic imaging , Tuberous Sclerosis/*genetics, Adolescent ; Child ; Child, Preschool ; Female ; HEK293 Cells ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Mutation ; Tuberous Sclerosis/diagnosis ; Tuberous Sclerosis Complex 1 Protein ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism

المؤلفون: Overwater IE; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Rietman AB; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Bindels-de Heus K; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Looman CW; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Rizopoulos D; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Sibindi TM; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Cherian PJ; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Jansen FE; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Moll HA; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands., Elgersma Y; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands. m.c.y.dewit@erasmusmc.nl y.elgersma@erasmusmc.nl., de Wit MC; From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands. m.c.y.dewit@erasmusmc.nl y.elgersma@erasmusmc.nl.

المصدر: Neurology [Neurology] 2016 Sep 06; Vol. 87 (10), pp. 1011-8. Date of Electronic Publication: 2016 Aug 10.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE

مواضيع طبية MeSH: Anticonvulsants/*therapeutic use , Drug Resistant Epilepsy/*complications , Drug Resistant Epilepsy/*drug therapy , Sirolimus/*therapeutic use , Tuberous Sclerosis/*complications , Tuberous Sclerosis/*drug therapy, Anticonvulsants/adverse effects ; Anticonvulsants/blood ; Child ; Child, Preschool ; Cross-Over Studies ; Drug Resistant Epilepsy/blood ; Drug Resistant Epilepsy/genetics ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Mechanistic Target of Rapamycin Complex 1 ; Multiprotein Complexes/antagonists & inhibitors ; Neuropsychological Tests ; Sirolimus/adverse effects ; Sirolimus/blood ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Treatment Outcome ; Tuberous Sclerosis/blood ; Tuberous Sclerosis/genetics

المؤلفون: van der Vaart T; Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, the Netherlands2Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands3ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC., Overwater IE; ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC, University Medical Center, Rotterdam, the Netherlands4Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Oostenbrink R; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands3ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Moll HA; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands3ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Elgersma Y; Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, the Netherlands3ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

المصدر: JAMA neurology [JAMA Neurol] 2015 Sep; Vol. 72 (9), pp. 1052-60.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review; Systematic Review

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Clinical Trials as Topic* , Cognition Disorders*/diet therapy , Cognition Disorders*/drug therapy , Cognition Disorders*/etiology, Genetic Diseases, Inborn/*complications, Humans