المؤلفون: Cannalire R; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Tarantino D; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy; CNR-IBF, Consiglio Nazionale delle Ricerche, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy., Piorkowski G; UMR 'Emergence des Pathologies Virales' (Aix-Marseille University - IRD 190 - Inserm 1207 - EHESP), Fondation IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Faculté de Médecine, 27 bd Jean Moulin, 13005 Marseille, France., Carletti T; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Padriciano 99 - 34149, Trieste, Italy., Massari S; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Felicetti T; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Barreca ML; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Sabatini S; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Tabarrini O; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Marcello A; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), AREA Science Park, Padriciano 99 - 34149, Trieste, Italy., Milani M; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy; CNR-IBF, Consiglio Nazionale delle Ricerche, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy., Cecchetti V; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy., Mastrangelo E; Dipartimento di Bioscienze, Università di Milano, Via Celoria 26, I-20133, Milano, Italy; CNR-IBF, Consiglio Nazionale delle Ricerche, Istituto di Biofisica, Via Celoria 26, I-20133, Milano, Italy. Electronic address: eloise.mastrangelo@unimi.it., Manfroni G; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1-06123, Perugia, Italy. Electronic address: giuseppe.manfroni@unipg.it., Querat G; UMR 'Emergence des Pathologies Virales' (Aix-Marseille University - IRD 190 - Inserm 1207 - EHESP), Fondation IHU Méditerranée Infection, APHM Public Hospitals of Marseille, Faculté de Médecine, 27 bd Jean Moulin, 13005 Marseille, France. Electronic address: gilles.querat@univ-amu.fr.

المصدر: Antiviral research [Antiviral Res] 2019 Jul; Vol. 167, pp. 6-12. Date of Electronic Publication: 2019 Mar 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/chemical synthesis , Antiviral Agents*/pharmacology , Oxazocines*/chemical synthesis , Oxazocines*/pharmacology , Pyridines*/chemical synthesis , Pyridines*/pharmacology, Flaviviridae/*drug effects, Animals ; Dengue Virus/drug effects ; Encephalitis Viruses, Tick-Borne/drug effects ; Humans ; RNA, Viral/drug effects ; Virion/drug effects ; Virus Replication/drug effects ; West Nile virus/drug effects ; Yellow fever virus/drug effects ; Zika Virus/drug effects

المؤلفون: Sastry KN; Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad-500037, India., Routhu SR; Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India and Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, India., Datta SG; Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India and Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, India., Nagesh N; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India., Babu BN; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad-500037, India., Nanubolu JB; Centre for X-Ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India., Kumar CG; Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India., Maurya RA; Applied Organic Chemistry Group, Chemical Science & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam-785006, India. ram.cdri@gmail.com ahmedkamal@iict.res.in nagesh@ccmb.res.in., Kamal A; Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India and Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad-500037, India.

المصدر: Organic & biomolecular chemistry [Org Biomol Chem] 2016 Oct 04; Vol. 14 (39), pp. 9294-9305.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Antineoplastic Agents/*pharmacology , DNA/*metabolism , Oxazocines/*chemistry, Antineoplastic Agents/metabolism ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; HeLa Cells ; Humans ; MCF-7 Cells ; Oxazocines/pharmacology ; Spectrophotometry, Ultraviolet ; Structure-Activity Relationship ; Viscosity

المؤلفون: Scully SS; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States., Zheng SL, Wagner BK, Schreiber SL

المصدر: Organic letters [Org Lett] 2015 Feb 06; Vol. 17 (3), pp. 418-21. Date of Electronic Publication: 2015 Jan 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

مواضيع طبية MeSH: Alkynes/*chemistry , Amides/*chemistry , Gold/*chemistry , Oxazocines/*chemical synthesis, Aldehydes ; Catalysis ; Cyclization ; Molecular Structure ; Oxazocines/chemistry ; Stereoisomerism

المؤلفون: Rastorgueva, Maria S., Weber, Danil I., Sapegin, Alexander V.^{Aff1, IDs10593023032552_cor3}

المصدر: Chemistry of Heterocyclic Compounds. 59(9-10):692-697

المؤلفون: Rao AU; Department of Medicinal Chemistry, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ashwin.rao@merck.com, Xiao D, Huang X, Zhou W, Fossetta J, Lundell D, Tian F, Trivedi P, Aslanian R, Palani A

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 15; Vol. 22 (2), pp. 1068-72. Date of Electronic Publication: 2011 Dec 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Azepines/*pharmacology , Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors , Oxazocines/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Protein Serine-Threonine Kinases/*antagonists & inhibitors, Azepines/chemical synthesis ; Azepines/chemistry ; Humans ; Molecular Structure ; Oxazocines/chemical synthesis ; Oxazocines/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Mitra S; Chemistry Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, India., Banerjee TS, Hota SK, Bhattacharya D, Das S, Chattopadhyay P

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2011 May; Vol. 46 (5), pp. 1713-20. Date of Electronic Publication: 2011 Feb 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Oxazocines/*pharmacology , Receptors, Opioid, kappa/*agonists, Amination ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Binding Sites/drug effects ; Catalysis ; Cell Proliferation/drug effects ; Glioma/enzymology ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Molecular Structure ; Oxazocines/chemical synthesis ; Oxazocines/chemistry ; Palladium/chemistry ; Stereoisomerism ; Structure-Activity Relationship ; Tumor Cells, Cultured

المؤلفون: Narjes F; Istituto Di Ricerche Di Biologia Molecolare, P. Angeletti SpA (Merck Research Laboratories, Rome), Pomezia, Italy. Frank.Narjes@astrazeneca.com, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M

المصدر: Journal of medicinal chemistry [J Med Chem] 2011 Jan 13; Vol. 54 (1), pp. 289-301. Date of Electronic Publication: 2010 Dec 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*chemical synthesis , Hepacivirus/*drug effects , Indoles/*chemical synthesis , Oxazocines/*chemical synthesis , RNA-Dependent RNA Polymerase/*antagonists & inhibitors , Viral Nonstructural Proteins/*antagonists & inhibitors, Administration, Oral ; Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Biological Availability ; Cell Line, Tumor ; Crystallography, X-Ray ; Dogs ; Hepacivirus/enzymology ; Hepacivirus/physiology ; Humans ; Indoles/pharmacokinetics ; Indoles/pharmacology ; Macaca mulatta ; Mice ; Mice, SCID ; Mice, Transgenic ; Models, Molecular ; Molecular Structure ; Oxazocines/pharmacokinetics ; Oxazocines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Structure-Activity Relationship ; Viremia/drug therapy ; Viremia/virology ; Virus Replication/drug effects

المؤلفون: Janković N; Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia. Electronic address: nenad.jankovic@kg.ac.rs., Trifunović Ristovski J; Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia., Vraneš M; Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia., Tot A; Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia., Petronijević J; Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia., Joksimović N; Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia., Stanojković T; Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia., Đorđić Crnogorac M; Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia., Petrović N; Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia; Vinča Institute of Nuclear Science, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia., Boljević I; Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia., Matić IZ; Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia., Bogdanović GA; Vinča Institute of Nuclear Science, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia., Mikov M; Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia., Bugarčić Z; Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.

المصدر: Bioorganic chemistry [Bioorg Chem] 2019 May; Vol. 86, pp. 569-582. Date of Electronic Publication: 2019 Feb 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Molecular Docking Simulation*, Antineoplastic Agents, Phytogenic/*pharmacology , Apoptosis/*drug effects , Caspase 9/*metabolism , MicroRNAs/*antagonists & inhibitors , Neovascularization, Pathologic/*drug therapy, A549 Cells ; Aldehydes/chemical synthesis ; Aldehydes/chemistry ; Aldehydes/pharmacology ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents, Phytogenic/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Cisplatin/chemistry ; Cisplatin/pharmacology ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; MicroRNAs/genetics ; Molecular Structure ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Oxazocines/chemical synthesis ; Oxazocines/chemistry ; Oxazocines/pharmacology ; Pyrimidinones/chemical synthesis ; Pyrimidinones/chemistry ; Pyrimidinones/pharmacology ; Structure-Activity Relationship

المؤلفون: Seto S; Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. shigeki.seto@mb.kyorin-pharm.co.jp, Tanioka A, Ikeda M, Izawa S

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2005 Oct 15; Vol. 13 (20), pp. 5717-32.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Neurokinin-1 Receptor Antagonists*, Oxazocines/*chemical synthesis , Oxazocines/*pharmacology, Animals ; Drug Evaluation, Preclinical ; Guinea Pigs ; Magnetic Resonance Spectroscopy ; Muscle Contraction/drug effects ; Oxazocines/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Urinary Bladder/drug effects ; Urinary Bladder/physiology

المؤلفون: Seto S; Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. shigeki.seto@mb.kyorin-pharm.co.jp, Tanioka A, Ikeda M, Izawa S

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Mar 01; Vol. 15 (5), pp. 1485-8.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Neurokinin-1 Receptor Antagonists*, Heterocyclic Compounds/*chemical synthesis , Heterocyclic Compounds/*pharmacology , Oxazocines/*chemical synthesis , Oxazocines/*pharmacology, Animals ; Drug Evaluation, Preclinical ; Guinea Pigs ; Heterocyclic Compounds/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Oxazocines/chemistry ; Structure-Activity Relationship ; Urinary Bladder/drug effects ; Urinary Bladder/physiology