نتائج البحث - "PI3K/mTOR Inhibitor BEZ235"

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Resistance of hepatocellular carcinoma to sorafenib can be overcome with co-delivery of PI3K/mTOR inhibitor BEZ235 and sorafenib in nanoparticles

المؤلفون: Huaiyong Gan, Xueke Liu, Shuping Zhou, Amin Li, Xiaolong Tang, Shiyu Cai, Binquan Wu, Yinci Zhang, Yong Liang

المصدر: Expert Opinion on Drug Delivery. 17:573-587

مصطلحات موضوعية: Sorafenib, Drug, Carcinoma, Hepatocellular, Polyesters, media_common.quotation_subject, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, 02 engineering and technology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Animals, Humans, Vitamin E, Phosphoinositide-3 Kinase Inhibitors, media_common, Drug Carriers, Mice, Inbred BALB C, Chemistry, TOR Serine-Threonine Kinases, Liver Neoplasms, Imidazoles, technology, industry, and agriculture, Hep G2 Cells, 021001 nanoscience & nanotechnology, medicine.disease, In vitro, Bioavailability, Drug Combinations, PI3K/mTOR Inhibitor BEZ235, Hepatocellular carcinoma, Quinolines, Cancer research, Nanoparticles, Female, 0210 nano-technology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574256dde6d152cd050efe5dadc43d68
https://doi.org/10.1080/17425247.2020.1730809

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2

The anti-tumor effects of dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A on inducing autophagy in esophageal squamous cell carcinoma

المؤلفون: Yang Song, Xiao Xu, Ning Wu, Yingfeng Zhu, Zhiming Chen, Liewen Pang, Yongjun Zhu

المصدر: Journal of Cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53be83c01a4b0073f2829026487c6218
https://doi.org/10.7150/jca.22861

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The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens

المؤلفون: Jia En Wu, Shuenn Chen Yang, Kuo Yen Huang, Tse-Ming Hong, Keng Fu Hsu, Chao Jung Tsao, Si Xuan Chen, Yi Ying Wu, Yuh Ling Chen, Hung Chang Wu

المصدر: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Lung Neoplasms, Afatinib, medicine.medical_treatment, Apoptosis, medicine.disease_cause, Targeted therapy, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Medicine, Cyclin D1, Epidermal growth factor receptor, Cyclin D3, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, TOR Serine-Threonine Kinases, Imidazoles, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ErbB Receptors, Oncology, 030220 oncology & carcinogenesis, Quinolines, Lung cancer, medicine.drug, Signal Transduction, EGFR, Mice, Nude, lcsh:RC254-282, 03 medical and health sciences, Animals, Humans, PI3K/AKT/mTOR pathway, business.industry, Research, Cell Cycle Checkpoints, BEZ235, medicine.disease, respiratory tract diseases, PI3K/mTOR, 030104 developmental biology, PI3K/mTOR Inhibitor BEZ235, Tumor progression, A549 Cells, Drug Resistance, Neoplasm, Cancer research, biology.protein, Cisplatin, business, Carcinogenesis, Combined therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923dbdf487f1a585054acaf031d1c540
http://europepmc.org/articles/PMC6604380

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4

HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

المؤلفون: Biao Duan, Jie Cui, Yan Chen, Jianchao Zheng, Yongchang Chen, Bixing Ye, Shixiu Sun, Lei Liu, Wenjie Deng, Yujie Zhang, Jun Du, Luo Gu

المصدر: Cell Death and Disease, Vol 9, Iss 9, Pp 1-13 (2018)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c2bb4247ef5548bc8d1c2f0c29767b
https://doi.org/10.1038/s41419-018-0931-0

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5

Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells

المؤلفون: Hyunchul Cho, Yonghoon Lee, Iljoong Oh, Deok-Bae Park, Minseok Cheon, Youngki Lee

المصدر: Development & Reproduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812098f299ea6180817d1f82a7745ee5
https://doi.org/10.12717/dr.2016.20.1.001

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Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235

المؤلفون: Min H. Kang, C. Patrick Reynolds, Connor P. Hall

المصدر: Clinical Cancer Research. 22:621-632

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cell Survival, AKT1, Antineoplastic Agents, Apoptosis, Pharmacology, Biology, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Dexamethasone, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, Humans, Glucocorticoids, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Bcl-2-Like Protein 11, TOR Serine-Threonine Kinases, RPTOR, Imidazoles, Membrane Proteins, Drug Synergism, Xenograft Model Antitumor Assays, Tumor Burden, Gene Expression Regulation, Neoplastic, Disease Models, Animal, 030104 developmental biology, PI3K/mTOR Inhibitor BEZ235, Oncology, Mechanism of action, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Quinolines, Myeloid Cell Leukemia Sequence 1 Protein, Female, medicine.symptom, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20a10e36da6c2eeb4286179ee3133e1
https://doi.org/10.1158/1078-0432.ccr-15-0114

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Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway

المؤلفون: Lin Shen, Zhongwu Li, Xiaoting Lin, Zuhua Chen, Beifang Li, Zhentao Liu, Dongshao Chen, Jingyuan Wang, Xiaotian Zhang, Cheng Zhang, Jing Gao, Jiafu Ji, Bin Dong, Yanting Hu

المصدر: Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-11 (2018)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Epithelial-Mesenchymal Transition, Paclitaxel, Immunology, Mice, Nude, Antineoplastic Agents, Apoptosis, Antimitotic Agents, Microtubules, Article, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Stomach Neoplasms, Cell Line, Tumor, medicine, Animals, Humans, lcsh:QH573-671, Protein kinase A, Cell Shape, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, Everolimus, lcsh:Cytology, Kinase, Chemistry, TOR Serine-Threonine Kinases, Imidazoles, Cell Biology, 030104 developmental biology, PI3K/mTOR Inhibitor BEZ235, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Quinolines, Cancer research, Female, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489bbfa5e39be5ba84cdbabdc1565637
https://doi.org/10.1038/s41419-017-0132-2

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8

A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors

المؤلفون: L Finney, Johanna C. Bendell, Jeffrey R. Infante, Kent C. Shih, Carla Kurkjian, Howard A. Burris, Todd M. Bauer, Cassie M. Lane, Suzanne F. Jones, F. Anthony Greco, D. S. Thompson

المصدر: Investigational New Drugs. 33:463-471

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928aaf34cbc9fc1524feb8162c8de568
https://doi.org/10.1007/s10637-015-0218-6

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9

Radiosensitization of prostate cancer cells by the dual PI3K/mTOR inhibitor BEZ235 under normoxic and hypoxic conditions

المؤلفون: Eric Giang, Emmanuelle di Tomaso, Stéphane Supiot, Sauveur-Michel Maira, François Paris, Rym Abderrhamani, Vincent Potiron, Sophie Chiavassa

المصدر: Radiotherapy and Oncology. 106:138-146

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c164f8ffcb27191860cce8a93716825
https://doi.org/10.1016/j.radonc.2012.11.014

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10

Abstract P6-10-05: SU2C Phase 1b Trial of Dual PI3K/ mTOR Inhibitor BEZ235 with Letrozole in ER+/HER2− Metastatic Breast Cancer (MBC)

المؤلفون: Vandana G. Abramson, Maria G. Kuba, Ingrid A. Mayer, CL Arteaga, Yufeng Li, Andres Forero, Justin M. Balko, EP Winer, Melinda E. Sanders, Steven J. Isakoff

المصدر: Cancer Research. 72:P6-10

مصطلحات موضوعية: Oncology, Gynecology, Cancer Research, medicine.medical_specialty, business.industry, Letrozole, Cancer, medicine.disease, Metastatic breast cancer, PI3K/mTOR Inhibitor BEZ235, Tolerability, Internal medicine, Cohort, Toxicity, medicine, Mucositis, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::42bd66a3d37ef93d6b0282d4580b397f
https://doi.org/10.1158/0008-5472.sabcs12-p6-10-05

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