المؤلفون: Chen, Hao, King, Frederick, Zhou, Bin, Wang, Yu, Canedy, Carter, Hayashi, Joel, Zhong, Yang, Chang, Max, Pache, Lars, Wong, Julian, Jia, Yong, Joslin, John, Chanda, Sumit, Zhou, Yingyao, Jiang, Tao, Benner, Christopher

المصدر: Nature Communications. 15(1)

مصطلحات موضوعية: Humans, Deep Learning, Machine Learning, Computational Biology, Drug Development

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9d4967pm

المؤلفون: Haas, Kelsey M, McGregor, Michael J, Bouhaddou, Mehdi, Polacco, Benjamin J, Kim, Eun-Young, Nguyen, Thong T, Newton, Billy W, Urbanowski, Matthew, Kim, Heejin, Williams, Michael AP, Rezelj, Veronica V, Hardy, Alexandra, Fossati, Andrea, Stevenson, Erica J, Sukerman, Ellie, Kim, Tiffany, Penugonda, Sudhir, Moreno, Elena, Braberg, Hannes, Zhou, Yuan, Metreveli, Giorgi, Harjai, Bhavya, Tummino, Tia A, Melnyk, James E, Soucheray, Margaret, Batra, Jyoti, Pache, Lars, Martin-Sancho, Laura, Carlson-Stevermer, Jared, Jureka, Alexander S, Basler, Christopher F, Shokat, Kevan M, Shoichet, Brian K, Shriver, Leah P, Johnson, Jeffrey R, Shaw, Megan L, Chanda, Sumit K, Roden, Dan M, Carter, Tonia C, Kottyan, Leah C, Chisholm, Rex L, Pacheco, Jennifer A, Smith, Maureen E, Schrodi, Steven J, Albrecht, Randy A, Vignuzzi, Marco, Zuliani-Alvarez, Lorena, Swaney, Danielle L, Eckhardt, Manon, Wolinsky, Steven M, White, Kris M, Hultquist, Judd F, Kaake, Robyn M, García-Sastre, Adolfo, Krogan, Nevan J

المصدر: Nature Communications. 14(1)

مصطلحات موضوعية: Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Infectious Diseases, Prevention, Emerging Infectious Diseases, Vaccine Related, Influenza, Pneumonia & Influenza, Biodefense, Biotechnology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Infection, Humans, Influenza A virus, Influenza, Human, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H3N2 Subtype, Proteomics, Virus Replication, COVID-19, SARS-CoV-2, Antiviral Agents, Host-Pathogen Interactions

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5h41d3sv

المؤلفون: Tsueng, Ginger^{Aff1, IDs41597023019689_cor1}, Cano, Marco A. Alvarado, Bento, José, Czech, Candice, Kang, Mengjia, Pache, Lars, Rasmussen, Luke V., Savidge, Tor C., Starren, Justin, Wu, Qinglong, Xin, Jiwen, Yeaman, Michael R.^{Aff7, Aff8, Aff9}, Zhou, Xinghua, Su, Andrew I.^{Aff1, Aff10, Aff11}, Wu, Chunlei^{Aff1, Aff10, Aff11}, Brown, Liliana, Shabman, Reed S., Hughes, Laura D.^{Aff1, IDs41597023019689_cor18}

المصدر: Scientific Data. 10(1)

المؤلفون: Hughes, Laura D.^{Aff1, IDs41597023019698_cor1}, Tsueng, Ginger, DiGiovanna, Jack, Horvath, Thomas D.^{Aff3, Aff4}, Rasmussen, Luke V., Savidge, Tor C.^{Aff3, Aff6}, Stoeger, Thomas, Turkarslan, Serdar, Wu, Qinglong^{Aff3, Aff6}, Wu, Chunlei^{Aff1, Aff9, Aff10}, Su, Andrew I.^{Aff1, Aff9, Aff10}, Pache, Lars

المصدر: Scientific Data. 10(1)

المؤلفون: Martin-Sancho, Laura, Tripathi, Shashank, Rodriguez-Frandsen, Ariel, Pache, Lars, Sanchez-Aparicio, Maite, McGregor, Michael J, Haas, Kelsey M, Swaney, Danielle L, Nguyen, Thong T, Mamede, João I, Churas, Christopher, Pratt, Dexter, Rosenthal, Sara B, Riva, Laura, Nguyen, Courtney, Beltran-Raygoza, Nish, Soonthornvacharin, Stephen, Wang, Guojun, Jimenez-Morales, David, De Jesus, Paul D, Moulton, Hong M, Stein, David A, Chang, Max W, Benner, Chris, Ideker, Trey, Albrecht, Randy A, Hultquist, Judd F, Krogan, Nevan J, García-Sastre, Adolfo, Chanda, Sumit K

المصدر: Nature Microbiology. 6(10)

مصطلحات موضوعية: Microbiology, Biochemistry and Cell Biology, Biological Sciences, Biodefense, Vaccine Related, Prevention, Influenza, Emerging Infectious Diseases, Infectious Diseases, Pneumonia & Influenza, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Aetiology, Infection, Antiviral Agents, Autophagy, GTPase-Activating Proteins, Host-Pathogen Interactions, Humans, Immune Evasion, Influenza A virus, Lysosomes, Protein Binding, Viral Matrix Proteins, Virus Replication, rab GTP-Binding Proteins, rab7 GTP-Binding Proteins, Medical Microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9mc7n37n

المؤلفون: Martin-Sancho, Laura, Lewinski, Mary K, Pache, Lars, Stoneham, Charlotte A, Yin, Xin, Becker, Mark E, Pratt, Dexter, Churas, Christopher, Rosenthal, Sara B, Liu, Sophie, Weston, Stuart, De Jesus, Paul D, O'Neill, Alan M, Gounder, Anshu P, Nguyen, Courtney, Pu, Yuan, Curry, Heather M, Oom, Aaron L, Miorin, Lisa, Rodriguez-Frandsen, Ariel, Zheng, Fan, Wu, Chunxiang, Xiong, Yong, Urbanowski, Matthew, Shaw, Megan L, Chang, Max W, Benner, Christopher, Hope, Thomas J, Frieman, Matthew B, García-Sastre, Adolfo, Ideker, Trey, Hultquist, Judd F, Guatelli, John, Chanda, Sumit K

المصدر: Molecular Cell. 81(12)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Vaccine Related, Lung, Pneumonia, Infectious Diseases, Biodefense, Pneumonia & Influenza, Prevention, Genetics, Emerging Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Animals, Antigens, CD, Binding Sites, Cell Line, Tumor, Chlorocebus aethiops, Endoplasmic Reticulum, GPI-Linked Proteins, Gene Expression Regulation, Golgi Apparatus, HEK293 Cells, Host-Pathogen Interactions, Humans, Immunity, Innate, Interferon Regulatory Factors, Interferon Type I, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, SARS-CoV-2, Signal Transduction, Vero Cells, Viral Proteins, Virus Internalization, Virus Release, Virus Replication, BST2, ISG, Orf7a, innate immunity, interferon, viral evasion, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/44n6295p

المؤلفون: Stoneham, Charlotte A, Langer, Simon, De Jesus, Paul D, Wozniak, Jacob M, Lapek, John, Deerinck, Thomas, Thor, Andrea, Pache, Lars, Chanda, Sumit K, Gonzalez, David J, Ellisman, Mark, Guatelli, John

المصدر: PLOS Pathogens. 17(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Endosomal Sorting Complexes Required for Transport, HIV Infections, HIV-1, HeLa Cells, Human Immunodeficiency Virus Proteins, Humans, Microscopy, Electron, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Transport, Protein Tyrosine Phosphatases, Non-Receptor, Proteome, Sorting Nexins, Vesicular Transport Proteins, Viral Regulatory and Accessory Proteins, Viroporin Proteins, Hela Cells, Microbiology, Immunology, Medical Microbiology, Virology, Medical microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4m5527p7

المؤلفون: Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D, Teriete, Peter, Hull, Mitchell V, Chang, Max W, Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M, Cheng, Kuoyuan, Nguyen, Tu-Trinh H, Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P, Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M, Chapman, Mackenzie E, Lendy, Emma K, Glynne, Richard J, Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D, Johnson, Jeffrey R, Benner, Christopher, Sun, Ren, Schultz, Peter G, Su, Andrew I, García-Sastre, Adolfo, Chatterjee, Arnab K, Yuen, Kwok-Yung, Chanda, Sumit K

المصدر: Nature. 586(7827)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Emerging Infectious Diseases, Rare Diseases, Lung, Orphan Drug, Biodefense, Infectious Diseases, Vaccine Related, Pneumonia & Influenza, Pneumonia, Prevention, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Adenosine Monophosphate, Alanine, Alveolar Epithelial Cells, Antiviral Agents, Betacoronavirus, COVID-19, Cell Line, Coronavirus Infections, Cysteine Proteinase Inhibitors, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Drug Repositioning, Drug Synergism, Gene Expression Regulation, Humans, Hydrazones, Induced Pluripotent Stem Cells, Models, Biological, Morpholines, Pandemics, Pneumonia, Viral, Pyrimidines, Reproducibility of Results, SARS-CoV-2, Small Molecule Libraries, Triazines, Virus Internalization, Virus Replication, COVID-19 Drug Treatment, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6p88f41f

المؤلفون: Langer, Simon, Yin, Xin, Diaz, Arturo, Portillo, Alex J, Gordon, David E, Rogers, Umu H, Marlett, John M, Krogan, Nevan J, Young, John AT, Pache, Lars, Chanda, Sumit K

المصدر: Cells. 9(9)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Humans, HIV-1, HIV Infections, Cullin Proteins, NF-kappa B, Transfection, Virus Replication, Transcription, Genetic, Gene Expression Regulation, Viral, Binding Sites, Terminal Repeat Sequences, Blood Donors, NFATC Transcription Factors, Host-Pathogen Interactions, Gene Knockdown Techniques, HEK293 Cells, Cullin 3, NF-κB signaling, ubiquitin protein ligase, viral gene transcription, NF-kappa B signaling

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5347w59n

المؤلفون: Pache, Lars, Marsden, Matthew D, Teriete, Peter, Portillo, Alex J, Heimann, Dominik, Kim, Jocelyn T, Soliman, Mohamed SA, Dimapasoc, Melanie, Carmona, Camille, Celeridad, Maria, Spivak, Adam M, Planelles, Vicente, Cosford, Nicholas DP, Zack, Jerome A, Chanda, Sumit K

المصدر: Cell Reports Medicine. 1(3)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Human Fetal Tissue, HIV/AIDS, Biotechnology, Infectious Diseases, Infection, Animals, Anti-Retroviral Agents, Bone Marrow, Cells, Cultured, HIV Infections, HIV Seropositivity, HIV-1, Humans, Liver, Lymphocyte Activation, Mice, Mice, Inbred C57BL, NF-kappa B, Signal Transduction, Small Molecule Libraries, T-Lymphocytes, Thymus Gland, Virus Activation, Virus Latency, Virus Replication, BLT mouse model, HIV, HIV cure, LRA, Smac mimetics, humanized mouse model, latency, latency reversal agents, non-canonical NF-κB, shock and kill, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/27m5t3ts
https://escholarship.org/content/qt27m5t3ts/qt27m5t3ts.pdf