المؤلفون: Stock AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Manzoli V; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., De Toni T; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA., Abreu MM; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA., Poh YC; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ye L; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Roose A; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Pagliuca FW; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Thanos C; Semma Therapeutics, Inc., Cambridge, MA 02142, USA., Ricordi C; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Tomei AA; Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10(th) Avenue, Miami, FL 33136, USA; Department of Biomedical Engineering, University of Miami, Miami, FL 33146, USA; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: atomei@miami.edu.

المصدر: Stem cell reports [Stem Cell Reports] 2020 Jan 14; Vol. 14 (1), pp. 91-104. Date of Electronic Publication: 2019 Dec 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation* , Islets of Langerhans Transplantation*, Diabetes Mellitus, Type 1/*therapy , Insulin-Secreting Cells/*cytology , Stem Cells/*cytology, Animals ; Cells, Cultured ; Cryopreservation/methods ; Disease Models, Animal ; Female ; Humans ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Stem Cells/metabolism ; Transplantation, Heterologous

المؤلفون: Veres A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard Systems Biology PhD Program, Harvard University, Cambridge, MA, USA., Faust AL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Bushnell HL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Engquist EN; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Kenty JH; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Harb G; Semma Therapeutics, Cambridge, MA, USA., Poh YC; Semma Therapeutics, Cambridge, MA, USA., Sintov E; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Gürtler M; Semma Therapeutics, Cambridge, MA, USA., Pagliuca FW; Semma Therapeutics, Cambridge, MA, USA., Peterson QP; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. dmelton@harvard.edu.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. dmelton@harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. dmelton@harvard.edu.

المصدر: Nature [Nature] 2019 May; Vol. 569 (7756), pp. 368-373. Date of Electronic Publication: 2019 May 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*, Insulin-Secreting Cells/*cytology , Stem Cells/*cytology, Animals ; Biomarkers/metabolism ; Cell Lineage ; Cell Separation ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/classification ; Insulin-Secreting Cells/metabolism ; Integrin alpha1/metabolism ; Male ; Mice ; RNA-Seq ; Single-Cell Analysis ; Stem Cells/metabolism

المؤلفون: Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine in St. Louis, and Department of Biomedical Engineering, School of Engineering & Applied Science, Washington University in St. Louis, St. Louis, MO jmillman@wustl.edu., Pagliuca FW; Semma Therapeutics, Inc., Cambridge, MA f.pagliuca@semma-tx.com.

المصدر: Diabetes [Diabetes] 2017 May; Vol. 66 (5), pp. 1111-1120.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells*, Cell- and Tissue-Based Therapy/*methods , Diabetes Mellitus/*therapy , Insulin-Secreting Cells/*transplantation, Cell Differentiation ; Humans ; Patient Selection ; Transplantation, Autologous/methods

المؤلفون: Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA

المصدر: Nature communications [Nat Commun] 2016 Aug 04; Vol. 7, pp. 12379. Date of Electronic Publication: 2016 Aug 04.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.; Department of Biomedical Engineering, Washington University in St Louis, 1 Brookings Drive, St Louis, Missouri 63130, USA., Xie C; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA., Van Dervort A; Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA., Gürtler M; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA., Pagliuca FW; Semma Therapeutics, Inc. 450 Kendall Street, Suite 2B Cambridge, Massachusetts 02142, USA., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

المصدر: Nature communications [Nat Commun] 2016 May 10; Vol. 7, pp. 11463. Date of Electronic Publication: 2016 May 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 1/*pathology , Induced Pluripotent Stem Cells/*pathology , Insulin-Secreting Cells/*pathology, Animals ; Cell Differentiation ; Cells, Cultured ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/physiopathology ; Diabetes Mellitus, Experimental/therapy ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/physiopathology ; Humans ; Hypoglycemic Agents/pharmacology ; In Vitro Techniques ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/physiology ; Insulin ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/physiology ; Male ; Mice ; Mice, SCID ; Stem Cell Transplantation

المؤلفون: Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG

المصدر: Nature medicine [Nat Med] 2016 Apr; Vol. 22 (4), pp. 446.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: PubMed not MEDLINE

المؤلفون: Vegas AJ; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Veiseh O; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Gürtler M; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA., Millman JR; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA., Pagliuca FW; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA., Bader AR; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Doloff JC; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Li J; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Chen M; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Olejnik K; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Tam HH; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Jhunjhunwala S; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Langan E; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Aresta-Dasilva S; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., Gandham S; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA., McGarrigle JJ; Department of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA., Bochenek MA; Department of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA., Hollister-Lock J; Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA., Oberholzer J; Department of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, Illinois, USA., Greiner DL; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Weir GC; Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.; Howard Hughes Medical Institute (HHMI), Harvard University, Cambridge, Massachusetts, USA., Langer R; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Division of Health Science Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Anderson DG; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.; Department of Anesthesiology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Division of Health Science Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

المصدر: Nature medicine [Nat Med] 2016 Mar; Vol. 22 (3), pp. 306-11. Date of Electronic Publication: 2016 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Alginates* , Hydrogels*, Blood Glucose/*metabolism , C-Peptide/*metabolism , Cell Transplantation/*methods , Diabetes Mellitus, Experimental/*therapy , Diabetes Mellitus, Type 1/*therapy , Embryonic Stem Cells/*cytology , Foreign-Body Reaction/*prevention & control , Insulin-Secreting Cells/*transplantation, Animals ; Blotting, Western ; Cell Culture Techniques ; Cell Differentiation ; Chromatography, Liquid ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Immunocompetence ; Insulin/metabolism ; Insulin-Secreting Cells/cytology ; Insulin-Secreting Cells/metabolism ; Mice ; Microscopy, Confocal ; Microscopy, Phase-Contrast ; Morpholines ; Polymers ; Tandem Mass Spectrometry ; Triazoles

المؤلفون: Pagliuca FW; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Millman JR; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Gürtler M; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Segel M; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Van Dervort A; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Ryu JH; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Peterson QP; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA., Greiner D; Diabetes Center of Excellence, University of Massachusetts Medical School, 368 Plantation Street, AS7-2051, Worcester, MA 01605, USA., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: dmelton@harvard.edu.

المصدر: Cell [Cell] 2014 Oct 09; Vol. 159 (2), pp. 428-39.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Culture Techniques*, Insulin-Secreting Cells/*cytology, Animals ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Insulin/genetics ; Insulin/metabolism ; Islets of Langerhans ; Mice ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism

المؤلفون: Hrvatin S; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138., O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Feb 25; Vol. 111 (8), pp. 3038-43. Date of Electronic Publication: 2014 Feb 10.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*physiology , Insulin-Secreting Cells/*cytology , Pancreas/*cytology , Pluripotent Stem Cells/*cytology, Adult ; Cell Differentiation/genetics ; Fetus/cytology ; Fetus/metabolism ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Insulin-Secreting Cells/metabolism ; Microarray Analysis ; Pluripotent Stem Cells/metabolism

المؤلفون: Chetty S; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA., Pagliuca FW, Honore C, Kweudjeu A, Rezania A, Melton DA

المصدر: Nature methods [Nat Methods] 2013 Jun; Vol. 10 (6), pp. 553-6. Date of Electronic Publication: 2013 Apr 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*drug effects , Induced Pluripotent Stem Cells/*cytology, Cells, Cultured ; Dimethyl Sulfoxide/pharmacology ; Embryonic Stem Cells/cytology ; G1 Phase/drug effects ; Humans ; Retinoblastoma Protein/metabolism