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1
المؤلفون: Chengyi Zhang, Sujin Cho-Schultz, Tran Khanh Tuan, Manli Shi, Rose Ann Ferre, Sherry Niessen, Sajiv Krishnan Nair, Douglas Carl Behenna, Dac M. Dinh, Elaine E. Tseng, Theodore O. Johnson, Cheng Hengmiao, Ru Zhou, Michael Zientek, T. Eric Ballard, Brion W. Murray, Suvi T. M. Orr, James Solowiej, Jennifer Lafontaine, Jean Joo Matthews, Scott L. Weinrich, Paolo Vicini, Deal Judith G, Longqing Liu, John Charles Kath, Pairish Mason Alan, Simon Paul Planken, Louise Bernier, Deepak Dalvie, Yiqin Luo, Martin Paul Edwards, Asako Nagata, Hong Shen, Neal W. Sach, Yuli Wang, Ketan S. Gajiwala, Shuibo Xin, Simon Bailey, Chau Almaden, Robert Steven Kania, Michelle Hemkens
المصدر: Journal of Medicinal Chemistry. 60:3002-3019
مصطلحات موضوعية: 0301 basic medicine, Mutation, biology, Chemistry, Mutant, Wild type, medicine.disease_cause, Molecular biology, respiratory tract diseases, 03 medical and health sciences, T790M, 030104 developmental biology, Drug Discovery, biology.protein, medicine, Molecular Medicine, Kinome, Epidermal growth factor receptor, Erlotinib, ADME, medicine.drug
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2
المؤلفون: Marlena Walls, Tod Smeal, Suvi T. M. Orr, Zhengyu Liu, Cheng Hengmiao, Shuiwang Wang, Kephart Susan Elizabeth, Jean Joo Matthews, Rose Ann Ferre, Neal W. Sach, Scott L. Weinrich, Doug Behenna, Sherry Niessen, Sangita M. Baxi, Deepak Dalvie, Sujin Cho-Schultz, Dac M. Dinh, Kevin Ryan, Jim Solowiej, Elaine E. Tseng, Simon Paul Planken, Sajiv Krishnan Nair, Brion W. Murray, Jun Li Feng, Jennifer Lafontaine, Pairish Mason Alan, Shijian Ren, Michelle Hemkens, Shuibo Xin, Mehran Jalaie, Tran Khanh Tuan, Robert Steven Kania, Sutton Scott Channing, William F. Vernier, Kevin K.-C. Liu, Amy Jackson-Fisher, Beth Lunney, Min-Jean Yin, Ketan S. Gajiwala, Asako Nagata, Haiwei Xu, Michael Zientek, Ru Zhou, Daniel Tyler Richter, Simon Bailey, Martin Paul Edwards, Martha A. Ornelas, Chau Almaden, John Charles Kath, Hong Shen, Theodore O. Johnson
المصدر: Journal of Medicinal Chemistry. 59:2005-2024
مصطلحات موضوعية: 0301 basic medicine, Mutation, 010405 organic chemistry, Stereochemistry, Chemistry, Mutant, medicine.disease_cause, 01 natural sciences, respiratory tract diseases, 0104 chemical sciences, 03 medical and health sciences, T790M, 030104 developmental biology, Gefitinib, Protein kinase domain, Drug Discovery, Cancer research, medicine, Molecular Medicine, Potency, Reactivity (chemistry), Erlotinib, medicine.drug
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3
المؤلفون: Shaoxian Sun, Phuong Le, Shubha Bagrodia, Sadayappan V. Rahavendran, Eric Zhang, Cheng Hengmiao, Cathy Xiang, Robert Steven Kania, Jing Yuan, William Farrell, Jacqui Elizabeth Hoffman, Pairish Mason Alan, Deepak Dalvie
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2787-2792
مصطلحات موضوعية: Pyridones, Carboxylic acid, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pyrimidinones, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Amide, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Binding Sites, Kinase, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Xenograft Model Antitumor Assays, Protein Structure, Tertiary, Molecular Docking Simulation, Pyrimidines, Drug Design, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction
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4
المؤلفون: Kephart Susan Elizabeth, Annette John-Baptiste, Deal Judith G, Danlin Gu, Shubha Bagrodia, Cui Jingrong Jean, Shinji Yamazaki, Djamal Bouzida, Pairish Mason Alan, Evan Smith, Chuangxing Guo, Robert Steven Kania, Dong Liming, Angelica Linton, Indrawan James Mcalpine, Cynthia Louise Palmer
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7605-7609
مصطلحات موضوعية: Time Factors, Stereochemistry, Metabolite, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Electrons, Biochemistry, Dependent drug, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Biology, ADME, Ligand efficiency, Molecular Structure, Mutagenicity Tests, Kinase, Organic Chemistry, Drug interaction, chemistry, Reactive metabolite, Toxicity, Microsomes, Liver, Molecular Medicine, Oxidation-Reduction
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5
المؤلفون: Gilles H. Goetz, Michele McTigue, Max Parker, Ya-Li Deng, Nambu Mitchell David, J. Jean Cui, Shinji Yamazaki, Jia Lei, Neil Grodsky, Shirley A. Aguirre, Jacqui Elizabeth Hoffman, Kevin Ryan, Hong Shen, Phuong Le, Sergei Timofeevski, James G. Christensen, Helen Y. Zou, Cheng Hengmiao, Brion W. Murray, Michelle Tran-Dubé, Mehran Jalaie, Qiuhua Li, Pairish Mason Alan
المصدر: Journal of Medicinal Chemistry. 55:8091-8109
مصطلحات موضوعية: biology, Hydrazide, medicine.disease_cause, Receptor tyrosine kinase, chemistry.chemical_compound, chemistry, Biochemistry, Tumor progression, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Mesenchymal–epithelial transition, Transferase, Oxindole, Protein kinase A, Carcinogenesis
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6
المؤلفون: Jon Engebretsen, Martha A. Ornelas, Kephart Susan Elizabeth, Natilie Hosea, Angelica Linton, Asako Nagata, Javier Gonzalez, Samantha Elizabeth Greasley, Chuangxing Guo, Andrea Fanjul, Pairish Mason Alan, Jeff Elleraas
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1230-1236
مصطلحات موضوعية: Male, Models, Molecular, Lactams, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, Prostate cancer, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, ADME, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Chemistry, Organic Chemistry, Antagonist, Prostatic Neoplasms, Stereoisomerism, medicine.disease, High-Throughput Screening Assays, Androgen receptor, Receptors, Androgen, Lactam, Molecular Medicine
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7
المؤلفون: Qiyue Hu, Kephart Susan Elizabeth, Angelica Linton, Pairish Mason Alan, Ying Jiang, Chuangxing Guo, Ping Kang, Martha A. Ornelas
المصدر: Journal of Medicinal Chemistry. 54:7705-7712
مصطلحات موضوعية: Models, Molecular, Pyrimidine, Stereochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Protein structure, In vivo, Catalytic Domain, Drug Discovery, Humans, Moiety, Aldehyde oxidase, Drug discovery, Imidazoles, Stereoisomerism, Metabolism, Bridged Bicyclo Compounds, Heterocyclic, Aldehyde Oxidase, Androgen receptor, Pyrimidines, Biochemistry, chemistry, Molecular Medicine, Oxidation-Reduction, Cyclobutanes, Protein Binding
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8
المؤلفون: Kephart Susan Elizabeth, Angelica Linton, Javier Gonzalez, Kevin D. Bunker, Paul F. Richardson, Chuangxing Guo, Pairish Mason Alan, Martha A. Ornelas, Neal W. Sach
المصدر: Tetrahedron Letters. 52:4760-4763
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, polycyclic compounds, Lactam, Organic chemistry, biochemical phenomena, metabolism, and nutrition, Biochemistry, Reductive amination
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9
المؤلفون: Mehran Jalaie, Angelica Linton, Xin Wu, Pairish Mason Alan, Martha A. Ornelas, Kephart Susan Elizabeth, Chuangxing Guo, Michael J. Hickey, Xiaodong Ji, John Li, Karen A. Maegley, Samantha Elizabeth Greasley, Paul G. Richardson, Zhi Xie
المصدر: Bioorganicmedicinal chemistry letters. 23(11)
مصطلحات موضوعية: Gene isoform, Thyroid Hormones, Stereochemistry, High-throughput screening, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pyrimidinones, PKM2, Biochemistry, Cell Line, Structure-Activity Relationship, Drug Discovery, Humans, Molecular Biology, Binding Sites, Chemistry, Activator (genetics), Organic Chemistry, Membrane Proteins, Metabolism, Warburg effect, High-Throughput Screening Assays, Protein Structure, Tertiary, Molecular Docking Simulation, Kinetics, Cancer cell, Molecular Medicine, Computer-Aided Design, Benzimidazoles, Carrier Proteins, Pyruvate kinase, Protein Binding
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10
المؤلفون: Martha A. Ornelas, Benjamin J. Burke, Angelica Linton, Kephart Susan Elizabeth, Andrea Fanjul, Jon Engebretsen, Asako Nagata, Pairish Mason Alan, Chuangxing Guo, Dong Liming
المصدر: Bioorganicmedicinal chemistry letters. 22(7)
مصطلحات موضوعية: Male, Models, Molecular, Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Ligands, Biochemistry, Protein Structure, Secondary, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Androgen Receptor Antagonists, Humans, Oxindole, Solubility, Molecular Biology, Ligand efficiency, Improved solubility, Chemistry, Organic Chemistry, Antagonist, Prostatic Neoplasms, Ligand binding domain, Protein Structure, Tertiary, Androgen receptor, Receptors, Androgen, Drug Design, Molecular Medicine, Benzimidazoles, Protein Binding