المؤلفون: Aydin G; Traditional and Complementary Medicine Application and Research Center, School of Medicine, Duzce University, Duzce, Turkey.; Department of Chemistry, Faculty of Arts and Sciences, Istanbul Technical University, Istanbul, Turkey.; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey., Paksoy MN; Department of Medical Biology, School of Medicine, Bahcesehir University, Istanbul, Turkey., Orhan MD; Department of Medical Biology, School of Medicine, Bahcesehir University, Istanbul, Turkey., Avsar T; Department of Medical Biology, School of Medicine, Bahcesehir University, Istanbul, Turkey., Yurtsever M; Department of Chemistry, Faculty of Arts and Sciences, Istanbul Technical University, Istanbul, Turkey., Durdagi S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey.

المصدر: Chemical biology & drug design [Chem Biol Drug Des] 2020 Jul; Vol. 96 (1), pp. 684-700.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Enzyme Inhibitors/*chemistry , Proto-Oncogene Proteins c-mdm2/*metabolism , Small Molecule Libraries/*chemistry , Tumor Suppressor Protein p53/*metabolism, Animals ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacokinetics ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/pharmacokinetics ; High-Throughput Screening Assays/methods ; Humans ; Mice ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors ; Quantitative Structure-Activity Relationship ; Small Molecule Libraries/pharmacokinetics