المؤلفون: Chen JB; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan.; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom., Ramadani F; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Pang MOY; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Beavil RL; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma Protein Production Facility, London, United Kingdom., Holdom MD; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Mitropoulou AN; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Beavil AJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Gould HJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Chang TW; Genomics Research Center, Academia Sinica, Taipei, 115, Taiwan., Sutton BJ; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. brian.sutton@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. brian.sutton@kcl.ac.uk., McDonnell JM; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. james.mcdonnell@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. james.mcdonnell@kcl.ac.uk., Davies AM; King's College London, Randall Centre for Cell and Molecular Biophysics, London, SE1 1UL, United Kingdom. anna.davies@kcl.ac.uk.; Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. anna.davies@kcl.ac.uk.

المصدر: Scientific reports [Sci Rep] 2018 Aug 01; Vol. 8 (1), pp. 11548. Date of Electronic Publication: 2018 Aug 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Anti-Idiotypic/*chemistry , Antibodies, Anti-Idiotypic/*metabolism , Immunoglobulin E/*chemistry , Immunoglobulin E/*metabolism , Receptors, IgE/*metabolism, B-Lymphocytes/immunology ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/metabolism ; Mast Cells/immunology ; Protein Binding ; Protein Conformation

المؤلفون: Davies AM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Allan EG; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Keeble AH; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Delgado J; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Cossins BP; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Mitropoulou AN; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Pang MOY; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Ceska T; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Beavil AJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Craggs G; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Westwood M; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Henry AJ; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., McDonnell JM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, james.mcdonnell@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Sutton BJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, brian.sutton@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.

المصدر: The Journal of biological chemistry [J Biol Chem] 2017 Jun 16; Vol. 292 (24), pp. 9975-9987. Date of Electronic Publication: 2017 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Anti-Asthmatic Agents/*pharmacology , Immunoglobulin E/*metabolism , Omalizumab/*pharmacology , Receptors, IgE/*antagonists & inhibitors, Allosteric Site ; Amino Acid Substitution ; Crystallography, X-Ray ; Fluorescence Resonance Energy Transfer ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin E/genetics ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fab Fragments/pharmacology ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/metabolism ; Immunoglobulin Fc Fragments/pharmacology ; Omalizumab/chemistry ; Omalizumab/genetics ; Omalizumab/metabolism ; Pliability ; Point Mutation ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Refolding ; Receptors, IgE/chemistry ; Receptors, IgE/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Solubility ; Surface Plasmon Resonance