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المؤلفون: Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer, Andreas Weiss, Rainer Wilcken, Daniel A. Guthy, Andreas Lingel, Claudio Bomio-Confaglia, Rainer Machauer, Pascal Rigollier, Johannes Ottl, Dorothee Arz, Pascal Bernet, Gaëlle Desjonqueres, Solene Dussauge, Malika Kazic-Legueux, Marie-Anne Lozac’h, Christophe Mura, Mickaël Sorge, Milen Todorov, Nicolas Warin, Florence Zink, Hans Voshol, Frederic J. Zecri, Richard C. Sedrani, Nils Ostermann, Saskia M. Brachmann, Simona Cotesta
المصدر: Journal of Medicinal Chemistry. 65:16173-16203
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d58af020ff3289026b12e3df1b9a0f4
https://doi.org/10.1158/2159-8290.22541471.v1 -
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المؤلفون: Saskia M. Brachmann, Simona Cotesta, Anna F. Farago, Frederic Zecri, Kun Xu, Rainer Wilcken, Toni Widmer, Peter Wessels, Hans Voshol, Andrea Vaupel, Rowan Stringer, Toshio Shimizu, Richard Sedrani, Christian Schnell, Danielle Roman, Pascal Rigollier, Johannes Ottl, Nils Ostermann, Helen Oakman, Jason Murphy, Sauveur-Michel Maira, Catherine Leblanc, Jeffrey D. Kearns, Eloísa Jiménez Núñez, Ashley Jaeger, Victoria Head, Daniel Alexander Guthy, Marc Gerspacher, Carmine Fedele, Lekshmi Dharmarajan, Ruben de Kanter, Xiaoming Cui, Xueying Chen, Heather Burks, Claudio Bomio-Confaglia, Kim S. Beyer, Louise Barys, Edwige Lorthiois, Andreas Weiss
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090908cffff39039ae33828ed26022f4
https://doi.org/10.1158/2159-8290.c.6549647 -
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المؤلفون: Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S. Beyer, Claudio Bomio-Confaglia, Heather Burks, Xueying Chen, Xiaoming Cui, Ruben de Kanter, Lekshmi Dharmarajan, Carmine Fedele, Marc Gerspacher, Daniel Alexander Guthy, Victoria Head, Ashley Jaeger, Eloísa Jiménez Núñez, Jeffrey D. Kearns, Catherine Leblanc, Sauveur-Michel Maira, Jason Murphy, Helen Oakman, Nils Ostermann, Johannes Ottl, Pascal Rigollier, Danielle Roman, Christian Schnell, Richard Sedrani, Toshio Shimizu, Rowan Stringer, Andrea Vaupel, Hans Voshol, Peter Wessels, Toni Widmer, Rainer Wilcken, Kun Xu, Frederic Zecri, Anna F. Farago, Simona Cotesta, Saskia M. Brachmann
المصدر: Cancer Discovery. 12:1500-1517
مصطلحات موضوعية: Proto-Oncogene Proteins p21(ras), Indazoles, Oncology, Neoplasms, Mutation, Humans, Enzyme Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edd83624df412b8b1d836bfe665fa6
https://doi.org/10.1158/2159-8290.cd-22-0158 -
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المؤلفون: Edwige, Lorthiois, Marc, Gerspacher, Kim S, Beyer, Andrea, Vaupel, Catherine, Leblanc, Rowan, Stringer, Andreas, Weiss, Rainer, Wilcken, Daniel A, Guthy, Andreas, Lingel, Claudio, Bomio-Confaglia, Rainer, Machauer, Pascal, Rigollier, Johannes, Ottl, Dorothee, Arz, Pascal, Bernet, Gaëlle, Desjonqueres, Solene, Dussauge, Malika, Kazic-Legueux, Marie-Anne, Lozac'h, Christophe, Mura, Mickaël, Sorge, Milen, Todorov, Nicolas, Warin, Florence, Zink, Hans, Voshol, Frederic J, Zecri, Richard C, Sedrani, Nils, Ostermann, Saskia M, Brachmann, Simona, Cotesta
المصدر: Journal of medicinal chemistry.
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المؤلفون: Casey J. N. Mathison, Mihai Azimioara, Christopher Cow, Pascal Rigollier, Ursula Bodendorf, Pierre-Yves Michellys, Victor Nikulin, Daniel Pflieger, Ben Wen, Bo Liu, Samantha Zaharevitz, Trixi Brandl, Danilo Guerini, Daniel R. Beisner, Juraj Velcicky, Robert Epple
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Myeloid, CD74, 010405 organic chemistry, Chemistry, Organic Chemistry, Substrate (chemistry), 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Transformation (genetics), Immune system, medicine.anatomical_structure, Orally active, In vivo, Drug Discovery, medicine, Function (biology)
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المؤلفون: Roland Feifel, Philip C. Smith, Ursula Bodendorf, Robert Epple, Philippe Couttet, Reiner Aichholz, Danilo Guerini, Ina Dix, Ben Wen, Bo Liu, Peter Wipfli, Juraj Velcicky, Toni Widmer, Trixi Brandl, Daniel R. Beisner, Pascal Rigollier
المصدر: Journal of Medicinal Chemistry. 61:865-880
مصطلحات موضوعية: 0301 basic medicine, Signal peptide, Myeloid, Intramembrane protease, Mutant, Administration, Oral, Biological Availability, Pharmacology, Inhibitory Concentration 50, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Immunologic Factors, Antigen-presenting cell, chemistry.chemical_classification, biology, HEK 293 cells, Rats, HEK293 Cells, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, biology.protein, Pyrazoles, Molecular Medicine
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المؤلفون: Heinz Ruffner, Fred Harbinski, Arun Ramamurthy, Jeremy L. Jenkins, Tewis Bouwmeester, Lac Lee, Paola Grandi, Jennifer A. DaSilva, Barbara Wilmeringwetter, Rishi K. Jain, Showalter Todd, Luis Llamas, Frederic Bassilana, Aaron Bourret, Adam Carlson, Jeffrey A. Porter, Xu Wu, Solange Vidal, Peter M. Finan, Pascal Rigollier, Markus Schirle, Joseph Kelleher, Bianka L. Grosshans, Klaus Seuwen, Samantha Plonsky, John A. Tallarico, Valerie Beck, Andreas W. Sailer, Sarah J. Luchansky, Vic E. Myer
المصدر: Nature Chemical Biology. 10:343-349
مصطلحات موضوعية: Proteomics, Orphan receptor, Chemistry, Cell Biology, Ci protein, Chromatography, Affinity, Hedgehog signaling pathway, Receptors, G-Protein-Coupled, Cell biology, Tandem Mass Spectrometry, Hedgehog Proteins, Signal transduction, Smoothened, Molecular Biology, Transcription factor, Hedgehog, Signal Transduction, G protein-coupled receptor
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المؤلفون: Simon Ruedisser, Nikolaus Schiering, P. Erbel, Pascal Rigollier, Andreas Boettcher, D. Vinzenz, Julian Woelcke, Ulrich Hassiepen, Lorenz M. Mayr
المصدر: SLAS Discovery. 15:1029-1041
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Light, medicine.medical_treatment, Drug Evaluation, Preclinical, Biochemistry, Fluorescence, Mass Spectrometry, Analytical Chemistry, Matrix Metalloproteinase 12, medicine, Animals, Humans, Scattering, Radiation, False Positive Reactions, Trypsin, Electrophoretic mobility shift assay, Surface plasmon resonance, False Negative Reactions, Serine protease, Protease, biology, Chemistry, Drug discovery, Nuclear magnetic resonance spectroscopy, Surface Plasmon Resonance, Peptide Fragments, Enzyme assay, Kinetics, Solubility, biology.protein, Feasibility Studies, Molecular Medicine, Biological Assay, Cattle, Chromatography, Liquid, Biotechnology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93a4c872a350ce148e8a1b550689f91
https://doi.org/10.1177/1087057110380455 -
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المؤلفون: Lan-Ying Qin, Kurt W. Saionz, Roland E. Dolle, Baldwin John J, Marc-Raleigh Brescia, Joan J. Zhang, James R. Wareing, Ian R. Henderson, Juerg Zimmermann, Axel Metzger, Pascal Rigollier, Hubert Gstach, Andrew G. Cole
المصدر: Tetrahedron Letters. 51:4486-4489
مصطلحات موضوعية: Organic Chemistry, Biochemistry, Combinatorial chemistry, Chloride, Acylation, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, medicine, Amine gas treating, Derivative (chemistry), Cysteine, medicine.drug