نتائج البحث - "Pasi Halonen"

المصدر: Cell Reports, Vol 7, Iss 1, Pp 86-93 (2014)
Cell Reports, 7(1), 86-93. Cell Press
Sun, C, Hobor, S, Bertotti, A, Zecchin, D, Huang, S D, Galimi, F, Cottino, F, Prahallad, A, Grernrum, W, Tzani, A, Schlicker, A, Wessels, L F A, Smit, E F, Thunnissen, E, Halonen, P, Lieftink, C, Beijersbergen, R L, Di Nicolantonio, F, Bardelli, A, Trusolino, L & Bernards, R 2014, ' Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 ', Cell Reports, vol. 7, no. 1, pp. 86-93 . https://doi.org/10.1016/j.celrep.2014.02.045

مصطلحات موضوعية: Lung Neoplasms, Receptor, ErbB-3, Receptor, ErbB-2, MYC PROTEIN STABILITY, DRUG-SENSITIVITY, RAS ONCOGENES, C-MYC, KINASE, PHOSPHORYLATION, MELANOMA, RECEPTOR, BRAF, Mutant, Apoptosis, Synthetic lethality, medicine.disease_cause, Receptor tyrosine kinase, Mice, 0302 clinical medicine, ERBB3, RNA, Small Interfering, lcsh:QH301-705.5, 0303 health sciences, biology, Kinase, Melanoma, Drug Synergism, MAP Kinase Kinase Kinases, 3. Good health, ErbB Receptors, 030220 oncology & carcinogenesis, Colonic Neoplasms, KRAS, Mice, Nude, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Animals, Humans, Protein Kinase Inhibitors, 030304 developmental biology, medicine.disease, Xenograft Model Antitumor Assays, lcsh:Biology (General), Mutation, ras Proteins, biology.protein, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8174e1a0a10a1475124eecd8ad1936c9
http://www.sciencedirect.com/science/article/pii/S2211124714001612

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9

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma

المؤلفون: René Bernards, Rodrigo Leite de Oliveira, Cor Lieftink, Roderick L. Beijersbergen, Tonći Šuštić, Pasi Halonen, Michel M. van den Heuvel, Marieke van de Ven, Michiel S. van der Heijden, Liqin Wang

المصدر: European Urology, 71, 6, pp. 858-862
European Urology, 71, 858-862

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Aminopyridines, Synthetic lethality, Receptor tyrosine kinase, Piperazines, 0302 clinical medicine, Erdafitinib, Antineoplastic Combined Chemotherapy Protocols, Medicine, Epidermal growth factor receptor, Molecular Targeted Therapy, Genetics, biology, Drug Synergism, Tumor Burden, Fibroblast growth factor receptor, 030220 oncology & carcinogenesis, embryonic structures, Benzamides, RNA Interference, biological phenomena, cell phenomena, and immunity, Signal Transduction, musculoskeletal diseases, animal structures, Class I Phosphatidylinositol 3-Kinases, Urology, FGFR Inhibition, Morpholines, Mice, Nude, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Transfection, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Protein Kinase Inhibitors, Phosphoinositide 3-kinase, Dose-Response Relationship, Drug, business.industry, Carcinoma, FGFR Inhibitor AZD4547, Receptors, Fibroblast Growth Factor, Xenograft Model Antitumor Assays, 030104 developmental biology, Urinary Bladder Neoplasms, Drug Resistance, Neoplasm, Mutation, biology.protein, Cancer research, Pyrazoles, Urothelium, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536320546e1be20617564a45732bf2ef
https://pubmed.ncbi.nlm.nih.gov/28214032

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Full Text via ClinicalKey

10

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

المؤلفون: Sedef Iskit, Daniel S. Peeper, Aida Shahrabi, Pasi Halonen, Patricia A. Possik, Cor Lieftink, Roderick L. Beijersbergen

المساهمون: Pathology, CCA - Target Discovery & Preclinial Therapy Development

المصدر: Oncotarget, 7(28), 42859-42872. Impact Journals
Iskit, S, Lieftink, C, Halonen, P, Shahrabi, A, Possik, P A, Beijersbergen, R L & Peeper, D S 2016, ' Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer ', Oncotarget, vol. 7, no. 28, pp. 42859-42872 . https://doi.org/10.18632/oncotarget.10230
Oncotarget

مصطلحات موضوعية: 0301 basic medicine, in vivo screen, medicine.medical_treatment, EGFR, Triple Negative Breast Neoplasms, Disease, Mice, SCID, Pharmacology, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, In vivo, Mice, Inbred NOD, Cell Line, Tumor, ROCK, medicine, Animals, Humans, Protein Kinase Inhibitors, Triple-negative breast cancer, Cell Proliferation, Mice, Knockout, rho-Associated Kinases, business.industry, Cell growth, Drug Synergism, medicine.disease, targeted therapy, Xenograft Model Antitumor Assays, ErbB Receptors, 030104 developmental biology, HEK293 Cells, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, RNA Interference, business, TNBC, Genetic screen, Priority Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b2e2a76375475dfd26f61f987f1eb1
https://research.vumc.nl/en/publications/a7697ee0-2515-4fac-a7a9-94858798e39b

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