المؤلفون: Gangnale LD; Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Miriyala SRT; Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Pasunooti KK; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Reddy DS; Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.; Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

المصدر: The Journal of organic chemistry [J Org Chem] 2023 Dec 15; Vol. 88 (24), pp. 17330-17344. Date of Electronic Publication: 2023 Dec 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Voggu R; Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly Known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad 500076, Telangana, India.; Department of Engineering Chemistry, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India., Karmakar A; Molecular Science Laboratory, National Institute of Immunology, New Delhi 110067, India., Puli VS; Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly Known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad 500076, Telangana, India., Damerla VSB; Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly Known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad 500076, Telangana, India., Mogili P; Department of Engineering Chemistry, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India., Amaladass P; Department of Chemistry, Madanapalle Institute of Technology & Science, Madanapalle 517325, Andhra Pradesh, India., Chidara S; Department of Medicinal Chemistry, Aragen Life Sciences Pvt. Ltd. (Formerly Known as GVK Biosciences Pvt. Ltd.), IDA, Nacharam, Hyderabad 500076, Telangana, India., Pasunooti KK; ProSAM Bioscience Pvt. Ltd., Hyderabad 500049, Telangana, India.; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Gupta S; Molecular Science Laboratory, National Institute of Immunology, New Delhi 110067, India.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jun 24; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/chemistry, Female ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Molecular Docking Simulation ; Etoposide/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Drug Design

المؤلفون: Liu F; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China.; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China., Cheng X; Department of Anaesthesiology, Weifang People's Hospital (The First Affiliated Hospital of Weifang Medical University), Weifang, China., Wang Y; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China.; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China., Li K; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China., Peng T; Department of Anaesthesiology, Weifang People's Hospital (The First Affiliated Hospital of Weifang Medical University), Weifang, China., Fang N; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China., Pasunooti KK; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States., Jun S; Division of Cardiology, Johns Hopkins University Medical Institutions, Baltimore, MD, United States., Yang X; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China.; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.; Department of Cardiology, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Wu J; Department of Anaesthesiology, Qilu Hospital of Shandong University, Jinan, China.; Department of Anaesthesiology and Perioperative Medicine, Qilu Hospital Dezhou Hospital, Shandong University, Dezhou, China.

المصدر: Frontiers in pharmacology [Front Pharmacol] 2023 Apr 18; Vol. 14, pp. 1131391. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Li Y; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Pasunooti KK; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Peng H; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Li RJ; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Shi WQ; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Liu W; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Cheng Z; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Head SA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States., Liu JO; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Apr 08; Vol. 11 (6), pp. 1111-1117. Date of Electronic Publication: 2020 Apr 08 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Zhong W; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore.; NTU Institute of Structural Biology , Nanyang Technological University , 636921 Singapore., Pasunooti KK; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Balamkundu S; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Wong YH; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore.; NTU Institute of Structural Biology , Nanyang Technological University , 636921 Singapore., Nah Q; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Gadi V; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Gnanakalai S; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Chionh YH; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., McBee ME; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore., Gopal P; Yong Loo Lin School of Medicine , National University of Singapore , 117597 Singapore., Lim SH; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore., Olivier N, Buurman ET, Dick T; Yong Loo Lin School of Medicine , National University of Singapore , 117597 Singapore., Liu CF; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore., Lescar J; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore.; NTU Institute of Structural Biology , Nanyang Technological University , 636921 Singapore., Dedon PC; Infectious Disease and Antimicrobial Resistance Interdisciplinary Research Groups , Singapore-MIT Alliance for Research and Technology , 1 CREATE Way , 138602 Singapore.; Department of Biological Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Sep 12; Vol. 62 (17), pp. 7788-7805. Date of Electronic Publication: 2019 Aug 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Pyrimidines/*pharmacology , Tyrosine/*pharmacology , tRNA Methyltransferases/*antagonists & inhibitors, Binding Sites/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Structure ; Pseudomonas aeruginosa/enzymology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tyrosine/chemistry ; tRNA Methyltransferases/metabolism

المؤلفون: Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11158-11168. Date of Electronic Publication: 2018 Dec 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*chemistry , Angiogenesis Inhibitors/*pharmacology , Cytochrome P-450 CYP3A Inhibitors/*pharmacology , Itraconazole/*analogs & derivatives, Cell Proliferation/drug effects ; Cytochrome P-450 CYP3A Inhibitors/chemistry ; Drug Evaluation, Preclinical/methods ; Human Umbilical Vein Endothelial Cells ; Humans ; Structure-Activity Relationship ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Tetrazoles/chemistry

المؤلفون: Bauer L; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands., Ferla S; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK., Head SA; Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Bhat S; Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Pasunooti KK; Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Shi WQ; Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Albulescu L; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands., Liu JO; Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Brancale A; Medicinal Chemistry, School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK., van Kuppeveld FJM; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands., Strating JRPM; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands. Electronic address: j.strating@uu.nl.

المصدر: Antiviral research [Antiviral Res] 2018 Aug; Vol. 156, pp. 55-63. Date of Electronic Publication: 2018 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res

مواضيع طبية MeSH: Structure-Activity Relationship*, Antiviral Agents/*pharmacology , Itraconazole/*pharmacology , Picornaviridae/*drug effects , Receptors, Steroid/*metabolism , Virus Replication/*drug effects, Antiviral Agents/chemistry ; HeLa Cells ; Humans ; Itraconazole/chemistry ; Molecular Dynamics Simulation ; Picornaviridae/physiology ; Protein Binding

المؤلفون: Bi X; School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, 637551, Singapore., Pasunooti KK; School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, 637551, Singapore., Lescar J; School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, 637551, Singapore., Liu CF; School of Biological Sciences, Nanyang Technological University , 60 Nanyang Drive, 637551, Singapore.

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2017 Feb 15; Vol. 28 (2), pp. 325-329. Date of Electronic Publication: 2016 Dec 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aldehydes/*chemistry , Peptides/*chemistry , Proteins/*chemistry , Thiazolidines/*chemistry, Amino Acid Sequence ; Binding Sites ; Models, Molecular ; Oxidation-Reduction ; Protein Structure, Secondary

المؤلفون: Head SA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States., Shi WQ; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; Department of Chemistry and Biochemistry, University of Arkansas , Fayetteville, Arkansas 72701, United States., Yang EJ; Faculty of Health Sciences, University of Macau , Taipa, Macau SAR China., Nacev BA; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States., Hong SY; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States., Pasunooti KK; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; Division of Structural Biology & Biochemistry, School of Biological Sciences, Nanyang Technological University , Singapore., Li RJ; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States., Shim JS; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; Faculty of Health Sciences, University of Macau , Taipa, Macau SAR China., Liu JO; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; SJ Yan and HJ Mao Laboratory of Chemical Biology, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.; Department of Oncology, Johns Hopkins School of Medicine , Baltimore, Maryland 21205, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Jan 20; Vol. 12 (1), pp. 174-182. Date of Electronic Publication: 2016 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*pharmacology , Antifungal Agents/*pharmacology , Carrier Proteins/*metabolism , Itraconazole/*pharmacology , Membrane Glycoproteins/*metabolism , Signal Transduction/*drug effects , TOR Serine-Threonine Kinases/*metabolism , Voltage-Dependent Anion Channel 1/*metabolism, AMP-Activated Protein Kinases/metabolism ; Biological Transport/drug effects ; Cell Proliferation/drug effects ; Cholesterol/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Molecular Docking Simulation ; Niemann-Pick C1 Protein ; TOR Serine-Threonine Kinases/antagonists & inhibitors

المؤلفون: Bi X; Division of Structural Biology and Biochemistry, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. cfliu@ntu.edu.sg., Pasunooti KK, Tareq AH, Takyi-Williams J, Liu CF

المصدر: Organic & biomolecular chemistry [Org Biomol Chem] 2016 Jun 21; Vol. 14 (23), pp. 5282-5. Date of Electronic Publication: 2016 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Codon/*genetics , Proteins/*chemistry , Proteins/*metabolism , Sulfhydryl Compounds/*chemistry , Thiazolidines/*metabolism, Aldehydes/chemistry ; Biotinylation ; Models, Molecular ; Protein Structure, Secondary ; Proteins/genetics ; Substrate Specificity ; Ubiquitination