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1دورية أكاديمية
المؤلفون: Jordi Gracia‐Sancho, Nicolò Manicardi, Martí Ortega‐Ribera, Raquel Maeso‐Díaz, Sergi Guixé‐Muntet, Anabel Fernández‐Iglesias, Diana Hide, Héctor García‐Calderó, Zoe Boyer‐Díaz, Patricia C. Contreras, Alfred Spada, Jaime Bosch
المصدر: Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)
مصطلحات موضوعية: Diseases of the digestive system. Gastroenterology, RC799-869
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2471-254X
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المؤلفون: Diana Hide, Jordi Gracia-Sancho, Zoe Boyer-Diaz, Anabel Fernández-Iglesias, Alfred P. Spada, Raquel Maeso-Díaz, Sergi Guixé-Muntet, Nicolò Manicardi, Patricia C. Contreras, Héctor García-Calderó, Martí Ortega-Ribera, Jaime Bosch
المصدر: Hepatology Communications
Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)
Gracia-Sancho, Jordi; Manicardi, Nicolò; Ortega-Ribera, Martí; Maeso-Díaz, Raquel; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Hide, Diana; García-Calderó, Héctor; Boyer-Díaz, Zoe; Contreras, Patricia C; Spada, Alfred; Bosch, Jaime (2019). Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism. Hepatology communications, 3(7), pp. 987-1000. 10.1002/hep4.1360 <http://dx.doi.org/10.1002/hep4.1360>مصطلحات موضوعية: Pathology, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Portal venous pressure, 610 Medicine & health, Original Articles, medicine.disease, Chronic liver disease, medicine.anatomical_structure, Fibrosis, Hepatocyte, medicine, Hepatic stellate cell, Portal hypertension, lcsh:Diseases of the digestive system. Gastroenterology, Original Article, Liver function, lcsh:RC799-869, business
وصف الملف: application/pdf
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المصدر: Toxicological Sciences. 162:396-405
مصطلحات موضوعية: Male, 0301 basic medicine, Primary Cell Culture, Caspase Inhibition and Hepatic Tissue Factor-Mediated Coagulation, Apoptosis, Caspase 3, 030204 cardiovascular system & hematology, Toxicology, Thromboplastin, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, medicine, Animals, fas Receptor, Blood Coagulation, Caspase, Liver injury, biology, Chemistry, Microvesicle, medicine.disease, Caspase Inhibitors, Molecular biology, Microvesicles, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Liver, Hepatocyte, Microvessels, Hepatocytes, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7628c69efaf4f462e63d4061351c3ce0
https://doi.org/10.1093/toxsci/kfx268 -
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المؤلفون: Gregory J. Gores, Vikas K. Verma, Patrick S. Kamath, Harmeet Malhi, Ruisi Wang, Sheng Cao, Yaming Liu, Vijay H. Shah, Malek Mushref, Patricia C. Contreras, Haiyang Li, Petra Hirsova
المصدر: Journal of Hepatology. 64:651-660
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, CD40 Ligand, Apoptosis, Inflammation, Article, Proinflammatory cytokine, Extracellular Vesicles, Mice, 03 medical and health sciences, medicine, Animals, Humans, Macrophage, Liver Diseases, Alcoholic, Caspase, Alcohol dehydrogenase, CD40, Ethanol, Hepatology, biology, Cytochrome P-450 CYP2E1, Hep G2 Cells, Macrophage Activation, Molecular biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Biochemistry, Caspases, Hepatocyte, Hepatocytes, biology.protein, Female, medicine.symptom
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المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Niel C. Hoglen, Patricia C. Contreras, Brad P. Hirakawa, Long-Shiuh Chen, Todd Groessl, Craig D. Fisher
المصدر: Journal of Pharmacology and Experimental Therapeutics. 309:634-640
مصطلحات موضوعية: Male, Pharmacology, Rats, Sprague-Dawley, Mice, Liver disease, Pharmacokinetics, In vivo, Oral administration, medicine, Animals, Potency, Enzyme Inhibitors, Pentanoic Acids, Caspase, Liver injury, Mice, Inbred BALB C, biology, business.industry, medicine.disease, Caspase Inhibitors, Rats, Apoptosis, Models, Animal, biology.protein, Molecular Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cd6072fda815132c80b024022dc888
https://doi.org/10.1124/jpet.103.062034 -
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المؤلفون: Patricia C. Contreras, Elizabeth J. Koury, Ratan V. Bhat, Thomas M. Engber, Matthew S. Miller, James P. Finn, Craig A. Dionne, Walton Kevin M
المصدر: Journal of Neurochemistry. 70:558-571
مصطلحات موضوعية: MAPK/ERK pathway, Cytoplasm, endocrine system, MAP Kinase Kinase 1, Protein Serine-Threonine Kinases, Biology, Hippocampus, environment and public health, Biochemistry, c-Fos, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, ELK1, Animals, Enzyme Inhibitors, Phosphorylation, Nuclear protein, Cell Nucleus, Cerebral Cortex, Flavonoids, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase Kinases, Electroshock, Mitogen-Activated Protein Kinase 3, Kinase, Brain, Protein-Tyrosine Kinases, Rats, Cell biology, enzymes and coenzymes (carbohydrates), Organ Specificity, Calcium-Calmodulin-Dependent Protein Kinases, biology.protein, Mitogen-Activated Protein Kinases, biological phenomena, cell phenomena, and immunity, Signal transduction, Microtubule-Associated Proteins, Proto-Oncogene Proteins c-fos, hormones, hormone substitutes, and hormone antagonists, Signal Transduction
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المؤلفون: Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
المصدر: Drug Development Research. 52:579-586
مصطلحات موضوعية: biology, business.industry, Central nervous system, Ischemia, Caspase 3, Pharmacology, medicine.disease, Neuroprotection, medicine.anatomical_structure, Apoptosis, Anesthesia, medicine.artery, Drug Discovery, Middle cerebral artery, medicine, biology.protein, Artery occlusion, business, Caspase
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المؤلفون: Dorothy G. Flood, James P. Finn, Ratan V. Bhat, Craig A. Dionne, Walton Kevin M, Matthew S. Miller, Patricia C. Contreras
المصدر: The Journal of Comparative Neurology. 398:373-392
مصطلحات موضوعية: MAPK/ERK pathway, Kinase, General Neuroscience, p38 mitogen-activated protein kinases, Mitogen-activated protein kinase, biology.protein, ASK1, Biology, Protein kinase A, Neuroscience, Cell biology, MAPK14, MAP2K7
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::754d7ca3b1fb9b5dd445506ce4502401
https://doi.org/10.1002/(sici)1096-9861(19980831)398:3<373::aid-cne6>3.0.co;2-x -
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المؤلفون: Thomas M. Engber, Shelley A Dennis, Patricia C. Contreras, Matthew S. Miller, Elizabeth J. Koury, Ratan V Bhat
المصدر: Neuroscience Letters. 241:95-98
مصطلحات موضوعية: Male, medicine.medical_specialty, Modafinil, Striatum, Amygdala, Supraoptic nucleus, Rats, Sprague-Dawley, Internal medicine, mental disorders, medicine, Animals, Benzhydryl Compounds, Wakefulness, Amphetamine, Neurons, Chemistry, Suprachiasmatic nucleus, General Neuroscience, Central nucleus of the amygdala, Brain, Immunohistochemistry, Rats, Endocrinology, medicine.anatomical_structure, nervous system, Hypothalamus, Central Nervous System Stimulants, Proto-Oncogene Proteins c-fos, Neuroscience, medicine.drug