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1
المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization
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2
المؤلفون: Frederick Sannajust, Jeffery J. Travis, Pierre Morissette, Christopher P. Regan, Patrick Fanelli, Kevin Fitzgerald, S. Wang, Pamela Gerenser
المصدر: Journal of Pharmacological and Toxicological Methods. 81:171-182
مصطلحات موضوعية: Male, Xylazine, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Guinea Pigs, hERG, Drug Evaluation, Preclinical, Torsades de pointes, In Vitro Techniques, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, QT interval, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Torsades de Pointes, Internal medicine, medicine, Animals, Anesthesia, Ketamine, cardiovascular diseases, Pharmacology, Proarrhythmia, Anesthetics, Dissociative, biology, business.industry, Safety pharmacology, Arrhythmias, Cardiac, Heart, medicine.disease, Long QT Syndrome, Concomitant, cardiovascular system, biology.protein, Cardiology, business, Adrenergic alpha-Agonists, circulatory and respiratory physiology, medicine.drug
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3
المؤلفون: Sebastian Polak, Blanca Rodriguez, Elisa Passini, Patrick Fanelli, Jin Zhai, Kevin Fitzgerald, Jeffrey Travis, Pierre Morissette, Anne S. Y. Chain, Frederick Sannajust, Christopher P. Regan
المصدر: Journal of Pharmacological and Toxicological Methods. 105:106804
مصطلحات موضوعية: Pharmacology, Guinea pig, medicine.medical_specialty, Arrhythmic risk, business.industry, Internal medicine, In silico, Qtc interval prolongation, Cardiology, Medicine, Toxicology, business
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4
المؤلفون: Kevin Fitzgerald, Hillary Regan, Patrick Fanelli, Jeffrey Travis, Pierre Morissette, Pamela Gerenser, Sylvain Bernasconi, Christopher P. Regan, Frederick Sannajust
المصدر: Journal of Pharmacological and Toxicological Methods. 75:52-61
مصطلحات موضوعية: Male, Xylazine, Guinea Pigs, hERG, Toxicology, QT interval, Electrocardiography, Heart Rate, Phenethylamines, Heart rate, medicine, Animals, Repolarization, Ivabradine, Ketamine, Ephedrine, Pharmacology, Sulfonamides, biology, business.industry, Sotalol, Benzazepines, Long QT Syndrome, Anesthesia, Models, Animal, biology.protein, business, medicine.drug
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5
المؤلفون: Frederick Sannajust, Christopher P. Regan, Patrick Fanelli
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595
مصطلحات موضوعية: Pharmacology, Amplitude, Computer science, business.industry, ST segment, Pattern recognition, Artificial intelligence, Toxicology, business, Automated method
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6
المؤلفون: Patrick Fanelli, Shaun Gruver, Robert V. Brockway, Theodore Detwiler, Gary Miller, Frederick Sannajust, Tom Delahanty, Christopher P. Regan, Hillary Regan
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Internal medicine, Telemetry, medicine, Cardiology, Implant, Toxicology, business, Lead (electronics), Beagle
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7
المؤلفون: Shaun Gruver, Hillary Regan, Pierre Morissette, Patrick Fanelli, Frederick Sannajust, Theodore Detwiler, Christopher P. Regan
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Safety risk, business.industry, Internal medicine, medicine, Cardiology, Heart rate variability, Sensitivity (control systems), Baroreflex, Toxicology, business
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8
المؤلفون: Jin Zhai, Christopher P. Regan, Elisa Passini, Frederick Sannajust, Pierre Morissette, Patrick Fanelli, Blanca Rodriguez, Jeffrey Travis, Alfonso Bueno-Orovio, John Imredy, Spencer J. Dech
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595
مصطلحات موضوعية: Pharmacology, Arrhythmic risk, business.industry, In silico, Medicine, Computational biology, Toxicology, business, In vitro, Ion channel
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9
المؤلفون: Bharathi Balasubramanian, Pamela Gerenser, Frederick Sannajust, Blanca Rodriguez, Patrick Fanelli, Alfonso Bueno-Orovio, Elisa Passini, Pierre Morissette, Jeffrey Travis, Christopher P. Regan
المصدر: Journal of Pharmacological and Toxicological Methods. 93:144-145
مصطلحات موضوعية: Pharmacology, Arrhythmic risk, Chemistry, In silico, 02 engineering and technology, Toxicology, 01 natural sciences, 010305 fluids & plasmas, Guinea pig, Vanoxerine, In vivo, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, medicine, 020201 artificial intelligence & image processing, Ion channel, medicine.drug
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10
المؤلفون: Min Deng, Guillermo Fernandez, Frederick Sannajust, Brian Hange, William Cook, William Keller, Alema Galijatovic-Idrizbegovic, Maria I. Roman, Katherine Bustard, Alysia A. Chaves, Beth-Ann Rockafellow, Philippe Zitoun, Patrick Fanelli, Radu Munteanu
المصدر: Journal of Pharmacological and Toxicological Methods. 88:214
مصطلحات موضوعية: Pharmacology, Toxicology, Surface ecg, Computer science, System a