يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Patrick G. Pollard"', وقت الاستعلام: 0.75s تنقيح النتائج
  1. 1
    Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

    المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin

    المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334

    مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea0aa624d82cc9bc8f3cfa4bdb369
    https://doi.org/10.1016/j.bmcl.2011.02.090

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  2. 2
    Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

    المؤلفون: Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat

    المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3501-3505

    مصطلحات موضوعية: Male, Agonist, Quinuclidines, Time Factors, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, Eating, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aza Compounds, Bicyclic molecule, Chemistry, Penile Erection, digestive, oral, and skin physiology, Organic Chemistry, Small molecule, Rats, Microsomes, Liver, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec96b03aa1e5f2ba3d3c429b0a51544
    https://doi.org/10.1016/j.bmcl.2005.05.109

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  3. 3
    Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

    المؤلفون: William J. Martin, D. Euan MacIntyre, Ravi P. Nargund, Rubana N. Kalyani, Rui Tang, George A. Doss, Min K. Park, Alison M. Strack, Erin McGowan, Joseph M. Metzger, Charles Rosenblum, Randall R. Miller, Palucki Brenda, Qianping Peng, Arthur A. Patchett, Ralph A. Stearns, Patrick G. Pollard, Lex H.T. Van der Ploeg, Iyassu K. Sebhat, Constantin Tamvakopoulos, Cherrie Shepherd, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, Zhixiong Ye

    المصدر: Bioorganic & Medicinal Chemistry Letters. 15:171-175

    مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Mice, Dogs, Erectile Dysfunction, Piperidines, In vivo, Drug Discovery, medicine, Animals, Obesity, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, In vitro, Rats, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e9173e9b0b0823886380b760b7694a
    https://doi.org/10.1016/j.bmcl.2004.10.020

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  4. 4
    Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

    المؤلفون: Ravi P. Nargund, Ian J. Reynolds, Tung Fong, Christopher P. Regan, Cherrie Shepherd, David H. Weinberg, Zhixiong Ye, Joseph J. Lynch, Patrick G. Pollard, Alison M. Strack

    المصدر: Pharmacology. 83(1)

    مصطلحات موضوعية: Agonist, Male, endocrine system, medicine.medical_specialty, animal structures, medicine.drug_class, Administration, Oral, CHO Cells, Neuroprotection, Piperazines, Cricetulus, Melanocortin receptor, Piperidines, Internal medicine, Cricetinae, Medicine, Animals, Humans, Rats, Wistar, Stroke, Pharmacology, integumentary system, biology, business.industry, Infarction, Middle Cerebral Artery, General Medicine, biology.organism_classification, medicine.disease, Rats, Disease Models, Animal, Endocrinology, Neuroprotective Agents, Reperfusion Injury, Injections, Intravenous, Receptor, Melanocortin, Type 4, Melanocortin, Dizocilpine Maleate, business, Reperfusion injury, hormones, hormone substitutes, and hormone antagonists, Hormone

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712e2c8901dac00409de69f28d2e5ed4
    https://pubmed.ncbi.nlm.nih.gov/19052481

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