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1
المؤلفون: Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem
المصدر: Journal of Medicinal Chemistry. 60:1946-1958
مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, In silico, medicine.medical_treatment, 010402 general chemistry, 01 natural sciences, 03 medical and health sciences, Catalytic Domain, Complement Factor D, Drug Discovery, Hydrolase, medicine, Humans, Protease Inhibitors, Serine protease, Protease, Molecular Structure, biology, Chemistry, 0104 chemical sciences, Complement system, 030104 developmental biology, Biochemistry, Drug Design, biology.protein, Alternative complement pathway, Molecular Medicine, Factor D
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2
المؤلفون: Eva Altmann, Paul Erbel, Martin Renatus, Michael Schaefer, Anita Schlierf, Adelaide Druet, Laurence Kieffer, Mickael Sorge, Keith Pfister, Ulrich Hassiepen, Matthew Jones, Simon Ruedisser, Daniela Ostermeier, Bruno Martoglio, Anne B. Jefferson, Jean Quancard
المصدر: Angewandte Chemie. 129:1314-1317
مصطلحات موضوعية: General Medicine
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3
المؤلفون: Jayachandran N. Kizhakkedathu, Joerg Eder, Theo Klein, Paul Erbel, Sohyeong Kang, Frederic Villard, Rosa Viner, Frédéric Bornancin, Christopher M. Overall, Martin Renatus, Jean Quancard, Rene Hersperger, Jutta Blank, John J. Priatel, Michael Blank, Achim Schlapbach, Shan-Yu Fung, Stuart E. Turvey, Laura Israel, Nicola Hughes
المساهمون: Clinical Chemistry
المصدر: Nature Chemical Biology, 15(3), 304-+. Nature Publishing Group
مصطلحات موضوعية: Male, MAP Kinase Signaling System, medicine.medical_treatment, Allosteric regulation, Cleavage (embryo), 03 medical and health sciences, Hydrolase, medicine, Humans, Lymphocytes, Molecular Biology, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Protease, Chemistry, 030302 biochemistry & molecular biology, Immunologic Deficiency Syndromes, NF-kappa B, Cell Biology, Paracaspase, Cell biology, Neoplasm Proteins, MALT1, Gene Expression Regulation, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Signal transduction, Signal Transduction
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4
المؤلفون: Arnaud Decock, Paul Erbel, Mickael Sorge, Rene Beerli, Samu Melkko, Frédéric Bornancin, Bertran Rubi, Oliver Simic, Catherine H. Régnier, Carole Pissot-Soldermann, Martin Renatus, Jean Quancard, Achim Schlapbach, Langlois Jean Baptiste Georges Armand, Nikolaus Schiering, Nicola Hughes, Marina Tintelnot-Blomley, Karen Beltz, Frederic Villard, Nicole Buschmann, Carsten Spanka, Christian Wiesmann
المصدر: Advanced Therapeutics. 3:2000078
مصطلحات موضوعية: Pharmacology, Protease, Stereochemistry, Chemistry, Drug discovery, medicine.medical_treatment, Biochemistry (medical), Allosteric regulation, Pharmaceutical Science, Medicine (miscellaneous), MALT1, medicine, Pharmacology (medical), Genetics (clinical)
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5
المؤلفون: Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:438-443
مصطلحات موضوعية: Adenain, Drug, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Viral Conjunctivitis, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Adenoviridae, Structure-Activity Relationship, Viral Proteins, Drug Discovery, medicine, Humans, Effective treatment, Protease Inhibitors, Molecular Biology, media_common, Binding Sites, Protease, Tetrapeptide, Chemistry, Organic Chemistry, Virology, Protein Structure, Tertiary, Molecular Docking Simulation, Cysteine Endopeptidases, HEK293 Cells, Drug Design, Molecular Medicine, Structure based, Protein Binding
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6
المؤلفون: Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin
المصدر: ACS Medicinal Chemistry Letters. 5:937-941
مصطلحات موضوعية: Adenain, Protease, Tetrapeptide, Chemistry, medicine.medical_treatment, Organic Chemistry, Drug Discovery, medicine, Structure based, Biochemistry, Cysteine protease, Combinatorial chemistry, Adenoviral infections
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7
المؤلفون: Simon Ruedisser, Bruno Martoglio, Michael Schaefer, Paul Erbel, Laurence Kieffer, Ulrich Hassiepen, Anita Schlierf, Martin Renatus, Mickael Sorge, Daniela Ostermeier, Adelaide Druet, Jean Quancard, Matthew Jones, Anne B. Jefferson, Keith B. Pfister, Eva Altmann
المصدر: Angewandte Chemie (International ed. in English). 56(5)
مصطلحات موضوعية: 0301 basic medicine, Indoles, NEDD8 Protein, Protein subunit, medicine.medical_treatment, Cleavage (embryo), Crystallography, X-Ray, NEDD8, Catalysis, 03 medical and health sciences, Ubiquitin, Catalytic Domain, medicine, Fluorescence Resonance Energy Transfer, Humans, COP9 signalosome, RNA, Small Interfering, S-Phase Kinase-Associated Proteins, Cell Proliferation, Metalloproteinase, Protease, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, COP9 Signalosome Complex, General Chemistry, HCT116 Cells, Small molecule, Molecular Docking Simulation, Protein Subunits, Zinc, 030104 developmental biology, Biochemistry, biology.protein, RNA Interference
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8
المؤلفون: Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao
المساهمون: Maibaum, Jürgen, Liao, Sha Mei, Vulpetti, Anna, Ostermann, Nil, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Sweeney, Aengus Mac, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, ANTONIO MARIA, Eder, Jörg, Anderson, Karen
المصدر: Nature chemical biology. 12(12)
مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Models, Molecular, medicine.medical_treatment, Complement Pathway, Alternative, Biology, Small Molecule Libraries, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protease, Innate immune system, Complement component 3, Dose-Response Relationship, Drug, Molecular Structure, Cell Biology, medicine.disease, Small molecule, Complement system, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, biology.protein, Factor D, Complement Factor D
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9
المؤلفون: Maxime Chaillet, Paul Erbel, Frederic Villard, Peggy Lefeuvre, Nikolaus Schiering, Allan D'Arcy, Siew Pheng Lim
المصدر: Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 2)
مصطلحات موضوعية: West Nile virus, viruses, Biophysics, High resolution, Biology, Dengue virus, Viral Nonstructural Proteins, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, Dengue fever, Structural Biology, Genetics, medicine, Humans, NS3, Serine Endopeptidases, virus diseases, Dengue Virus, Condensed Matter Physics, medicine.disease, Virology, Increasing risk, Cysteine Endopeptidases, Viral replication, Crystallization Communications, Multiprotein Complexes, Crystallization, Encephalitis
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10
المؤلفون: Subhash G. Vasudevan, Paul Erbel, Allan D'Arcy, Zheng Yin, Martin Renatus, Nikolaus Schiering, Ulrich Hommel, Thomas H. Keller, M. Kroemer, Siew Pheng Lim
المصدر: Nature structuralmolecular biology. 13(4)
مصطلحات موضوعية: Models, Molecular, Proteases, West Nile virus, Macromolecular Substances, viruses, medicine.medical_treatment, Substrate recognition, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Dengue fever, Structural Biology, medicine, Protease Inhibitors, Molecular Biology, NS3, Protease, Binding Sites, Serine Endopeptidases, virus diseases, Hydrogen Bonding, biochemical phenomena, metabolism, and nutrition, Dengue Virus, medicine.disease, Virology, Enzyme Activation, Oligopeptides, RNA Helicases