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1
المؤلفون: Fiona S. Lucas, Helen Susanne Price, John Andrew Corfield, Graham Webb, Steve B. Guntrip, Sean J. Hindley, Alan Naylor, Robert Gleave, Neil Mathews, C. Bountra, Hazel Player, Paul F. Lambeth, Richard M. Hall, Ian B. Campbell, Terry Brown, Andrew P. Blackaby, Joanne O. Wiseman, Kerry Browning, Paul John Beswick, Phillip J. Sidebottom, Nicholas L. Taylor
المصدر: Bioorganicmedicinal chemistry letters. 19(15)
مصطلحات موضوعية: Pyrimidine, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Biotransformation, Drug Discovery, Humans, Molecular Biology, Inflammation, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Organic Chemistry, Inflammatory pain, Enzyme inhibition, chemistry, Models, Chemical, Enzyme inhibitor, Cyclooxygenase 2, Drug Design, Lipophilicity, biology.protein, Molecular Medicine, Identification (biology), Cyclooxygenase
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2
المؤلفون: Paul F. Lambeth, Fiona S. Lucas, Richard Howard Green, Martin E. Swarbrick, Jeremy John Payne, Lee William Page, Malcolm Clive Carter, Paul John Beswick, Alexander J. Stevens, Sharon C Stratton, Neil Anthony Pegg, John Skidmore, Savvas Kleanthous, Alastair J. Stuart, Sue D. Collins, Sharon Bingham, John Andrew Corfield, Richard Stocker, Joanne O. Wiseman, C. David Hartley, Helen Susanne Price, Neil Mathews, Laura J. Chambers, Iain P. Chessell, Robert Gleave, Nick M. Clayton, Alan Naylor, C. Bountra
المصدر: Bioorganicmedicinal chemistry letters. 19(15)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Ether, Biochemistry, Chemical synthesis, Sulfone, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Drug Discovery, Animals, Humans, Sulfones, Amines, Molecular Biology, chemistry.chemical_classification, Inflammation, Trifluoromethyl, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Organic Chemistry, Brain, Neurodegenerative Diseases, Rats, Disease Models, Animal, Enzyme, Pyrimidines, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Drug Design, biology.protein, Molecular Medicine, Selectivity, Ethers
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3
المؤلفون: Hazel Player, John Andrew Corfield, Iain P. Chessell, Helen Susanne Price, Sharon C Stratton, Stephen Barry Guntrip, Neil Anthony Pegg, Elizabeth Pickup, Sue D. Collins, Terry Brown, Paul F. Lambeth, Kerry Browning, Sharon Bingham, Paul John Beswick, Alan Naylor, C. Bountra, Claudine Haslam, Ian B. Campbell, Nick M. Clayton, Alexander J. Stevens, Graham Murkit, Fiona S. Lucas, Joanne O. Wiseman, Neil Mathews
المصدر: Bioorganic and medicinal chemistry letters. 14(21)
مصطلحات موضوعية: Male, Clinical Biochemistry, Analgesic, Freund's Adjuvant, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, Biochemistry, Chemical synthesis, Pyridazine, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclooxygenase Inhibitors, Infusions, Intravenous, Molecular Biology, biology, Bicyclic molecule, Cyclooxygenase 2 Inhibitors, Organic Chemistry, Brain, Membrane Proteins, Arthritis, Experimental, Rats, Pyridazines, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, biology.protein, Molecular Medicine, Pyrazoles, Cyclooxygenase
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4
المؤلفون: Richard H. Green, Paul F. Lambeth
المصدر: Tetrahedron. 39:1687-1721
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::84011f47850c40d6841192a01b2d0107
https://doi.org/10.1016/s0040-4020(01)88677-4
