المؤلفون: Jonathan P. Hutchinson, Paul Rowland, Mark R. D. Taylor, Erica M. Christodoulou, Carl Haslam, Clare I. Hobbs, Duncan S. Holmes, Paul Homes, John Liddle, Damian J. Mole, Iain Uings, Ann L. Walker, Scott P. Webster, Christopher G. Mowat, Chun-wa Chung

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a

المؤلفون: Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e

المؤلفون: Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe

المصدر: Journal of Medicinal Chemistry. 65:633-664

مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Binding Sites, Aldehyde Oxidase, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Drug Delivery Systems, Liver, Drug Discovery, Quinazolines, Animals, Humans, Janus Kinase Inhibitors, Molecular Medicine, Administration, Intravenous, Female, Lung, Administration, Intranasal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765

المؤلفون: Gheorghe-Doru Roiban, Cyril Boudet, Paul Homes, Kristin K. Brown, Jiasheng Guo, Douglas E. Fuerst, Alison S. Dann, Andrew P. Fosberry, Christopher Morgan, Rebecca Splain, Peter W. Sutton, Katherine Joyce Honicker, Leigh Anne F. Ihnken

المصدر: Organic Process Research & Development. 21:1302-1310

مصطلحات موضوعية: Downstream processing, biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Aspergillus niger, Enantioselective synthesis, Epoxide, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Hydrolysis, chemistry, Organic chemistry, Halohydrin, Fermentation, Physical and Theoretical Chemistry, Epoxide hydrolase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b5316117ac33fa0f397c3d81dc1e0d07
https://doi.org/10.1021/acs.oprd.7b00179

المؤلفون: Duncan S. Holmes, Paul Homes, Chun-wa Chung, Ann Louise Walker, Jonathan P. Hutchinson, Erica Christodoulou, John Liddle, Christopher G. Mowat, Scott P. Webster, Iain Uings, Carl Haslam, Clare I. Hobbs, Damian J. Mole, Paul Rowland, Mark R D Taylor

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Hutchinson, J P, Rowland, P, Taylor, M R D, Christodoulou, E M, Haslam, C, Hobbs, C M, Holmes, D, Homes, P, Liddle, J, Mole, D J, Uings, I J, Walker, A L, Webster, S P, Mowat, C & Chung, C 2017, ' Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase ', Nature Communications, vol. 8, 15827 . https://doi.org/10.1038/ncomms15827
Nature Communications
'Nature Communications ', vol: 8, pages: 15827-1-15827-12 (2017)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Multiple Organ Failure, Science, Protein domain, General Physics and Astronomy, Flavin group, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Kynurenine 3-Monooxygenase, Protein Domains, Oxidoreductase, medicine, Escherichia coli, Sf9 Cells, Animals, Humans, Enzyme Inhibitors, chemistry.chemical_classification, Multidisciplinary, 030102 biochemistry & molecular biology, Chemistry, General Chemistry, Hydrogen Peroxide, Tryptophan Metabolism, medicine.disease, 3. Good health, 030104 developmental biology, Enzyme, Biochemistry, Pancreatitis, Molecular mechanism, Acute pancreatitis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7052eaed51497ed8d9f669cdc0a94bd
https://doaj.org/article/6a2d1e05cbf54050aa6e26f4834e4b9a

المؤلفون: Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul Homes, Karen Ingraham, Jason Pizzollo, Carol Shen

المصدر: Nature, Nature Communications. 6(1):1-13

الإتاحة: https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms10048.html

المؤلفون: Peter Francis, Bill Leavens, Michelle L. Heathcote, Melanie Leveridge, Chun-wa Chung, Paul Homes, Argyrides Argyrou, Jordi Munoz-Muriedas, Michelle Gee, Laura Williams, Stuart M. Baddeley, Sue Hutchinson, Anthony Shillings, Emma J. Jones, Angela Bridges

المصدر: SLAS Discovery. 17:39-48

مصطلحات موضوعية: Jumonji Domain-Containing Histone Demethylases, Pyridines, High-throughput screening, Drug Evaluation, Preclinical, Peptide, Mass spectrometry, Biochemistry, Mass Spectrometry, Epigenesis, Genetic, Substrate Specificity, Analytical Chemistry, Histone H3, Epigenetics, Enzyme Inhibitors, Histone Demethylases, chemistry.chemical_classification, Dose-Response Relationship, Drug, Lysine, Substrate (chemistry), Oxyquinoline, High-Throughput Screening Assays, Kinetics, Enzyme, chemistry, Molecular Medicine, Peptides, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557947806d65ab6979c82184961e81b9
https://doi.org/10.1177/1087057111416660

المؤلفون: Michael N. Gwynn, Jianzhong Huang, Martin Hibbs, Claus Spitzfaden, Jason Pizzollo, Haifeng Cui, Velupillai Srikannathasan, Robert Tanner, Karen A. Ingraham, Robert A. Stavenger, Pan F. Chan, Minghua Gu, Carol Shen, Paul Homes, Andrew J. Theobald, Andrew P. Fosberry, Anthony Shillings, Michael M. Hann, Benjamin D. Bax

المصدر: Nature Communications

مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Staphylococcus aureus, Moxifloxacin, General Physics and Astronomy, Antineoplastic Agents, Cleavage (embryo), 01 natural sciences, DNA gyrase, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Bacterial, medicine, Topoisomerase II Inhibitors, Etoposide, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Molecular Structure, biology, 010405 organic chemistry, Topoisomerase, General Chemistry, Anti-Bacterial Agents, 0104 chemical sciences, 3. Good health, chemistry, Biochemistry, DNA Gyrase, biology.protein, Topoisomerase-II Inhibitor, Antibacterial activity, DNA, Fluoroquinolones, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b4c3994d8361a48efe0cd59325b97
https://doi.org/10.1038/ncomms10048

المؤلفون: Robert H. Bates, Alfonso Mendoza, Joaquín Rullas, Joël Lelièvre, Chun Wa Chung, Ruth Casanueva, Sudagar S. Gurcha, Maria Santos Martinez-Martinez, Patrick J. Moynihan, Margarete Neu, Nicholas Cammack, Gurdyal S. Besra, Nicholas J. Loman, Jonathan A. G. Cox, Katherine A. Abrahams, Paul Homes, Marcus Bantscheff, Anthony Shillings, Gerard Drewes, Elena Jimenez-Navarro, Lluis Ballell, Matthew Axtman, Carolyn Selenski, Argyrides Argyrou, Monica Cacho Izquierdo, Iñigo Angulo-Barturen, Laurent Kremer, María José Rebollo-López, David Barros, Sonja Ghidelli-Disse

المصدر: Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

مصطلحات موضوعية: 0301 basic medicine, Indazoles, Science, 030106 microbiology, Mutant, Antitubercular Agents, General Physics and Astronomy, Microbial Sensitivity Tests, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Minimum inhibitory concentration, Mice, Bacterial Proteins, In vivo, 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase, Drug Resistance, Bacterial, Animals, Tuberculosis, Pulmonary, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Drug discovery, General Chemistry, biology.organism_classification, Molecular biology, In vitro, 3. Good health, Mice, Inbred C57BL, Enzyme, Biochemistry, chemistry, Biological target, Female

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bc616023998dc8cdc5fc5ed68a4c7e
https://pubmed.ncbi.nlm.nih.gov/27581223

المؤلفون: Ian Churcher, Sarah E. Smith, Ryan P. Bingham, Clare I. Hobbs, Donald O. Somers, Eric Boursier, Chun Wa Chung, Charlène Fournier, Yoshiaki Washio, Peter Francis, Claus Spitzfaden, Iain H. Reid, Stephen D. Pickett, Sophie M. Bertrand, Graham L. Simpson, Andrew N. Hobbs, Klára Valkó, Laura A. Gummer, Robert J. Young, Nicolas Ancellin, Craig Jamieson, Colin J. Suckling, Anne Bénédicte Boullay, Lisa A. Sloan, Kenny Herry, Paul S. Carter, Nerina Dodic, Paul Homes, Edwige Nicodeme, Jennifer A. Borthwick, Benjamin Beaufils, Marie Helene Fouchet

المصدر: Journal of medicinal chemistry. 58(18)

مصطلحات موضوعية: Models, Molecular, Branched chain aminotransferase, Pyrimidinones, Crystallography, X-Ray, Mitochondrial Proteins, Structure-Activity Relationship, Valine, Leucine, Drug Discovery, Adipocytes, Structure–activity relationship, Transferase, Animals, Humans, Isoleucine, Transaminases, chemistry.chemical_classification, Mice, Inbred BALB C, Ligand efficiency, Chemistry, Molecular biology, Amino acid, Mice, Inbred C57BL, Biochemistry, Molecular Medicine, Pyrazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce49f6995b13621d1b99ef02fe9002a
https://pubmed.ncbi.nlm.nih.gov/26339805