المؤلفون: Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier, Andreas Boettcher, Jacob Peter Brady, Michael Hediger, Sylvie Lehmann, Elke Koch, Anke Blechschmidt, Rina Yamamoto, Valentina Tundo Dottorello, Sandra Haenni-Holzinger, Christian Kaiser, Philipp Lehr, Andreas Lingel, Luca Mureddu, Christian Schleberger, Jutta Blank, Paul Ramage, Felix Freuler, Joerg Eder, Frédéric Bornancin

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/045a20bdd9464a2d8a11a51d75b0961e

المؤلفون: Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams

المصدر: Journal of Medicinal Chemistry. 63:5697-5722

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870

المؤلفون: Dean F. Rigel, Gary M. Coppola, Frederic Villard, Li Fan, Muneto Mogi, Emma Cody, Nikolaus Schiering, Guiqing Liang, Christian Wiesmann, Arco Y. Jeng, Yongjin Gong, Jing Liu, Paul Ramage, Fumin Fu, Alan D. Neubert, Yuki Iwaki, Allan D'Arcy, Qian Liu, Wei Chen, Jennifer Leung-Chu, Robert Sun, Rajeshri Ganesh Karki, Frederic Cumin, Toshio Kawanami, Gary Michael Ksander, Sara Ingles, Michael E. Beil

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Biphenyl, Drug, 010405 organic chemistry, media_common.quotation_subject, fungi, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, Sacubitril, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Valsartan, chemistry, Drug Discovery, Hydrolase, medicine, Structure–activity relationship, Neprilysin, Active metabolite, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2573c39ef5000dc9e148109a83e4e51
https://doi.org/10.1021/acsmedchemlett.9b00578

المؤلفون: Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein

المصدر: Journal of medicinal chemistry. 63(15)

مصطلحات موضوعية: Drug, Male, Proteases, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Factor XIa, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, Complement Factor D, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, 030304 developmental biology, ADME, media_common, Serine protease, 0303 health sciences, Protease, biology, Chemistry, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Coagulation, biology.protein, Molecular Medicine, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603

المؤلفون: Meike Scharenberg, Serge Côté, Carsten Krantz, Craig T. Basson, Keith DiPetrillo, Stefan Ewert, Janeen M Salter, Brian Stoll, Geraldine Horny, Simone Schleeger, Yu-Hsin Chiu, Julie DeGagne, Peter Hoffmann, Andreas Hein, Jianying Yu, Peter McCormack, Zhiping Chen, Paul Ramage, Nikolaus Schiering, Frederic Villard, Yasser Khder, Samu Melkko, Jörg Eder, Ulrich Hassiepen, Yiming Zhang, Lionel Muller, Xueming Huang, Robert J. A. Frost, Kenneth Kulmatycki, Alexander W. Koch, David Louis Feldman

المصدر: Blood. 133(13)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, medicine.drug_class, Immunology, 030204 cardiovascular system & hematology, Pharmacology, Antibodies, Monoclonal, Humanized, Biochemistry, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Zymogen, Antithrombotic, Medicine, Animals, Humans, Blood Coagulation, Factor XI, medicine.diagnostic_test, business.industry, Anticoagulant, Anticoagulants, Thrombosis, Cell Biology, Hematology, Middle Aged, Mice, Inbred C57BL, Molecular Docking Simulation, Macaca fascicularis, 030104 developmental biology, Coagulation, Hemostasis, Immunoglobulin G, Anticoagulant Agent, Female, business, Fibrinolytic agent, Partial thromboplastin time

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f8d1cd3f39c4c75c6b009bf317a08d
https://pubmed.ncbi.nlm.nih.gov/30923107

المؤلفون: Paul Ramage, Hermann Gram, Mauro Zurini, Jean-Michel Rondeau

المصدر: mAbs. 7:1151-1160

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Interleukin-1beta, Immunology, Glutamic Acid, Plasma protein binding, Cross Reactions, Antibodies, Monoclonal, Humanized, Crystallography, X-Ray, Monoclonal antibody, Binding, Competitive, Epitope, law.invention, Epitopes, Mice, Species Specificity, Antibody Specificity, law, Report, medicine, Animals, Humans, Immunology and Allergy, Binding site, biology, Antibodies, Monoclonal, Receptors, Interleukin-1, Callithrix, Antibodies, Neutralizing, Virology, Molecular biology, Protein Structure, Tertiary, Rats, Canakinumab, biology.protein, Recombinant DNA, Macaca, Paratope, Rabbits, Antibody, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e808ab9c1bae8f913f43f26ae22ddf3
https://doi.org/10.1080/19420862.2015.1081323

المؤلفون: Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:438-443

مصطلحات موضوعية: Adenain, Drug, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Viral Conjunctivitis, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Adenoviridae, Structure-Activity Relationship, Viral Proteins, Drug Discovery, medicine, Humans, Effective treatment, Protease Inhibitors, Molecular Biology, media_common, Binding Sites, Protease, Tetrapeptide, Chemistry, Organic Chemistry, Virology, Protein Structure, Tertiary, Molecular Docking Simulation, Cysteine Endopeptidases, HEK293 Cells, Drug Design, Molecular Medicine, Structure based, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3777095530490cc9447027eeafc558
https://doi.org/10.1016/j.bmcl.2014.12.057

المؤلفون: Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin

المصدر: ACS Medicinal Chemistry Letters. 5:937-941

مصطلحات موضوعية: Adenain, Protease, Tetrapeptide, Chemistry, medicine.medical_treatment, Organic Chemistry, Drug Discovery, medicine, Structure based, Biochemistry, Cysteine protease, Combinatorial chemistry, Adenoviral infections

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c6b52f270b5d23e3714c30285f506a
https://doi.org/10.1021/ml500224t

المؤلفون: Claude Logel, Christian Wiesmann, Nikolaus Schiering, Frederic Villard, Frederic Cumin, Rajeshri Ganesh Karki, Gary Michael Ksander, Paul Ramage, Allan D'Arcy, Muneto Mogi

المصدر: Scientific Reports

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Conformational change, Stereochemistry, Tetrazoles, 030204 cardiovascular system & hematology, Crystallography, X-Ray, Article, Sacubitril, 03 medical and health sciences, 0302 clinical medicine, Non-competitive inhibition, Protein Domains, Catalytic Domain, medicine, Humans, Moiety, Enzyme Inhibitors, Neprilysin, Active metabolite, Multidisciplinary, biology, Chemistry, Aminobutyrates, Biphenyl Compounds, fungi, Active site, Hydrogen Bonding, Prodrug, Drug Combinations, 030104 developmental biology, Biochemistry, biology.protein, Valsartan, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a96206edf4381cbd113df5e98586a9
https://doi.org/10.1038/srep27909

المؤلفون: Annette Haacke, Gabriele Fendrich, Paul Ramage, Martin Geiser

المصدر: Protein Expression and Purification. 64:185-193

مصطلحات موضوعية: Protein Folding, biology, Kinase, Phosphotransferases, GroES, Protein Engineering, GroEL, Mass Spectrometry, Recombinant Proteins, Receptor tyrosine kinase, SH3 domain, Protein Structure, Tertiary, Solubility, Biochemistry, CDC37, Chaperone (protein), Chromatography, Gel, Escherichia coli, biology.protein, CLPB, Molecular Chaperones, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbe84cfbabdb445011a393b4cf0fbb3
https://doi.org/10.1016/j.pep.2008.10.022