-
1
المؤلفون: Rachel Fearns, Qin Yu, Michael Foley, Paul Robert Fleming, Jeremy R. Duvall, Barbara Ludeke, Christina Scherer, Carol A. Mulrooney, Michelle Palmer, Maurice D. Lee, Karthick Vishwanathan, Sarah M. McLeod, Lynn VerPlank, Sebastian T. Le Quement
المصدر: Antiviral Research. 131:19-25
مصطلحات موضوعية: 0301 basic medicine, viruses, Microbial Sensitivity Tests, Respiratory Syncytial Virus Infections, Virus Replication, Antiviral Agents, 01 natural sciences, Article, Virus, Viral Proteins, 03 medical and health sciences, Transcription (biology), Virology, Drug Discovery, Humans, Replicon, Respiratory system, Polymerase, Pharmacology, biology, Virus inhibitors, Hep G2 Cells, RNA-Dependent RNA Polymerase, Small molecule, High-Throughput Screening Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Viral replication, Respiratory Syncytial Virus, Human, biology.protein
-
2
المؤلفون: Jonathan A. Rose, Paul Robert Fleming, Adam B. Shapiro, David C. McKinney, Stewart L. Fisher, Rob Albert, Marshall Morningstar, Sushmita D. Lahiri
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:3301-3306
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Isozyme, Peptide substrate, Inhibitory Concentration 50, Structure-Activity Relationship, Broad spectrum, Drug Discovery, Escherichia coli, Humans, Methionyl Aminopeptidases, Potency, Enzyme Inhibitors, Molecular Biology, Drug discovery, Methionine aminopeptidase, Chemistry, Organic Chemistry, Azepines, Anti-Bacterial Agents, Enzyme Activation, Drug Design, Molecular Medicine
-
3
المؤلفون: Helen Plant, Robert E. McLaughlin, Melinda A. Foulk, Boudewijn L. M. de Jonge, Robert Albert, Scott D. Mills, Shubha Sriram, Paul Robert Fleming, Marian Preston, Jun Fan, Kathy MacCormack
المصدر: Antimicrobial Agents and Chemotherapy. 58:7264-7272
مصطلحات موضوعية: DNA, Bacterial, Recombinant Fusion Proteins, Green Fluorescent Proteins, Gene Expression, Biosensing Techniques, Biology, medicine.disease_cause, DNA gyrase, Bacterial genetics, Small Molecule Libraries, Inhibitory Concentration 50, chemistry.chemical_compound, Plasmid, Genes, Reporter, Escherichia coli, medicine, Pharmacology (medical), SOS response, Promoter Regions, Genetic, SOS Response, Genetics, Mechanisms of Action: Physiological Effects, Gene, Nucleic Acid Synthesis Inhibitors, Pharmacology, Escherichia coli Proteins, Membrane Transport Proteins, biology.organism_classification, Molecular biology, High-Throughput Screening Assays, Rec A Recombinases, Infectious Diseases, chemistry, DNA Gyrase, DNA, Bacteria, Bacterial Outer Membrane Proteins, Plasmids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4922a79174587b9296a62b62cd7d9bb0
https://doi.org/10.1128/aac.03475-14 -
4
المؤلفون: Ed T. Buurman, Melinda A. Foulk, Demetri T. Moustakas, David C. McKinney, Adam B. Shapiro, Jonathan A. Rose, Ning Gao, Paul Robert Fleming, Valerie A. Laganas
المصدر: Journal of Bacteriology. 194:5504-5512
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Drug Evaluation, Preclinical, RNA-dependent RNA polymerase, Microbial Sensitivity Tests, Biology, Microbiology, chemistry.chemical_compound, Transcription (biology), RNA polymerase, Drug Resistance, Bacterial, Escherichia coli, Enzyme Inhibitors, Molecular Biology, Polymerase, RNA, DNA-Directed RNA Polymerases, Articles, rpoB, Haemophilus influenzae, Molecular biology, Anti-Bacterial Agents, High-Throughput Screening Assays, chemistry, Myxopyronin, Mutation, biology.protein, Mutant Proteins, Rifampin, DNA, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf823bc526595de88c05307ef730c78
https://doi.org/10.1128/jb.01103-12 -
5
المؤلفون: Vadim Molodtsov, David C. McKinney, Paul Robert Fleming, Andrew D. Ferguson, Craig E. Masse, Charles J. Eyermann, Ed T. Buurman, Katsuhiko S. Murakami, Melinda A. Foulk
مصطلحات موضوعية: Models, Molecular, Conformational change, Protein Conformation, Chemistry Techniques, Synthetic, medicine.disease_cause, Crystallography, X-Ray, Article, chemistry.chemical_compound, Lactones, Structure-Activity Relationship, Protein structure, RNA polymerase, Drug Discovery, medicine, Structure–activity relationship, Humans, Binding site, Enzyme Inhibitors, Escherichia coli, Binding Sites, Chemistry, Escherichia coli Proteins, Blood Proteins, DNA-Directed RNA Polymerases, Haemophilus influenzae, High-Throughput Screening Assays, Myxopyronin, Biochemistry, Drug Design, Molecular Medicine, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2deaa42b28ed498ea60e8a5991c5254
https://europepmc.org/articles/PMC4658208/ -
6
المؤلفون: Makiko Mori, Paul Robert Fleming, James D. Whiteaker, Robert E. McLaughlin, Alita A. Miller, Sarah M. McLeod, Shin-ichiro Narita, Hajime Tokuda, Kathleen MacCormack
مصطلحات موضوعية: Gram-negative bacteria, Antifungal Agents, biology, Molecular Structure, Lipoproteins, Imidazoles, ATP-binding cassette transporter, Periplasmic space, Articles, Gene Expression Regulation, Bacterial, biology.organism_classification, Microbiology, Transport protein, Anti-Bacterial Agents, Protein Transport, Phenotype, Biochemistry, Lipoprotein transport, Candida albicans, Gram-Negative Bacteria, Mutation, Inner membrane, Bacterial outer membrane, Molecular Biology, Lipoprotein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd52fc4d780dd0ee33dcce9bf2b69e87
https://europepmc.org/articles/PMC4336340/ -
7
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:775-778
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mannich base, Biochemistry, Chemical synthesis, Piperazines, Adduct, Mannich Bases, DNA Adducts, Inhibitory Concentration 50, Jurkat Cells, chemistry.chemical_compound, Phenols, Drug Discovery, Humans, Phenol, Luciferases, Promoter Regions, Genetic, Molecular Biology, Cell growth, Organic Chemistry, Combinatorial chemistry, Actins, Piperazine, chemistry, Interleukin-2, Molecular Medicine, Selectivity, Lead compound
-
8
المؤلفون: Claire Sadler, Shubha Sriram, Naina Vinay Mudugal, Boudewijn L. M. de Jonge, Gajanan Shanbhag, David C. McKinney, Praveena Manjrekar, Paul Robert Fleming, Beena Paul, Charles J. Eyermann, Vasan K. Sambandamurthy, Anisha Ambady, Sudha Ravishankar, Parvinder Kaur, Murugan Chinnapattu, Anandkumar Raichurkar, Shahul Hameed P, Chaitanyakumar Kedari, Supreeth Guptha, Manoranjan Panda, Vaishali Humnabadkar
المصدر: ACS chemical biology. 9(10)
مصطلحات موضوعية: Microbial Sensitivity Tests, Biology, medicine.disease_cause, Biochemistry, Bacterial cell structure, Microbiology, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, medicine, Escherichia coli, Structure–activity relationship, Humans, Enzyme Inhibitors, Peptide Synthases, chemistry.chemical_classification, Alanine, Molecular Structure, General Medicine, biology.organism_classification, Uridine Diphosphate N-Acetylmuramic Acid, Anti-Bacterial Agents, Enzyme, Pyrimidines, chemistry, Models, Chemical, Pseudomonas aeruginosa, Molecular Medicine, Pyrazoles, Peptidoglycan, Efflux, Protein Kinases, Bacteria
-
9
المؤلفون: Douglas Ferguson, Hui Xiong, Qin Yu, Demetri T. Moustakas, Melinda A. Foulk, Dean G. Brown, Paul Robert Fleming, Dedong Wu, Jun Fan, Lisa Aschenbrenner, Minli Zhang, Kenneth D. Johnson, Choi-Lai Tiong-Yip
المصدر: Bioorganicmedicinal chemistry letters. 23(24)
مصطلحات موضوعية: medicine.drug_class, viruses, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Virus Replication, Biochemistry, Antiviral Agents, Virus, Microbiology, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Viral Proteins, RNA polymerase, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Polymerase inhibitor, Molecular Biology, Polymerase, biology, Organic Chemistry, Azepines, DNA-Directed RNA Polymerases, Virology, Respiratory Syncytial Viruses, Enzyme Activation, chemistry, Respiratory syncytial virus RNA, biology.protein, Molecular Medicine, Antiviral drug
-
10
المؤلفون: John I. Manchester, Jonathan A. Rose, Shanta Bist, Kenneth Gregory Hull, Daemian Dussault, Paul Robert Fleming, Georgine Ioannidis, Maria Uria-Nickelsen, P. Ann Boriack-Sjodin
المصدر: Bioorganicmedicinal chemistry letters. 22(15)
مصطلحات موضوعية: DNA Topoisomerase IV, Methicillin-Resistant Staphylococcus aureus, Indoles, medicine.drug_class, Topoisomerase IV, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Microbial Sensitivity Tests, Crystallography, X-Ray, Biochemistry, DNA gyrase, Structure-Activity Relationship, Antibiotic resistance, Bacterial Proteins, Drug Discovery, Drug Resistance, Bacterial, medicine, Structure–activity relationship, Topoisomerase II Inhibitors, Binding site, Enzyme Inhibitors, Molecular Biology, Adenosine Triphosphatases, Virtual screening, Aza Compounds, Binding Sites, biology, Chemistry, Organic Chemistry, Anti-Bacterial Agents, Protein Structure, Tertiary, DNA Gyrase, biology.protein, Molecular Medicine, Topoisomerase-II Inhibitor, Topoisomerase inhibitor