نتائج البحث - "Paula Grasberger"

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Abstract ND01: KSQ-4279: A first-in-class USP1 inhibitor for the treatment of cancers with homologous recombination deficiencies

المصدر: Cancer Research. 82:ND01-ND01

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a9539d68445d92dc285a006c95dfa078
https://doi.org/10.1158/1538-7445.am2022-nd01

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Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

المؤلفون: Royale Nichols, Jillian J Spinney, Michael Bieler, Katharine E. Black, Yufei Lin, Lida P. Hariri, Clemens K. Probst, Paul Nicklin, Benjamin D. Medoff, Lorena Pantano, Paula Grasberger, Peter Seither, David Wyatt, Daniela M. Santos, Gina Pronzati, Andrew M. Tager

المصدر: Am J Respir Cell Mol Biol

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Cytoplasm, Simvastatin, Pulmonary Fibrosis, Clinical Biochemistry, Mevalonic Acid, Cell Cycle Proteins, Bleomycin, Small Molecule Libraries, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, Fibrosis, Pulmonary fibrosis, medicine, Animals, Humans, Fibroblast, Molecular Biology, Original Research, Adaptor Proteins, Signal Transducing, Cell Nucleus, Hippo signaling pathway, biology, business.industry, YAP-Signaling Proteins, Cell Biology, Fibroblasts, medicine.disease, Phosphoproteins, medicine.anatomical_structure, chemistry, HMG-CoA reductase, biology.protein, Cancer research, Mevalonate pathway, Acyl Coenzyme A, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Biomarkers, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69e7ff705685e150c6c5d62f81c340b
https://europepmc.org/articles/PMC7110981/

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The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

المؤلفون: Katharine E. Black, Norihiko Sakai, Jillian J Spinney, Linlin Zhang, James K. Liao, Andrew M. Tager, David Lagares, Alicia Franklin, Benjamin D. Medoff, Rachel S. Knipe, Paula Grasberger, Patricia L. Brazee, Barry S. Shea, Clemens K. Probst

المصدر: American Journal of Respiratory Cell and Molecular Biology. 58:471-481

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Chemistry, Clinical Biochemistry, Cell Biology, Lung injury, medicine.disease, Actin cytoskeleton, 03 medical and health sciences, 030104 developmental biology, Fibrosis, Pulmonary fibrosis, medicine, Cancer research, ROCK1, ROCK2, Molecular Biology, Rho-associated protein kinase, Myofibroblast

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ce4d303cf64cbf0d2d2302e8cb238cfd
https://doi.org/10.1165/rcmb.2017-0075oc

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4

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

المصدر: Nature Medicine. 23:1405-1415

مصطلحات موضوعية: 0301 basic medicine, ADAM10, Ephrin-B2, Lung injury, Skin Diseases, Exocytosis, General Biochemistry, Genetics and Molecular Biology, Extracellular matrix, ADAM10 Protein, Mice, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Fibrosis, Animals, Medicine, Myofibroblasts, Lung, Cells, Cultured, Skin, Mice, Knockout, Fibroblast chemotaxis, business.industry, Membrane Proteins, General Medicine, Fibroblasts, medicine.disease, Idiopathic Pulmonary Fibrosis, 3. Good health, Mice, Inbred C57BL, Protein Transport, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Amyloid Precursor Protein Secretases, Wound healing, business, Myofibroblast

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01285500d33f5ebe19f9b770dc23c96f
https://doi.org/10.1038/nm.4419

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5

A High-Throughput Small Molecule Screen for YAP Inhibitors Identifies Statins as Inhibitors of Fibroblast Activation and Pulmonary Fibrosis

المؤلفون: Jillian J Spinney, G. Pronzati, Katharine E. Black, Benjamin D. Medoff, Clemens K. Probst, Lorena Pantano, Andrew M. Tager, Daniela M. Santos, David Wyatt, Y. Lin, R. Nichols, Paula Grasberger

المصدر: D17. TOWARDS THE NEXT IPF THERAPIES.

مصطلحات موضوعية: medicine.anatomical_structure, Chemistry, Pulmonary fibrosis, medicine, Cancer research, medicine.disease, Fibroblast, Throughput (business), Small molecule

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e3e854e2081b35965bd1be5d853986
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5878

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Fibrogenic Lung Injury Induces Non–Cell-Autonomous Fibroblast Invasion

المؤلفون: Paula Grasberger, Moisés Selman, David Lagares, Brian Mugo, Annie Pardo, Carol Feghali-Bostwick, Neil Ahluwalia, Andrew M. Tager

المصدر: American Journal of Respiratory Cell and Molecular Biology. 54:831-842

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Lung injury, Biology, Bleomycin, 03 medical and health sciences, Idiopathic pulmonary fibrosis, Cell Movement, Transforming Growth Factor beta, Pulmonary fibrosis, medicine, Animals, Humans, Fibroblast, Molecular Biology, Original Research, medicine.diagnostic_test, Fibroblast growth factor receptor 2, Chemotaxis, Growth factor, Lung Injury, Cell Biology, Transforming growth factor beta, Fibroblasts, respiratory system, medicine.disease, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Mice, Inbred C57BL, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Solubility, Gene Knockdown Techniques, Cancer research, biology.protein, Bronchoalveolar Lavage Fluid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3528b4080d6f945c6b4010c475ce45bc
https://doi.org/10.1165/rcmb.2015-0040oc

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7

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

المؤلفون: Jeremy Ryan, David Lagares, Joan Montero, Murray Baron, Anthony Letai, Tobias Kuehl, Patrick Bhola, Andrew M. Tager, Mohit Kapoor, Norihiko Sakai, Alba Santos, Paula Grasberger, Fei Liu, Daniel J. Tschumperlin, Clemens K. Probst, Xaralabos Varelas, Rod A. Rahimi

المصدر: Science Translational Medicine. 9

مصطلحات موضوعية: Male, 0301 basic medicine, Cell Survival, bcl-X Protein, Priming (immunology), Apoptosis, Mitochondrion, Mechanotransduction, Cellular, 03 medical and health sciences, chemistry.chemical_compound, Fibrosis, Animals, Humans, Medicine, Mechanotransduction, Myofibroblasts, Sulfonamides, Aniline Compounds, Scleroderma, Systemic, Navitoclax, business.industry, Dermis, General Medicine, medicine.disease, Biomechanical Phenomena, Extracellular Matrix, Mitochondria, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, Mitochondrial Membranes, Cancer research, biological phenomena, cell phenomena, and immunity, business, Wound healing, Myofibroblast, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb3587afefa929b0e6fa0eea00f5cf7
https://doi.org/10.1126/scitranslmed.aal3765

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Corrigendum: ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

المصدر: Nature medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145a1797e7cf452a5c3893a8df9a6bbb
https://pubmed.ncbi.nlm.nih.gov/29058717

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9

Targeting fibroblast durotaxis as novel anti-fibrotic therapy for IPF

المؤلفون: Andrew M. Tager, Paula Grasberger, David Lagares, Adam J. Engler

المصدر: QJM: An International Journal of Medicine.

مصطلحات موضوعية: Anti fibrotic, Durotaxis, medicine.anatomical_structure, business.industry, Cancer research, medicine, General Medicine, Fibroblast, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::666136a7531b7ab06cc66cf204c6f149
https://doi.org/10.1093/qjmed/hcw127.001

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P099 ROCK Isoforms ROCK 1 and ROCK 2 are Critical for the Development of Pulmonary Fibrosis in Several Different Cell Specific Mechanisms

المؤلفون: Paula Grasberger, Andrew M. Tager, Barry S. Shea, Alicia Franklin, Rachel S. Knipe, Neil Ahluwalia, James K. Liao, David Lagares, Clemens K. Probst

المصدر: QJM: An International Journal of Medicine.

مصطلحات موضوعية: Gene isoform, Kinase, macromolecular substances, General Medicine, Biology, medicine.disease, Actin cytoskeleton, Cell biology, Fibroblast migration, Endothelial stem cell, Pulmonary fibrosis, medicine, ROCK1, ROCK2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d2299521fc26691a44941e38a3854bb8
https://doi.org/10.1093/qjmed/hcw127.035

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