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المؤلفون: Jordan Gauthier, Nicolas Gazeau, Alexandre V. Hirayama, Joshua A. Hill, Vicky Wu, Aisling Cearley, Paula Perkins, Angela Kirk, Mazyar Shadman, Victor A. Chow, Ajay K. Gopal, Alexandria Hodges Dwinal, Staci Williamson, Jessie Myers, Andy Chen, Sarah Nagle, Brandon Hayes-Lattin, Levanto Schachter, David G. Maloney, Cameron J. Turtle, Mohamed L. Sorror, Richard T. Maziarz
المصدر: Blood
مصطلحات موضوعية: Lymphoma, B-Cell, Receptors, Chimeric Antigen, Clinical Trials, Phase I as Topic, T-Lymphocytes, Antigens, CD19, Immunology, Cell Biology, Hematology, Immunotherapy, Adoptive, Biochemistry, Clinical Trials, Phase II as Topic, Humans, Blood Commentary, Cytokine Release Syndrome, Retrospective Studies
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5c2ac72658e7e56c49f30fbb713a48
https://doi.org/10.1182/blood.2021014497 -
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المؤلفون: Paula Perkins, Chaitra S. Ujjani, Ryan D. Cassaday, Mazyar Shadman, Brian G. Till, Ryan C. Lynch, Cameron J. Turtle, Aisling Cearley, Qian Vicky Wu, Stephen D. Smith, Jenna M. Voutsinas, Lorena Panaite, Victor A. Chow, Angela Kirk, Ajay K. Gopal, David G. Maloney, Hans-Peter Kiem, Jordan Gauthier, Erin Mullane
المصدر: Blood. 136:1-2
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Cytopenia, business.industry, Immunology, Large-cell lymphoma, Cell Biology, Hematology, medicine.disease, Biochemistry, Internal medicine, medicine, In patient, business, After treatment
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::469af6bc16e0bb0bcabf479a7badf499
https://doi.org/10.1182/blood-2020-134816 -
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المؤلفون: Paula Perkins, Andy I. Chen, Jordan Gauthier, Cameron J. Turtle, Brandon Hayes-Lattin, Levanto Schachter, Jessie Myers, David G. Maloney, Aisling Cearley, Staci Williamson, Mazyar Shadman, Mohamed L. Sorror, Sarah J. Nagle, Angela Kirk, Richard T. Maziarz
المصدر: Journal of Clinical Oncology. 39:7532-7532
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, biology, business.industry, CD19, Antigen, Refractory, Internal medicine, biology.protein, Medicine, In patient, Car t cells, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::006f654c03f70f5f15f91261863474ac
https://doi.org/10.1200/jco.2021.39.15_suppl.7532 -
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المؤلفون: Paula Perkins, Ajay K. Gopal, Mazyar Shadman, Ryan C. Lynch, David G. Maloney, Jenna M. Voutsinas, Chaitra S. Ujjani, Lorena Panaite, Lorenzo Iovino, Brian G. Till, Stephen D. Smith, Angela Kirk, Cameron J. Turtle, Vicky Wu, Victor A. Chow, Aisling Cearley, Jordan Gauthier
المصدر: Transplantation and Cellular Therapy. 27:S344
مصطلحات موضوعية: Transplantation, medicine.anatomical_structure, Refractory, business.industry, Cancer research, medicine, Molecular Medicine, Immunology and Allergy, Cell Biology, Hematology, Car t cells, business, B cell
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المؤلفون: Aisling Cearley, Angela Kirk, Paula Perkins, David G. Maloney, Mazyar Shadman, Erin Mullane
المصدر: Journal of Clinical Oncology. 38:3024-3024
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, Immunotherapy, CD19, Internal medicine, biology.protein, Medicine, business, Cell lymphoma
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ecea0289ca16125d2d6e2c85b6caa5e5
https://doi.org/10.1200/jco.2020.38.15_suppl.3024 -
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المؤلفون: Gail L. Wrigley, Shaun M. Fillery, Barry M. Hayter, Paula Perkins, Jason Grant Kettle, Emma J. Williams, Peter Mark Smith, Mandy L. Crowther, Rebecca J. Burton, Peter Robins, Neal J. Fazakerley, Caroline Anne McMillan
المصدر: Tetrahedron Letters. 54:6900-6904
مصطلحات موضوعية: Chemistry, Reagent, Organic Chemistry, Drug Discovery, Regioselectivity, Buchwald–Hartwig amination, Biochemistry, Combinatorial chemistry, Chemical space, Amination
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المؤلفون: Rajesh Odedra, Sylvie S. Guichard, Philip J. Jewsbury, Abid Suleman, Christine M. Wood, Lorraine A. Hassall, Kevin Blades, Thomas M. McGuire, Pia Thommes, Xavier Jacq, Paula Perkins, Ian Hickson, Ken Page, J. Willem M. Nissink, Kevin Michael Foote, Kin Yip Tam, Shaun M. Fillery, Rebecca Broadhurst, Anna Cronin
المصدر: Journal of Medicinal Chemistry. 56:2125-2138
مصطلحات موضوعية: Models, Molecular, Radiosensitizer, Morpholines, Antineoplastic Agents, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Pharmacology, Crystallography, X-Ray, HeLa, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, IC50, biology, Chemistry, Drug discovery, biology.organism_classification, Xenograft Model Antitumor Assays, In vitro, Pyrimidines, Molecular Medicine, Female, Growth inhibition, HeLa Cells
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المؤلفون: Malcolm Anderson, Julie A. Tucker, Ross Overman, Kevin J. Embrey, Kevin Blades, M. Raymond V. Finlay, Alexander L. Breeze, Gary Fairley, Jon Winter, Claire Brassington, S. Joe Patel, Christine M. Chresta, Gail L. Wrigley, Loredana Spadola, Thorsten Nowak, Paul Faulder, Jason Grant Kettle, Paula Perkins, Jonathan Tart
المصدر: Journal of medicinal chemistry. 58(5)
مصطلحات موضوعية: Models, Molecular, GTP', Protein Conformation, Mutant, GTPase, medicine.disease_cause, Crystallography, X-Ray, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, Drug Discovery, medicine, Humans, HRAS, Binding site, Binding Sites, Molecular Structure, Chemistry, Biochemistry, Covalent bond, Mutation, Biophysics, Molecular Medicine, KRAS, Small molecule binding, SOS1 Protein, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Peter Ballard, Michael James, Daniel S. James, Peter D. Smith, Simon J. Brown, M. Raymond V. Finlay, Michael J. Waring, Paula Perkins, Andrew D. Campbell, Heather L. McFarland, David Perkins, Gordon S. Currie, Gillian M. Lamont, Graham Richmond, Matthew R. Box, David Whittaker, Mark J. Anderton, Richard A. Ward, Teresa Klinowska, Scott G. Lamont, Nicola Colclough, Stuart L. Wells, Darren Cross, Gail L. Wrigley, George B. Hill, Nathaniel G. Martin, Paul D. Kemmitt, Susan Ashton, Lorraine A. Hassall, Paul A. Bethel, Robert Hugh Bradbury, Sam Butterworth, Christopher G. Chorley, Martine J. Mellor, Matthew Grist, Jonathon P. Orme
المصدر: Journal of medicinal chemistry. 57(20)
مصطلحات موضوعية: Male, Lung Neoplasms, Antineoplastic Agents, Drug resistance, Chemistry Techniques, Synthetic, Pharmacology, medicine.disease_cause, T790M, Inhibitory Concentration 50, Mice, Carcinoma, Non-Small-Cell Lung, Drug Discovery, medicine, Animals, Humans, Rociletinib, Epidermal growth factor receptor, Lung cancer, Protein Kinase Inhibitors, EGFR inhibitors, Mutation, Acrylamides, Aniline Compounds, biology, Wild type, Rats, Inbred Strains, Middle Aged, medicine.disease, Xenograft Model Antitumor Assays, respiratory tract diseases, ErbB Receptors, Drug Resistance, Neoplasm, biology.protein, Molecular Medicine, Female
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10أخبار
المؤلفون: Paula Perkins; JANE FRYER
المصدر: Daily Mail; 3/17/2018, p50, 2p