يعرض 1 - 10 نتائج من 16 نتيجة بحث عن '"Pauline Yeo"', وقت الاستعلام: 0.96s تنقيح النتائج
  1. 1
    دورية أكاديمية
    First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug

    المؤلفون: Vincenzo Teneggi, Veronica Novotny‐Diermayr, Lay Hoon Lee, Maryam Yasin, Pauline Yeo, Kantharaj Ethirajulu, Sylvia Bong Hwa Gan, Stephanie E. Blanchard, Ranjani Nellore, Dhananjay N. Umrani, Roberto Gomeni, Darren Lim Wan Teck, Greg Li, Qing Shu Lu, Yang Cao, Alex Matter

    المصدر: Clinical and Translational Science, Vol 13, Iss 1, Pp 57-66 (2020)

    مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

    URL الوصول: https://doaj.org/article/17e8ef4d9a8f43f8922705a7b52f3953

    View record at Wiley Find this article in full text from ProQuest Full Text Finder
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  2. 2
    Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
    https://doi.org/10.1158/1535-7163.22485351.v1

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  3. 3
    Supplementary Table 2 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45515ad58f3fa654f42c307ee91c362b
    https://doi.org/10.1158/1535-7163.22485345

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  4. 4
    Supplementary Table 1 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26232b2120ba418d9671855d8e245c
    https://doi.org/10.1158/1535-7163.22485348.v1

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  5. 5
    Supplementary Table 3 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab078191ad592debcca47d0ad3279d38
    https://doi.org/10.1158/1535-7163.22485342.v1

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  6. 6
    Data from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd470f6ae571ff56fa8b9560145061
    https://doi.org/10.1158/1535-7163.c.6531900

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  7. 7
    Preclinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics

    المؤلفون: Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Mohammed Khalid Pasha, Liu Xin, Kantharaj Ethirajulu, Pauline Yeo, Venkatesh Pilla Reddy, Haishan Wang, Ramesh Jayaraman, Evelyn Goh, Lee Sun New

    المساهمون: Science in Healthy Ageing & healthcaRE (SHARE), Nanomedicine & Drug Targeting

    المصدر: Drug Metabolism and Disposition, 39(12), 2219-2232. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS

    مصطلحات موضوعية: Male, CLEARANCE, Pracinostat, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, PARAMETERS, chemistry.chemical_compound, Mice, Dogs, Pharmacokinetics, Cytochrome P-450 Enzyme System, Tandem Mass Spectrometry, ABSORPTION, Animals, Humans, HYDROXAMIC ACID, Rats, Wistar, ADME, ALLOMETRY, Volume of distribution, Mice, Inbred BALB C, CYP3A4, CYP1A2, IN-VITRO, CANCER, Bioavailability, Rats, Histone Deacetylase Inhibitors, PHASE-I, chemistry, DRUG-METABOLISM, Microsomes, Liver, Benzimidazoles, Female, Caco-2 Cells, Drug metabolism, Chromatography, Liquid

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b0b6298a6f10ad88fa704d6b4918a6
    https://doi.org/10.1124/dmd.111.041558

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  8. 8
    Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile

    المؤلفون: Dizhong Chen, Mui Ling Khoo, Joyce Wei Wei Chang, Kee Chuan Goh, Xin Liu, Anders Poulsen, Siok Kun Goh, Kay Lin Goh, Kanda Sangthongpitag, Niefang Yu, Lye Pek Ling, Zahid Bonday, Changyong Hu, Xukun Wang, Xiaofeng Wu, Brian Dymock, Hwee Hoon Khng, Eric T. Sun, Haishan Wang, Melvin Ng, Lijuan Fang, Ethirajulu Kantharaj, Weiping Deng, Jeanette Marjorie Wood, Ting Lu, Ken Chi Lik Lee, Pauline Yeo

    المصدر: Journal of Medicinal Chemistry. 54:4694-4720

    مصطلحات موضوعية: Benzimidazole, medicine.drug_class, Administration, Oral, Biological Availability, Mice, Nude, Quantitative Structure-Activity Relationship, Antineoplastic Agents, Histone Deacetylase 1, Pharmacology, Mice, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Potency, Rats, Wistar, ADME, chemistry.chemical_classification, Mice, Inbred BALB C, biology, Chemistry, Histone deacetylase inhibitor, Cytochrome P450, Stereoisomerism, In vitro, Rats, Histone Deacetylase Inhibitors, Isoenzymes, Enzyme, Microsomes, Liver, biology.protein, Molecular Medicine, Benzimidazoles, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c07c03162bfd202810c8090e495663
    https://doi.org/10.1021/jm2003552

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  9. 9
    SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer

    المؤلفون: Haishan Wang, Jeanette Marjorie Wood, V Novotny-Diermayr, Nina Sausgruber, Stefan Hart, Sven Pettersson, Ai Leng Liang, Gediminas Greicius, Kee Chuan Goh, Kanda Sangthongpitag, Pauline Yeo, Xiaofeng Wu, Kantharaj Ethirajulu, Chang Yong Hu, Yung Kiang Loh, Zahid Bonday, Hannes Hentze

    المصدر: Molecular Cancer Therapeutics. 9:642-652

    مصطلحات موضوعية: Cancer Research, Colorectal cancer, medicine.drug_class, Pracinostat, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Pharmacology, Biology, Hydroxamic Acids, Mice, chemistry.chemical_compound, Pharmacokinetics, Neoplasms, Tumor Cells, Cultured, medicine, Animals, Humans, Vorinostat, Mice, Inbred BALB C, Histone deacetylase inhibitor, Cancer, HCT116 Cells, medicine.disease, Xenograft Model Antitumor Assays, Bioavailability, Histone Deacetylase Inhibitors, Treatment Outcome, Oncology, chemistry, Female, Histone deacetylase, Colorectal Neoplasms, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014b97b256155503a8752a920b31ca0b
    https://doi.org/10.1158/1535-7163.mct-09-0689

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  10. 10
    First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease

    المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras

    المصدر: Journal of Medicinal Chemistry. 48:6779-6782

    مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
    https://doi.org/10.1021/jm050307e

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