المؤلفون: Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G; Department of Microbiology, Immunology, and Physiology , Meharry Medical College , 1005 Dr. DB Todd Jr. Blvd. , Nashville , Tennessee 37208 , United States., Villalta F; Department of Microbiology, Immunology, and Physiology , Meharry Medical College , 1005 Dr. DB Todd Jr. Blvd. , Nashville , Tennessee 37208 , United States., Lepesheva GI; Department of Biochemistry School of Medicine, Institute for Global Health , Vanderbilt University , 622A RRB, 2200 Pierce Avenue , Nashville , Tennessee 37232 , United States., Soeiro MNC

المصدر: ACS infectious diseases [ACS Infect Dis] 2019 Mar 08; Vol. 5 (3), pp. 365-371. Date of Electronic Publication: 2019 Jan 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: 14-alpha Demethylase Inhibitors/*administration & dosage , Chagas Disease/*drug therapy , Nitroimidazoles/*administration & dosage , Protozoan Proteins/*antagonists & inhibitors , Trypanocidal Agents/*administration & dosage , Trypanosoma cruzi/*drug effects , Trypanosoma cruzi/*enzymology, 14-alpha Demethylase Inhibitors/chemistry ; Animals ; Chagas Disease/parasitology ; Disease Models, Animal ; Drug Synergism ; Drug Therapy, Combination ; Humans ; Male ; Mice ; Nitroimidazoles/chemistry ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Sterol 14-Demethylase/chemistry ; Sterol 14-Demethylase/metabolism ; Trypanocidal Agents/chemistry ; Trypanosoma cruzi/chemistry

المؤلفون: Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., De Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Pavão BP; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Simões-Silva MR; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Demarque KC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Moreira OC; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Britto C; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Lepesheva GI; Department of Biochemistry, School of Medicine, Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Mar 24; Vol. 61 (4). Date of Electronic Publication: 2017 Mar 24 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: 14-alpha Demethylase Inhibitors/*pharmacology , Chagas Disease/*drug therapy , Cytochrome P-450 Enzyme System/*chemistry , Imidazoles/*pharmacology , Oxadiazoles/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, 14-alpha Demethylase Inhibitors/chemistry ; Animals ; Chagas Disease/immunology ; Chagas Disease/parasitology ; Cyclophosphamide/adverse effects ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Disease Models, Animal ; Drug Administration Schedule ; Female ; Gene Expression ; Humans ; Imidazoles/chemistry ; Immunosuppressive Agents/adverse effects ; Male ; Mice ; Models, Molecular ; Nitroimidazoles/pharmacology ; Oxadiazoles/chemistry ; Parasite Load ; Recurrence ; Survival Analysis ; Trypanocidal Agents/chemistry ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/growth & development

المؤلفون: Simões-Silva MR; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Nefertiti AS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., De Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Bahia MT; Laboratório de Doenças Parasitárias, Escola de Medicina & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Menna-Barreto RS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Pavão BP; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Green J; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Farahat AA; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Kumar A; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Boykin DW; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Jul 22; Vol. 60 (8), pp. 4701-7. Date of Electronic Publication: 2016 Jul 22 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Animals ; Cell Line ; Cell Nucleus/drug effects ; Cell Nucleus/parasitology ; Chagas Disease/drug therapy ; Chagas Disease/parasitology ; Cytoplasm/drug effects ; Cytoplasm/parasitology ; Mammals/parasitology ; Parasitic Sensitivity Tests/methods ; Phenotype

المؤلفون: Soeiro Mde N; Laboratório de Biologia Celular do IOC, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. soeiro@ioc.fiocruz.br, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Sep; Vol. 57 (9), pp. 4151-63. Date of Electronic Publication: 2013 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: 14-alpha Demethylase Inhibitors/*pharmacology , Chagas Disease/*drug therapy , Imidazoles/*pharmacology , Oxadiazoles/*pharmacology , Protozoan Proteins/*antagonists & inhibitors , Sterol 14-Demethylase/*metabolism , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, 14-alpha Demethylase Inhibitors/chemistry ; Animals ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Drug Resistance/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/ultrastructure ; Golgi Apparatus/drug effects ; Golgi Apparatus/ultrastructure ; Imidazoles/chemistry ; Male ; Mice ; Microscopy, Electron, Transmission ; Nitroimidazoles/pharmacology ; Oxadiazoles/chemistry ; Protozoan Proteins/metabolism ; Thiazoles/pharmacology ; Triazoles/pharmacology ; Trypanocidal Agents/chemistry ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/growth & development ; Trypanosoma cruzi/ultrastructure