المؤلفون: Pearce NM, Skyner R, Krojer T.

المصدر: Front. Mol. Biosci.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::445962d52263c207740af0e9599834a1

المؤلفون: Hutchins GH; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Kiehstaller S; Incircular B.V., 1081 HZ Amsterdam, the Netherlands., Poc P; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Lewis AH; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Oh J; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Sadighi R; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Pearce NM; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Department of Physics, Chemistry and Biology, SciLifeLab, Linköping University, 581 83 Linköping, Sweden., Ibrahim M; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Drienovská I; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Rijs AM; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Neubacher S; Incircular B.V., 1081 HZ Amsterdam, the Netherlands., Hennig S; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands., Grossmann TN; Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.; Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, the Netherlands.

المصدر: Chem [Chem] 2024 Feb 08; Vol. 10 (2), pp. 615-627. Date of Electronic Publication: 2024 Feb 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101688902 Publication Model: Electronic Cited Medium: Print ISSN: 2451-9294 (Print) NLM ISO Abbreviation: Chem Subsets: PubMed not MEDLINE

المؤلفون: Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Berlin, Germany., Wollenhaupt J; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Berlin, Germany., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA., Heine A; Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany., Klebe G; Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany., Krojer T; MAX IV Laboratory, Lund University, Lund, Sweden., Thunissen M; MAX IV Laboratory, Lund University, Lund, Sweden., Pearce NM; Department of Chemistry and Pharmaceutical Sciences, VU Amsterdam, Amsterdam, The Netherlands.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2022 Sep; Vol. 31 (9), pp. e4391.

نوع المنشور: Letter

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Proteins*/chemistry, Crystallography, X-Ray ; Ligands

المؤلفون: Wood TM; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University Universiteitsweg 99 3584 CG Utrecht The Netherlands., Zeronian MR; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands b.j.c.janssen@uu.nl., Buijs N; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl., Bertheussen K; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl., Abedian HK; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl., Johnson AV; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl., Pearce NM; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands b.j.c.janssen@uu.nl., Lutz M; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands b.j.c.janssen@uu.nl., Kemmink J; Faculty of Science and Engineering, University of Groningen 9747 AG Groningen The Netherlands., Seirsma T; Bacterial Cell Biology and Physiology Group, Swammerdam Institute for Life Sciences, University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands., Hamoen LW; Bacterial Cell Biology and Physiology Group, Swammerdam Institute for Life Sciences, University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands., Janssen BJC; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands b.j.c.janssen@uu.nl., Martin NI; Biological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.

المصدر: Chemical science [Chem Sci] 2022 Feb 21; Vol. 13 (10), pp. 2985-2991. Date of Electronic Publication: 2022 Feb 21 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Ploscariu N; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Burnley T; Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot OX11 0FA, United Kingdom., Gros P; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands., Pearce NM; Chemistry and Pharmaceutical Sciences, Free University of Amsterdam, Amsterdam, The Netherlands.

المصدر: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2021 Nov 01; Vol. 77 (Pt 11), pp. 1357-1364. Date of Electronic Publication: 2021 Oct 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7983 (Electronic) Linking ISSN: 20597983 NLM ISO Abbreviation: Acta Crystallogr D Struct Biol Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation*, Coronavirus 3C Proteases/*chemistry , SARS-CoV-2/*enzymology, Crystallography, X-Ray ; Humans

المؤلفون: Faheem M; Laboratório de Biofísica Molecular, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF 70910-900, Brazil.; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, SGAN 916 Módulo B Avenida W5 - Asa Norte, Brasília, DF, Brazil.; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K.; Department of Biological Sciences, National University of Medical Sciences, The Mall, Abid Majeed Rd, Rawalpindi, Punjab 46000, Pakistan., Fonseca Valadares N; Laboratório de Biofísica Molecular, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF 70910-900, Brazil., Brandão-Neto J; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K., Bellini D; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K.; MRC LMB, Francis Crick Avenue, Cambridge CB2 0QH, U.K., Collins P; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K., Pearce NM; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K.; Structural Genomics Consortium, Old Road Campus Research Build, Roosevelt Dr, Oxford OX3 7DQ, U.K., Bird L; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K., Roberta Torini J; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP 13563-120, Brazil., Owens R; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K., DMuniz Pereira H; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP 13563-120, Brazil., Von Delft F; Harwell Science and Innovation Campus, Fermi Ave, Didcot OX11 0DE, U.K.; Structural Genomics Consortium, Old Road Campus Research Build, Roosevelt Dr, Oxford OX3 7DQ, U.K.; Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa., Barbosa JARG; Laboratório de Biofísica Molecular, Departamento de Biologia Celular, Universidade de Brasília, Brasília, DF 70910-900, Brazil.; Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, SGAN 916 Módulo B Avenida W5 - Asa Norte, Brasília, DF, Brazil.

المصدر: The Biochemical journal [Biochem J] 2021 Oct 15; Vol. 478 (19), pp. 3655-3670.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , Purine-Nucleoside Phosphorylase/*chemistry , Purine-Nucleoside Phosphorylase/*metabolism , Pyridines/*metabolism , Pyrimidines/*metabolism , Schistosoma mansoni/*enzymology , Thiazoles/*metabolism, Animals ; Catalytic Domain ; Crystallization ; Crystallography, X-Ray/methods ; Dimethyl Sulfoxide/pharmacology ; Drug Evaluation, Preclinical/methods ; Models, Molecular ; Protein Conformation, alpha-Helical ; Purine-Nucleoside Phosphorylase/genetics ; Schistosomiasis mansoni/drug therapy ; Schistosomiasis mansoni/parasitology

المؤلفون: Pearce NM; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands. n.m.pearce@vu.nl.; Department of Chemistry and Pharmaceutical Sciences, VU Amsterdam, Amsterdam, The Netherlands. n.m.pearce@vu.nl., Gros P; Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

المصدر: Nature communications [Nat Commun] 2021 Sep 17; Vol. 12 (1), pp. 5493. Date of Electronic Publication: 2021 Sep 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation*, Coronavirus 3C Proteases/*chemistry , Macromolecular Substances/*chemistry , SARS-CoV-2/*enzymology, COVID-19 ; Cryoelectron Microscopy ; Humans ; Membrane Proteins/chemistry ; Oxidoreductases/chemistry ; Protein Conformation

المؤلفون: Wendt M; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Bellavita R; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands.; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Gerber A; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Efrém NL; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., van Ramshorst T; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Pearce NM; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Davey PRJ; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Everard I; Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Vazquez-Chantada M; Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Chiarparin E; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Grieco P; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Hennig S; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Grossmann TN; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, Amsterdam, The Netherlands.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jun 14; Vol. 60 (25), pp. 13937-13944. Date of Electronic Publication: 2021 May 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic/*pharmacology , Peptides/*pharmacology , beta Catenin/*antagonists & inhibitors, Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Models, Molecular ; Peptides/chemistry ; Wnt Signaling Pathway/drug effects ; beta Catenin/metabolism

المؤلفون: Douangamath A; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Powell A; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Fearon D; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Collins PM; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Talon R; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus; Structural Genomics Consortium, University of Oxford., Krojer T; Structural Genomics Consortium, University of Oxford; Centre for Medicines Discovery, University of Oxford., Skyner R; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Brandao-Neto J; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Dunnett L; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Dias A; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus., Aimon A; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus; Structural Genomics Consortium, University of Oxford., Pearce NM; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Structural Genomics Consortium, University of Oxford., Wild C; Structural Genomics Consortium, University of Oxford; Oxford Protein Informatics Group, Department of Statistics, Oxford University., Gorrie-Stone T; Diamond Light Source Ltd, Harwell Science and Innovation Campus., von Delft F; Diamond Light Source Ltd, Harwell Science and Innovation Campus; Research Complex at Harwell, Harwell Science and Innovation Campus; Structural Genomics Consortium, University of Oxford; Centre for Medicines Discovery, University of Oxford; Department of Biochemistry, University of Johannesburg; frank.von-delft@diamond.ac.uk.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2021 May 29 (171). Date of Electronic Publication: 2021 May 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Crystallography, X-Ray/*methods , Drug Discovery/*methods , Proteins/*chemistry, Humans

المؤلفون: Oosterheert W; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Xenaki KT; Department of Biology, Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Neviani V; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Pos W; uniQure Biopharma, Amsterdam, The Netherlands., Doulkeridou S; Department of Biology, Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Manshande J; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Pearce NM; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Kroon-Batenburg LM; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Lutz M; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands., van Bergen En Henegouwen PM; Department of Biology, Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Gros P; Department of Chemistry, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands p.gros@uu.nl.

المصدر: Life science alliance [Life Sci Alliance] 2020 Sep 21; Vol. 3 (11). Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

مواضيع طبية MeSH: Tetraspanin 29/*metabolism , Tetraspanin 29/*ultrastructure, Antigens, CD/chemistry ; Antigens, CD/metabolism ; Antigens, CD/ultrastructure ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cell Membrane/metabolism ; Humans ; Membrane Glycoproteins/chemistry ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Membrane Proteins/ultrastructure ; Tetraspanin 28/metabolism ; Tetraspanin 28/ultrastructure ; Tetraspanin 29/physiology ; Tetraspanins/metabolism ; Tetraspanins/physiology ; Tetraspanins/ultrastructure ; Transcription Factors/metabolism