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1
المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
المصدر: ChemMedChem. 8:1295-1313
مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life
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2
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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3
المؤلفون: Kevin P. Quinn, Marc Adler, Gary Probst, Albert W. Garofalo, Anh P. Truong, Danny Tam, Erich Goldbach, Danielle L. Aubele, Maurizio Franzini, David Chian, Grace Kwong, Xiaocong M. Ye, Zhao Ren, Hing L. Sham, Lany Ruslim, Pearl Tanaka, Elizabeth F. Brigham, Ruth Motter
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1974-1977
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Protein kinase R, nervous system diseases, HEK293 Cells, Mutation, Quinolines, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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4
المؤلفون: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
المصدر: Journal of medicinal chemistry. 56(13)
مصطلحات موضوعية: Male, Time Factors, Gene Expression, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Dogs, Drug Stability, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, RNA, Messenger, Enzyme Inhibitors, Homeodomain Proteins, Sulfonamides, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Rats, Models, Chemical, Area Under Curve, Drug Design, Microsomes, Liver, Quinolines, Pyrazoles, Transcription Factor HES-1, Amyloid Precursor Protein Secretases, Heterocyclic Compounds, 3-Ring
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5
المؤلفون: Paul Beroza, Michael P. Bova, Jennifer K. Hoffman, Jennifer Sealy, Heather Zhang, Marcelle Bergeron, Linnea Diep, Danny Tam, Ruth Motter, Zhao Ren, R. Jeffrey Neitz, Danielle L. Aubele, Kent Fitzgerald, Michael Ye, Wayman Chan, Pearl Tanaka, Deepal Pandya, Donald J. Fauss, Andrei W. Konradi, John P. Anderson, Roy K. Hom, Dean R. Artis, Hing L. Sham, Robert A. Galemmo, George Tonn, Jeanne Baker, Lany Ruslim, Yong L. Zhu, Anh P. Truong, Michael S. Dappen, Simeon Bowers
المصدر: Bioorganicmedicinal chemistry letters. 23(9)
مصطلحات موضوعية: Parkinson's disease, Clinical Biochemistry, Substituent, Pharmaceutical Science, Administration, Oral, Cell Cycle Proteins, Polo-like kinase, Pharmacology, Protein Serine-Threonine Kinases, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Alpha-synuclein, Chemistry, Pteridines, Organic Chemistry, Brain, Highly selective, medicine.disease, Rats, medicine.anatomical_structure, Orally active, HEK293 Cells, Cerebral cortex, Drug Design, Microsomes, Liver, Molecular Medicine, Selectivity, Half-Life
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6
المؤلفون: Thomas I. F. H. Cremers, Robert Brendza, Ruth Motter, Robert Freije, Marieke G. C. van der Hart, Isaac Veinbergs, Lisa Yu, Harm Kooijker, Pearl Tanaka, Gunnar Flik
المصدر: Alzheimer's & Dementia. 7
مصطلحات موضوعية: Microdialysis, Amyloid β, Physiological significance, Epidemiology, Chemistry, Health Policy, Substrate (chemistry), Cleavage (embryo), Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Biophysics, Potency, Neurology (clinical), Geriatrics and Gerontology, Push pull, Gamma secretase
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7
المؤلفون: Karen Khan, Terry Guido, Daniel K. Ness, Chris Nishioka, Elizabeth F. Brigham, Kevin P. Quinn, Pearl Tanaka, Ruth Motter, Dora Kholodenko, Ferdie Soriano, Dora Games, Sally Schroeter, Erich Goldbach
المصدر: Alzheimer's & Dementia. 6
مصطلحات موضوعية: Epidemiology, business.industry, Health Policy, P3 peptide, Disease, Vascular amyloid, Biochemistry of Alzheimer's disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Parenchyma, Cancer research, Medicine, Neurology (clinical), Geriatrics and Gerontology, business, Beta (finance), Gamma secretase
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