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المؤلفون: van Dongen MJP; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands. mvandon@its.jnj.com wilson@scripps.edu.; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Juraszek J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lawson E; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Brandenburg B; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Schmitz F; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Schepens WBG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Stoops B; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., van Diepen HA; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Jongeneelen M; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Tang C; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Vermond J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., van Eijgen-Obregoso Real A; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Blokland S; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Garg D; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Goutier W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lanckacker E; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Klap JM; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Peeters DCG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Wu J; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Buyck C; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Jonckers THM; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roymans D; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roevens P; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Vogels R; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Koudstaal W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Friesen RHE; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Raboisson P; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Dhanak D; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Goudsmit J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. mvandon@its.jnj.com wilson@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

المصدر: Science (New York, N.Y.) [Science] 2019 Mar 08; Vol. 363 (6431).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science

مواضيع طبية MeSH: Antibodies, Neutralizing/*chemistry , Biomimetic Materials/*pharmacology , Influenza A Virus, H1N1 Subtype/*drug effects , Influenza, Human/*prevention & control , Piperazines/*pharmacology , Pyridines/*pharmacology , Tetrazoles/*pharmacology , Viral Fusion Protein Inhibitors/*pharmacology , Virus Internalization/*drug effects, Administration, Oral ; Animals ; Biomimetic Materials/administration & dosage ; Biomimetic Materials/pharmacokinetics ; Bronchi/virology ; Cells, Cultured ; Dogs ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Madin Darby Canine Kidney Cells ; Mice ; Piperazines/administration & dosage ; Piperazines/pharmacokinetics ; Pyridines/administration & dosage ; Pyridines/pharmacokinetics ; Respiratory Mucosa/virology ; Tetrazoles/administration & dosage ; Tetrazoles/pharmacokinetics ; Viral Fusion Protein Inhibitors/administration & dosage ; Viral Fusion Protein Inhibitors/pharmacokinetics