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1
المؤلفون: Christian Voitenleitner, Huichang Zhang, Renae M. Crosby, Kirsten M. Kahler, Feng Wang, John F. Miller, Elizabeth M. Turner, Daniel J. Price, Jing Fang, Andrew Maynard, Vincent W.-F. Tai, Katrina L. Creech, Andrew J. Peat, J. Brad Shotwell, Shawn P. Williams, Amanda Mathis, Jeffrey J. Pouliot, Pek Yoke Chong
المصدر: Journal of Medicinal Chemistry. 62:3254-3267
مصطلحات موضوعية: Viral protein, Hepatitis C virus, Hepacivirus, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Benzofuran, NS5B, Polymerase, Nucleic Acid Synthesis Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, biology, Boronic Acids, Rats, 0104 chemical sciences, Macaca fascicularis, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, biology.protein, Molecular Medicine, Boronic acid, Half-Life
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2
المؤلفون: Andrew J. Peat, Kurt Weaver, Liping Wang, Sebahar Paul Richard, Eugene L. Stewart, Amanda Mathis, Robert T. Nolte, Dulce Garrido, Robert G. Ferris, Mark P. Edelstein, Huichang Zhang, Pek Yoke Chong, Michael Youngman
المصدر: Journal of Medicinal Chemistry. 55:10601-10609
مصطلحات موضوعية: Models, Molecular, Chemistry, Rational design, Human immunodeficiency virus (HIV), Microbial Sensitivity Tests, Crystallography, X-Ray, medicine.disease_cause, Virology, HIV Reverse Transcriptase, Reverse transcriptase, Biochemistry, Drug Design, Drug Discovery, Hydrolase, HIV-1, medicine, Reverse Transcriptase Inhibitors, Molecular Medicine, Nucleoside
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3
المؤلفون: Subramanian Baskaran, Renae M. Crosby, John W. Seal, Zhiping Z. Xiong, Mi Xie, Hamilton D. Dickson, Roopa Rai, Pek Yoke Chong, Uli Schmitz, Jeffrey J. Pouliot, Derek J. Parks, J. Brad Shotwell, Amanda Mathis, Michael Thomson, Daniel J. Price, Jing Fang, Jack Maung, Katrina L. Creech, Dulce Garrido, Vincent W.-F. Tai, Andrew J. Peat
المصدر: ACS Medicinal Chemistry Letters. 3:565-569
مصطلحات موضوعية: business.industry, viruses, Hepatitis C virus, Organic Chemistry, virus diseases, Hepatitis C, Synergistic combination, Pharmacology, medicine.disease, medicine.disease_cause, Biochemistry, Small molecule, digestive system diseases, In vitro, Drug Discovery, medicine, Replicon, business, IC50, EC50
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4
المؤلفون: John W. Seal, Dan Todd, Banka Anna L, Luz H. Carballo, Zhiping Xiong, Lisa L. Stroup, Amanda Mathis, Zhi Hong, Jeffery J. Pouliot, Pek Yoke Chong, Michael Youngman, Robert Hamatake, Daniel J. Price, Jing Fang, Katrina L. Creech, Andrew Spaltenstein, John G. Catalano, Christopher Don Roberts, J. Brad Shotwell, Andrew J. Peat, Vincent W.-F. Tai, John F. Miller, Sylvia Furst, Huichang Zhang
المصدر: Journal of medicinal chemistry. 57(5)
مصطلحات موضوعية: Ligand efficiency, Chemistry, Viral nonstructural protein, viruses, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Virus Replication, Virology, Small molecule, Antiviral Agents, Hepatitis C, In vitro, Disease Models, Animal, Mice, Viral replication, In vivo, Area Under Curve, Drug Discovery, medicine, Molecular Medicine, Potency, Animals, Prodrugs
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5
المؤلفون: Maosheng Duan, Pat Wheelan, Rena Nishizawa, Pek Yoke Chong, Mark P. Edelstein, Huichang Zhang, Felix Deanda, Rob Ferris, Jennifer Poole Peckham, Zhiping Xiong, Wieslaw M. Kazmierski, Yoshikazu Takaoka
المصدر: Bioorganicmedicinal chemistry letters. 21(21)
مصطلحات موضوعية: Chemokine, biology, Chemistry, Stereochemistry, medicine.drug_class, Anti-HIV Agents, Organic Chemistry, Clinical Biochemistry, Antagonist, Carboxylic Acids, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Amides, Rats, Pharmacokinetics, CCR5 Receptor Antagonists, Drug Discovery, biology.protein, medicine, Molecular Medicine, Animals, Molecular Biology