المؤلفون: Tam HH; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Melo MB; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139., Kang M; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139., Pelet JM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Ruda VM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Foley MH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Hu JK; Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037., Kumari S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139., Crampton J; Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037., Baldeon AD; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Sanders RW; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam-Zuidoost, The Netherlands., Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021., Crotty S; Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037; Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92037., Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139., Anderson DG; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; djirvine@mit.edu dgander@mit.edu arupc@mit.edu., Chakraborty AK; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; djirvine@mit.edu dgander@mit.edu arupc@mit.edu., Irvine DJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, & Harvard, Cambridge, MA 02139; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Howard Hughes Medical Institute, Chevy Chase, MD 20815 djirvine@mit.edu dgander@mit.edu arupc@mit.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Oct 25; Vol. 113 (43), pp. E6639-E6648. Date of Electronic Publication: 2016 Oct 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: AIDS Vaccines/*administration & dosage , Antibodies, Viral/*biosynthesis , B-Lymphocytes/*drug effects , Germinal Center/*drug effects , HIV Envelope Protein gp120/*administration & dosage , Vaccination/*methods, Adjuvants, Immunologic/administration & dosage ; Animals ; Antibody Affinity ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; CHO Cells ; Cricetulus ; Drug Administration Schedule ; Female ; Germinal Center/cytology ; Germinal Center/immunology ; HEK293 Cells ; HIV Envelope Protein gp120/biosynthesis ; Humans ; Immunogenicity, Vaccine ; Infusion Pumps, Implantable ; Lipid A/administration & dosage ; Lipid A/analogs & derivatives ; Mice ; Mice, Inbred C57BL ; Osmotic Pressure ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/biosynthesis ; Vaccination/instrumentation

المؤلفون: Khan OF; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Zaia EW; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Jhunjhunwala S; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Xue W; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ‡Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Cai W; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Yun DS; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Barnes CM; ∥Alnylam Pharmaceuticals, Cambridge, Massachusetts 02142, United States., Dahlman JE; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Dong Y; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; §Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, United States., Pelet JM; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Webber MJ; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Tsosie JK; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Jacks TE; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ‡Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; #Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Langer R; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ∇Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Anderson DG; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ∇Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

المصدر: Nano letters [Nano Lett] 2015 May 13; Vol. 15 (5), pp. 3008-16. Date of Electronic Publication: 2015 Apr 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE

مواضيع طبية MeSH: Gene Transfer Techniques*, Dendrimers/*chemistry , Nanostructures/*chemistry , RNA, Small Interfering/*chemistry, Animals ; Dendrimers/therapeutic use ; Endothelial Cells/drug effects ; Humans ; Lung/drug effects ; Lung/pathology ; Nanostructures/therapeutic use ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use

المؤلفون: Khan OF; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA)., Zaia EW, Yin H, Bogorad RL, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Dec 22; Vol. 53 (52), pp. 14397-401. Date of Electronic Publication: 2014 Oct 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Amines/*chemistry , Dendrimers/*chemistry , RNA, Small Interfering/*metabolism, Cell Line, Tumor ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Factor VII/antagonists & inhibitors ; Factor VII/genetics ; Factor VII/metabolism ; HeLa Cells ; Humans ; Liver/cytology ; Nanostructures/chemistry ; RNA Interference ; Transfection ; alpha-Fetoproteins/antagonists & inhibitors ; alpha-Fetoproteins/genetics ; alpha-Fetoproteins/metabolism

المؤلفون: Dong Y; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA, 02115, USA., Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG

المصدر: Advanced healthcare materials [Adv Healthc Mater] 2014 Sep; Vol. 3 (9), pp. 1392-7. Date of Electronic Publication: 2014 Mar 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression* , Gene Silencing*, Lipids/*chemistry , Nanostructures/*chemistry , Transfection/*methods, Animals ; HeLa Cells ; Humans ; Lipids/pharmacokinetics ; Mice ; Mice, Inbred C57BL ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Triazines/chemistry

المؤلفون: Eltoukhy AA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Chen D; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Veiseh O; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Pelet JM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Yin H; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Dong Y; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States., Anderson DG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: dgander@mit.edu.

المصدر: Biomaterials [Biomaterials] 2014 Aug; Vol. 35 (24), pp. 6454-61. Date of Electronic Publication: 2014 May 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

مواضيع طبية MeSH: Drug Delivery Systems*, Avidin/*metabolism , Horseradish Peroxidase/*metabolism , Intracellular Space/*metabolism , Lipids/*chemistry , Nanoparticles/*chemistry , Nucleic Acids/*metabolism, Animals ; Biophysical Phenomena ; Carbocyanines/metabolism ; DNA/metabolism ; Electrophoresis, Polyacrylamide Gel ; Female ; HeLa Cells ; Humans ; Immunohistochemistry ; Mice, Inbred C57BL ; Oligonucleotides/metabolism ; Spectroscopy, Near-Infrared ; Spleen/metabolism

المؤلفون: Karagiannis ED; David H. Koch Institute for Integrative Cancer Research, ‡Department of Chemical Engineering, and §Division of Health Science and Technology, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02142, United States., Urbanska AM, Sahay G, Pelet JM, Jhunjhunwala S, Langer R, Anderson DG

المصدر: ACS nano [ACS Nano] 2013 Oct 22; Vol. 7 (10), pp. 8616-26. Date of Electronic Publication: 2013 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

مواضيع طبية MeSH: Biomimetics* , Peptide Library*, Peptides/*pharmacokinetics, Amino Acid Sequence ; Drug Design ; Endocytosis ; Humans ; Molecular Sequence Data ; Peptides/chemistry ; Pinocytosis ; Tissue Distribution

المؤلفون: Zhang Y; David H. Koch Institute for Integrative, Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA., Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG

المصدر: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2013 Sep 06; Vol. 25 (33), pp. 4641-5. Date of Electronic Publication: 2013 Jun 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE

مواضيع طبية MeSH: Gene Transfer Techniques*, Aminoglycosides/*chemistry , Lipids/*chemistry , RNA, Small Interfering/*metabolism, Animals ; HeLa Cells ; Humans ; Mice ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/genetics

المؤلفون: Heller DA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Levi Y, Pelet JM, Doloff JC, Wallas J, Pratt GW, Jiang S, Sahay G, Schroeder A, Schroeder JE, Chyan Y, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG

المصدر: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2013 Mar 13; Vol. 25 (10), pp. 1449-54. Date of Electronic Publication: 2012 Dec 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: PubMed not MEDLINE

المؤلفون: Pelet JM; School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA., Putnam D

المصدر: Pharmaceutical research [Pharm Res] 2013 Feb; Vol. 30 (2), pp. 362-76. Date of Electronic Publication: 2012 Sep 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: Transfection*, Acrylic Resins/*chemistry , Agmatine/*chemistry , Drug Carriers/*chemistry , Galactosamine/*chemistry , RNA, Small Interfering/*administration & dosage, Acrylic Resins/metabolism ; Agmatine/metabolism ; Agmatine/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Combinatorial Chemistry Techniques ; Drug Carriers/metabolism ; Drug Carriers/toxicity ; Galactosamine/metabolism ; Galactosamine/toxicity ; Gene Expression ; Heparin/metabolism ; Humans ; Luciferases/genetics ; Particle Size ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Serum/metabolism

المؤلفون: Pelet JM; Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA. dap43@cornell.edu, Putnam D

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2011 Mar 16; Vol. 22 (3), pp. 329-37. Date of Electronic Publication: 2011 Feb 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Acrylic Resins/*chemistry , Morpholines/*chemistry , Polymethacrylic Acids/*chemistry, Agmatine/chemistry ; Galactosamine/chemistry ; Hydrogen-Ion Concentration ; Ligands ; Magnetic Resonance Spectroscopy ; Structure-Activity Relationship