المؤلفون: Inês Loureiro, Jane MacDougall, Isbaal. Ramos, Paul Kong Thoo-Lin, Meritxell Roura, Anabela Cordeiro-da-Silva, Alain Pruvost, Joana Tavares, David Costa, Hadjer Loukil, Nuno A. G. Graça, Luís Gaspar, Ian K. Pemberton

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Pentamidine/pharmacology, Naphthalimides/pharmacology, Neurons/metabolism, Mitochondria, Liver, Microsomes, Liver/metabolism, Pharmacology, Parasite load, Parasite Load, Neurons/cytology, Mice, 0302 clinical medicine, Macrophages/drug effects, Drug Stability, Trypanocidal Agents/chemical synthesis, Liver/drug effects, Trypanosoma brucei brucei/drug effects, Pharmacology (medical), African trypanosomiasis, Trypanosoma brucei brucei/metabolism, Hepatocytes/cytology, Neurons, Mice, Inbred BALB C, biology, Trypanosoma brucei brucei/growth & development, Trypanocidal Agents, 3. Good health, Naphthalimides, Infectious Diseases, Liver, Microsomes, Liver, Female, Trypanosomiasis, African/parasitology, Hepatocytes/drug effects, medicine.drug, Liver/metabolism, 030231 tropical medicine, Trypanosoma brucei brucei, Primary Cell Culture, Mitochondria, Liver/metabolism, Trypanosoma brucei, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Inhibitory Concentration 50, Macrophages/metabolism, medicine, Mitochondria, Liver/drug effects, Structure–activity relationship, Animals, Humans, Experimental Therapeutics, Pentamidine, Trypanocidal agent, Naphthalimides/chemical synthesis, Trypanosomiasis, African/mortality, business.industry, Macrophages, Hepatocytes/metabolism, Macrophages/cytology, medicine.disease, biology.organism_classification, Neurons/drug effects, Survival Analysis, 030104 developmental biology, Trypanosomiasis, African, Cell culture, Trypanosomiasis, African/pathology, Immunology, Hepatocytes, Trypanosomiasis, African/drug therapy, Microsomes, Liver/drug effects, business, Trypanosomiasis, Trypanocidal Agents/pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa525ec4ee871c187c8e2ab92ea4a7
https://repositorio-aberto.up.pt/handle/10216/118203

المؤلفون: Dominique Sainte-Marie, Nicolas Fasel, Pierre Couppié, Ricardo Martin, Frédéric Schütz, Florence Robert-Gangneux, Antoine Bertolotti, Catherine Ronet, Mary-Anne Hartley, Marine Ginouves, Ghislaine Prévot, Francine Pratlong, J. Dufour, Eliane Bourreau, Jean-Pierre Gangneux

المساهمون: Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Université de Lausanne = University of Lausanne (UNIL), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Parasitologie-Mycologie [Rennes], Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de Dermatologie et Vénérologie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de Référence des Leishmanioses [CHRU Montpellier] (CNR-L), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Swiss Institute of Bioinformatics [Lausanne] (SIB), OPP1056785, Bill and Melinda Gates Foundation (Grand Challenges Explorations, Pierre Mercier Foundation (to C. R.), the Guiana Pasteur Institute–, 3100A0-116665/1, the French Ministry for Higher Education and Research, We thank Stephen Beverley (Washington University, St Louis, Missouri) and Jean-Claude Dujardin (Institute of Tropical Medecine, Antwerp, Belgium), for discussions and communications of unpublished data, the Pôle Intégré de Recherche Clinique of the Pasteur Institute, notably Nathalie Jolly, who facilitated the ethical approval, and Prof Pascal Launois, for helpful discussion, and Stéphane Simon, Loic Taglignani, and Patrick Lami, for their contribution regarding the Leishmania parasite cultures., Université de Lausanne (UNIL), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Montpellier (UM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

المصدر: Journal of Infectious Diseases
Journal of Infectious Diseases, 2016, 213 (1), pp.105-111. ⟨10.1093/infdis/jiv355⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2016, 213 (1), pp.105-111. ⟨10.1093/infdis/jiv355⟩

مصطلحات موضوعية: Leishmaniasis, Mucocutaneous, Male, 0301 basic medicine, MESH: Leishmaniasis, Mucocutaneous/virology, MESH: Treatment Failure, MESH: Antiprotozoal Agents/therapeutic use, [SDV]Life Sciences [q-bio], Cohort Studies, MESH: Leishmania guyanensis/virology, Recurrence, mutualism exclusive, guyanensis, MESH: Leishmaniasis, Mucocutaneous/epidemiology, MESH: Leishmaniavirus, MESH: Leishmania guyanensis/drug effects, Immunology and Allergy, MESH: Antiprotozoal Agents/pharmacology, Treatment Failure, Leishmaniavirus, Leishmania RNA virus, Leishmania guyanensis, MESH: Cohort Studies, MESH: Leishmaniasis, Mucocutaneous/drug therapy, drug treatment, 3. Good health, Infectious Diseases, Cohort, Female, medicine.drug, Adult, Antiprotozoal Agents, Biology, 03 medical and health sciences, Cutaneous leishmaniasis, pentamidine, medicine, Humans, MESH: Pentamidine/pharmacology, MESH: Humans, leishmaniasis L, RNA virus, Leishmaniasis, MESH: Adult, medicine.disease, Leishmania, biology.organism_classification, MESH: Male, MESH: Recurrence, 030104 developmental biology, Immunology, MESH: Pentamidine/therapeutic use, MESH: Female, Pentamidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb972dea50a3b696f8fe15a792e41637
https://univ-rennes.hal.science/hal-01175528

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