لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Leiria, LOS, Mónica, FZT, Carvalho, FDGF, Claudino, MA, Franco-Penteado, CF, Schenka, A, Grant, AD, De Nucci, G, Antunes, E, Leiria, L O S, Mónica, F Z T, Carvalho, F D G F, Claudino, M A, Franco-Penteado, C F, Grant, A D

المصدر: British Journal of Pharmacology; Jul2011, Vol. 163 Issue 6, p1276-1288, 13p

مصطلحات موضوعية: BLADDER diseases, STREPTOZOTOCIN, CALCIUM channels, DIABETES, GENE expression, CYSTOMETRY, LABORATORY mice, CALCIUM metabolism, DIABETES complications, RNA metabolism, CALCIUM antagonists, AMIDES, ANIMAL experimentation, CALCIUM chloride, CELL receptors, COMPARATIVE studies, ENZYME inhibitors, GENES, RESEARCH methodology, MEDICAL cooperation, MICE, NIFEDIPINE, PARASYMPATHOMIMETIC agents, PHOSPHOTRANSFERASES, PYRIDINE, RESEARCH, RESEARCH funding, RNA, EVALUATION research, PHARMACODYNAMICS

المؤلفون: Brito PL; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Dos Santos AF; Centro de Hematologia e Hemoterapia do Paraná, Curitiba, Paraná, Brazil., Chweih H; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Favero ME; University Hospital, State University of Londrina, Londrina, Brazil., Gotardo EMF; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Silva JAF; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Leonardo FC; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Franco-Penteado CF; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., de Oliveira MG; Department of Pharmacology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Ferreira WA Jr; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Zaidan BC; Department of Pathology, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Billis A; Department of Pathology, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Baldanzi G; Centro de Hematologia e Hemoterapia do Paraná, Curitiba, Paraná, Brazil., Mashima DA; University Hospital, State University of Londrina, Londrina, Brazil., Antunes E; Department of Pharmacology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Saad STO; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Costa FF; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil., Conran N; Hematology and Transfusion Center, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

المصدر: PloS one [PLoS One] 2022 Feb 03; Vol. 17 (2), pp. e0263424. Date of Electronic Publication: 2022 Feb 03 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Anemia, Sickle Cell/*drug therapy , Anemia, Sickle Cell/*physiopathology , Angiotensin-Converting Enzyme Inhibitors/*pharmacology , Blood Pressure/*drug effects , Peptidyl-Dipeptidase A/*biosynthesis, Adolescent ; Adult ; Angiotensin II/metabolism ; Animals ; Diastole ; Disease Models, Animal ; Female ; Humans ; Hydroxyurea/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Real-Time Polymerase Chain Reaction ; Renin/blood ; Renin-Angiotensin System ; Systole ; Young Adult

المؤلفون: Zapponi KCS; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil., Orsi FA; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil. fernanda.orsi@uol.com.br.; Leiden University Medical Center (LUMC), Leiden, The Netherlands. fernanda.orsi@uol.com.br., Cunha JLR; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil., de Brito IR; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Romano AVC; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil., Bittar LF; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil.; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil., De Paula EV; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil., Penteado CF; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil., Montalvão S; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil., Annichino-Bizzacchi JM; Hematology and Hemotherapy Center, University of Campinas, Carlos Chagas street, 480, Campinas, 13083-878, Brazil.

المصدر: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2022 Jan; Vol. 53 (1), pp. 30-42. Date of Electronic Publication: 2021 Aug 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE

مواضيع طبية MeSH: Extracellular Traps*/metabolism , Venous Thromboembolism*, Endothelial Cells/metabolism ; Humans ; Neutrophil Activation ; Neutrophils/metabolism

المؤلفون: Ferreira WA Jr; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Chweih H; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Lanaro C; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Almeida CB; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Brito PL; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Gotardo EMF; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Torres L; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Miguel LI; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Franco-Penteado CF; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Leonardo FC; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Garcia F; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Saad STO; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Frenette PS; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Brockschnieder D; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Costa FF; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Stasch JP; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Sandner P; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.)., Conran N; Hematology Center, School of Medical Sciences, University of Campinas (UNICAMP), Brazil (W.A.F., H.C., C.L., C.B.A., P.L.B., E.M.F.G., L.T., L.I.M., C.F.F.-P., F.C.L., F.G., S.S.T.O., F.F.C., N.C.); Bayer AG, Pharmaceuticals - Drug Discovery, Wuppertal, Germany (D.B., J.P.S., P.S.); Ruth L. and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York (P.S.F.); and Hannover Medical School, Institute of Pharmacology, Hannover, Germany (P.S.) conran@unicamp.br.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Sep; Vol. 374 (3), pp. 469-478. Date of Electronic Publication: 2020 Jul 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Anemia, Sickle Cell/*drug therapy , Anemia, Sickle Cell/*metabolism , Hydroxyurea/*pharmacokinetics , Soluble Guanylyl Cyclase/*metabolism, Animals ; Benzoates/pharmacology ; Biphenyl Compounds/pharmacology ; Cell Line, Tumor ; Disease Models, Animal ; Erythroid Cells/drug effects ; Erythroid Cells/metabolism ; Fetal Hemoglobin/metabolism ; Humans ; Hydrocarbons, Fluorinated/pharmacology ; K562 Cells ; Male ; Mice ; Mice, Inbred C57BL ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Vascular Diseases/drug therapy ; Vascular Diseases/metabolism ; Vasodilator Agents/pharmacology